{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:37:32Z","timestamp":1793176652077,"version":"4.5.0"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"42","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"State Key Laboratory of Chemo and Biosensing, Hunan University"},{"name":"National Natural Science Foundation of China (NSFC)","award":["22074069"],"award-info":[{"award-number":["22074069"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22474065"],"award-info":[{"award-number":["22474065"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Photothermal therapy has attracted extensive attention in tumor treatment owing to its spatiotemporal controllability and noninvasiveness. However, the nonselective \u201calways on\u201d nature of traditional photothermal nanoagents together with the intrinsic thermal resistance within tumor cells has hampered the therapeutic efficacy. Herein, we developed a tumor-microenvironment-responsive transformable prenanotherapeutic platform with a polyethyleneimine (PEI)-coated tannic acid-Ca2+ chelate core and an outer shell of Fe2+-doped ZIF-90, which enabled the in situ generation of photothermal agents, synchronous activation of multiple therapeutic modalities, as well as cascaded synergistic enhancement of antitumor potency. First, degradation triggered by high-concentration adenosine triphosphate (ATP) and mild acidity within tumor cells liberated Fe2+ to catalyze hydroxyl radical (\u00b7OH) production for chemodynamic therapy. Meanwhile, the generated Fe3+ readily underwent in situ self-assembly with tannic acid to form photothermal agents, which competitively released Ca2+ and induced calcium overload. Subsequently, the dual mitochondrial destruction pathway induced by \u00b7OH and excess Ca2+ suppressed ATP synthesis, which further downregulated the expression of heat shock protein 70 and elevated tumor cell thermosensitivity to realize mild photothermal therapy. Moreover, heat generated via photothermal agents enhanced the efficiency of Fenton-like reactions for robust \u00b7OH accumulation, further improving the therapeutic efficacy. In vitro experiments revealed the underlying synergistic antitumor mechanism, while in vivo experiments confirmed the remarkable tumor suppression capacity of the nanomaterial. Notably, an intelligent TME-responsive \u201cOFF-to-ON\u201d multifunctional nanoplatform was fabricated on the basis of differential binding affinities of metal ions and polyphenols, offering a safer, more efficient and precise strategy for synergistic cancer therapy.<\/jats:p>","DOI":"10.1021\/acsami.6c17046","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:02:10Z","timestamp":1792429330000},"page":"57312-57329","source":"Crossref","is-referenced-by-count":0,"title":["Dual-Responsive Nanoplatform: In Situ Self-Assembly Enables OFF-to-ON Photothermal Switching for Multimodal Synergistic Tumor Therapy"],"prefix":"10.1021","volume":"18","author":[{"given":"Fang-Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yue","family":"Tian","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Wen","family":"He","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-9007","authenticated-orcid":true,"given":"Wen-You","family":"Li","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Kui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300071"]},{"name":"Chinese Academy of Sciences , , ,","place":["Dalian, China, 116023"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"issue":"(2)","key":"2026102802073999400_cit1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41571-023-00846-y","article-title":"Myeloid-derived suppressor cells in cancer and cancer therapy","volume":"21","author":"Lasser","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"2026102802073999400_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101626","article-title":"For and against tumor microenvironment: Nanoparticle-based strategies for active cancer therapy","volume":"31","author":"Karimi","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"(1)","key":"2026102802073999400_cit3","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1186\/s12943-025-02506-4","article-title":"Pyroptosis in cancer therapy: a double-edged sword for immune activation and tumor progression","volume":"24","author":"Alishvandi","year":"2025","journal-title":"Mol. Cancer"},{"issue":"(10)","key":"2026102802073999400_cit4","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202514605","article-title":"Friends fight the foes: synergistic low-temperature photothermal\/chemo\/gas therapy for conquering cancer cells","volume":"36","author":"Li","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"(9)","key":"2026102802073999400_cit5","doi-asserted-by":"publisher","first-page":"7979","DOI":"10.1021\/acsnano.3c00891","article-title":"Photodynamic and photothermal therapies: synergy opportunities for nanomedicine","volume":"17","author":"Overchuk","year":"2023","journal-title":"ACS Nano"},{"issue":"(3)","key":"2026102802073999400_cit6","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10639","article-title":"Photothermal Prussian blue nanoparticles generate potent multi-targeted tumor-specific T cells as an adoptive cell therapy","volume":"9","author":"Sweeney","year":"2023","journal-title":"Bioeng. Transl. Med."},{"key":"2026102802073999400_cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.145677","article-title":"Mild photothermal treatment sensitized immune checkpoint blockade therapy based on ATP-exhausted nanoenzymes","volume":"474","author":"Zhang","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"(7)","key":"2026102802073999400_cit8","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409157","article-title":"Recent advances in strategies to enhance photodynamic and photothermal therapy performance of single-component organic phototherapeutic agents","volume":"12","author":"Fang","year":"2025","journal-title":"Adv. Sci."},{"issue":"(3)","key":"2026102802073999400_cit9","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-010272","article-title":"Thermoresistant flagellin-adjuvanted cancer vaccine combined with photothermal therapy synergizes with anti-PD-1 treatment","volume":"13","author":"Thiruppathi","year":"2025","journal-title":"J. Immunother. Cancer"},{"issue":"(1)","key":"2026102802073999400_cit10","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1186\/s12951-023-02111-x","article-title":"Near-infrared photodynamic and photothermal co-therapy based on organic small molecular dyes","volume":"21","author":"Guo","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"(5)","key":"2026102802073999400_cit11","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051374","article-title":"Near-infrared fluorescent hydroxyapatite nanoparticles for targeted photothermal cancer therapy","volume":"15","author":"Jo","year":"2023","journal-title":"Pharmaceutics"},{"issue":"(2)","key":"2026102802073999400_cit12","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202414879","article-title":"Facile synthesis of Fe-based metal-quinone networks for mutually enhanced mild photothermal therapy and ferroptosis","volume":"64","author":"Liu","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"issue":"(17)","key":"2026102802073999400_cit13","doi-asserted-by":"publisher","first-page":"6461","DOI":"10.1039\/D1QM00630D","article-title":"HSPA1A-siRNA nucleated gold nanorods for stimulated photothermal therapy through strategic heat shock to HSP70","volume":"5","author":"Kim","year":"2021","journal-title":"Mater. Chem. Front."},{"issue":"(18)","key":"2026102802073999400_cit14","doi-asserted-by":"publisher","first-page":"21965","DOI":"10.1021\/acsami.3c02964","article-title":"Revealing the effect of photothermal therapy on human breast cancer cells: A combined study from mechanical properties to membrane HSP70","volume":"15","author":"Guo","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026102802073999400_cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.136169","article-title":"Three-staged tumor inhibition by mitochondria-targeted cascaded gas\/mild-photothermal\/photodynamic synergistic therapy","volume":"442","author":"Luo","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"(33)","key":"2026102802073999400_cit16","doi-asserted-by":"publisher","first-page":"43302","DOI":"10.1021\/acsami.4c08129","article-title":"MXene-polydopamine-antiCEACAM1 antibody complex as a strategy for targeted ablation of melanoma","volume":"16","author":"Konieva","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"(39)","key":"2026102802073999400_cit17","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201904144","article-title":"Size switchable nanoclusters fueled by extracellular ATP for promoting deep penetration and MRI-guided tumor photothermal therapy","volume":"29","author":"Zhou","year":"2019","journal-title":"Adv. Funct. Mater."},{"issue":"(6)","key":"2026102802073999400_cit18","doi-asserted-by":"publisher","first-page":"6879","DOI":"10.1021\/acsnano.9b01665","article-title":"Cancer-cell-activated photodynamic therapy assisted by Cu(II)-based metal-organic framework","volume":"13","author":"Wang","year":"2019","journal-title":"ACS Nano"},{"issue":"(28)","key":"2026102802073999400_cit19","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202512555","article-title":"Tumor microenvironment activated heptamethine cyanine photosensitizer for in situ CuS nanoparticle generation triggering near infrared fluorescence imaging and synergistic photothermal\/photodynamic therapy","volume":"22","author":"An","year":"2026","journal-title":"Small"},{"issue":"(15)","key":"2026102802073999400_cit20","doi-asserted-by":"publisher","first-page":"6987","DOI":"10.7150\/thno.44569","article-title":"TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy","volume":"10","author":"Luo","year":"2020","journal-title":"Theranostics"},{"issue":"(26)","key":"2026102802073999400_cit21","doi-asserted-by":"publisher","first-page":"4749","DOI":"10.1002\/adfm.201600031","article-title":"Thermoresponsive nanogel-encapsulated PEDOT and HSP70 inhibitor for improving the depth of the photothermal therapeutic effect","volume":"26","author":"Liu","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"2026102802073999400_cit22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-025-60343-x","article-title":"Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain","volume":"16","author":"Mas","year":"2025","journal-title":"Nat. Commun."},{"key":"2026102802073999400_cit23","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.actbio.2025.03.048","article-title":"Polypeptide nanoparticles obstruct glucose supply for NIR-II fluorescence-guided tumor starvation and enhanced mild photothermal therapy","volume":"198","author":"Wang","year":"2025","journal-title":"Acta Biomater."},{"key":"2026102802073999400_cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2026.115950","article-title":"A synergistic nanoplatform integrating phototherapy-triggered immunogenic cell death and PKM2-targeted gene therapy for durable tumor control","volume":"267","author":"Sun","year":"2026","journal-title":"Colloids Surf., B"},{"key":"2026102802073999400_cit25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-025-03379-x","article-title":"Visualization of HSP70-regulated mild-photothermal therapy for synergistic tumor treatment: a precise space-time mild-temperature photothermal ablation strategy","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"(24)","key":"2026102802073999400_cit26","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202102595","article-title":"Dual-depletion of intratumoral lactate and ATP with radicals generation for cascade metabolic-chemodynamic therapy","volume":"8","author":"Tian","year":"2021","journal-title":"Adv. Sci."},{"issue":"1","key":"2026102802073999400_cit27","doi-asserted-by":"publisher","DOI":"10.3390\/nano14010112","article-title":"Functionalized nanomaterials for inhibiting ATP-dependent heat shock proteins in cancer photothermal\/photodynamic therapy and combination therapy","volume":"14","author":"Premji","year":"2024","journal-title":"Nanomaterials"},{"issue":"(1)","key":"2026102802073999400_cit28","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12951-023-01818-1","article-title":"Enhanced mild-temperature photothermal therapy by pyroptosis-boosted ATP deprivation with biodegradable nanoformulation","volume":"21","author":"Liu","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"2026102802073999400_cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2025.137366","article-title":"Tumor hypoxia reversal and ATP inhibition through Zn2+ -overload and enzyme catalysis for enhancing photothermal\/photodynamic synergy therapy","volume":"724","author":"Yao","year":"2025","journal-title":"Colloids Surf. A: Physicochem. Eng. Asp."},{"issue":"(50)","key":"2026102802073999400_cit30","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202106106","article-title":"A robust ROS generation strategy for enhanced chemodynamic\/photodynamic therapy via H2O2\/O2 self-supply and Ca2+ overloading","volume":"31","author":"Shen","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"2026102802073999400_cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114096","article-title":"Polymerized apoferritin: A promising carrier for efficient compartmentalized and deep-layer delivery of calcium donors in tumor Ca overload therapy","volume":"386","author":"Sun","year":"2025","journal-title":"J. Control. Release"},{"key":"2026102802073999400_cit32","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/smll.202206174","article-title":"NIR activated multimodal therapeutics based on metal-phenolic networks-functionalized nanoplatform for combating against multidrug resistance and metastasis","volume":"19","author":"Cheng","year":"2023","journal-title":"Small"},{"issue":"(1)","key":"2026102802073999400_cit33","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1021\/acsnano.1c07893","article-title":"One-step integration of tumor microenvironment-responsive calcium and copper peroxides nanocomposite for enhanced chemodynamic\/ion-interference therapy","volume":"16","author":"Liu","year":"2021","journal-title":"ACS Nano"},{"key":"2026102802073999400_cit34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/anie.202317578","article-title":"Photo-Controlled Calcium Overload from Endogenous Sources for Tumor Therapy","volume":"63","author":"Hu","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026102802073999400_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.153368","article-title":"Harnessing bimetallic iMWA nanosensitizer to unleash ferroptosis and calcium overload: Unlocking tumor vulnerability for potentiated iMWA therapy against hepatocellular carcinoma","volume":"495","author":"Qiu","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"(52)","key":"2026102802073999400_cit36","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202407221","article-title":"Tannic acid selective modulation defects to enhance the photocatalytic CO2 reduction activity of layered double hydroxides","volume":"20","author":"Cui","year":"2024","journal-title":"Small"},{"issue":"(2)","key":"2026102802073999400_cit37","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17020194","article-title":"Modulating polyphenol activity with metal ions: insights into dermatological applications","volume":"17","author":"Cioanca","year":"2025","journal-title":"Pharmaceutics"},{"key":"2026102802073999400_cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122284","article-title":"Synergistic ROS generation and directional overloading of endogenous calcium induce mitochondrial dysfunction in living cells","volume":"301","author":"Shao","year":"2023","journal-title":"Biomaterials"},{"key":"2026102802073999400_cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2026.103354","article-title":"MOF composites for hyperthermia applications","volume":"97","author":"Panaite","year":"2026","journal-title":"Mater. Today"},{"issue":"(5)","key":"2026102802073999400_cit40","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1021\/acs.molpharmaceut.4c01474","article-title":"Metal-polyphenol self-assembled nanophotothermal agent for precise mitochondrial targeted photothermal therapy","volume":"22","author":"Zhou","year":"2025","journal-title":"Mol. Pharm."},{"key":"2026102802073999400_cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123740","article-title":"Tumor microenvironment-responsive NanoShield for precision photodynamic and photothermal synergistic cancer therapy with mitigated skin phototoxicity","volume":"327","author":"Zhang","year":"2026","journal-title":"Biomaterials"},{"issue":"(13)","key":"2026102802073999400_cit42","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202411242","article-title":"Self-assembly of H2S-generating photosensitizer for gas-assisted synergistic photothermal therapy","volume":"21","author":"Kong","year":"2025","journal-title":"Small"},{"issue":"(6)","key":"2026102802073999400_cit43","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.1039\/D5CS01306B","article-title":"Molecular fluorophore dimerization: a new paradigm for precision phototheranostics","volume":"55","author":"Bian","year":"2026","journal-title":"Chem. Soc. Rev."},{"issue":"(4)","key":"2026102802073999400_cit44","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202521465","article-title":"In situ coordination-assembly nano-drugs\/probes for enhanced tumor retention and responsive release","volume":"65","author":"Liu","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026102802073999400_cit45","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202521864","article-title":"MPI-guided photothermal therapy of prostate cancer using stem cell delivery of magnetotheranostic nanoflowers","author":"Ghaemi","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"(2)","key":"2026102802073999400_cit46","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1039\/D5MH01167A","article-title":"Bimetallic organic cages as precise theranostic nanoplatforms for self-enhanced magnetic resonance imaging and chemodynamic therapy","volume":"13","author":"Deng","year":"2026","journal-title":"Mater. Horiz."},{"key":"2026102802073999400_cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.141313","article-title":"A pH\/ATP-responsive nanomedicine via disrupting multipath homeostasis of ferroptosis for enhanced cancer therapy","volume":"457","author":"Meng","year":"2023","journal-title":"Chem. Eng. J."},{"key":"2026102802073999400_cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.141841","article-title":"Injectable sodium alginate\/4-arm polyethylene glycol-lipoic acid double-network hydrogel loading Ca2+-tannic acid nanocomposite treats periodontitis via anti-bacteria, ROS scavenging and osteogenesis","volume":"307","author":"Ouyang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"(16)","key":"2026102802073999400_cit49","doi-asserted-by":"publisher","first-page":"5877","DOI":"10.1021\/jacs.7b01229","article-title":"Mitochondria targeted nanoscale zeolitic imidazole framework-90 for ATP imaging in live cells","volume":"139","author":"Deng","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"2026102802073999400_cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2022.132286","article-title":"ATP fluorescent nanoprobe based on ZIF-90 and near-infrared dyes for imaging in tumor mice","volume":"369","author":"Hou","year":"2022","journal-title":"Sens. Actuators, B"},{"key":"2026102802073999400_cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.117987","article-title":"Mitochondria-targeted zeolitic imidazole framework-90: Toward sequential detection and bioimaging of ATP and GSH","volume":"290","author":"Zhang","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"(6)","key":"2026102802073999400_cit52","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1021\/acs.biomac.2c00409","article-title":"Multivalent polypeptide and tannic acid cooperatively iron-coordinated nanohybrids for synergistic cancer photothermal ferroptosis therapy","volume":"23","author":"He","year":"2022","journal-title":"Biomacromolecules"},{"key":"2026102802073999400_cit53","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/smll.202100398","article-title":"Tailored engineering of novel xanthonium polymethine dyes for synergetic PDT and PTT triggered by 1064 nm laser toward deep-seated tumors","volume":"17","author":"Bian","year":"2021","journal-title":"Small"},{"issue":"(49)","key":"2026102802073999400_cit54","doi-asserted-by":"publisher","first-page":"22562","DOI":"10.1021\/jacs.2c08602","article-title":"Cardiolipin-targeted NIR-II fluorophore causes \u201cAvalanche Effects\u201d for re-engaging cancer apoptosis and inhibiting metastasis","volume":"144","author":"Bian","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"2026102802073999400_cit55","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/adhm.202300929","article-title":"A dual heat shock protein down-regulation strategy using PDA\/Cu\/ICG\/R controlled by NIR \u201cswitch\u201d enhances mild-photothermal therapy effect","volume":"12","author":"Ding","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"2026102802073999400_cit56","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc4373","article-title":"GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer","volume":"6","author":"Zhou","year":"2020","journal-title":"Sci. Adv."},{"issue":"(16)","key":"2026102802073999400_cit57","doi-asserted-by":"publisher","first-page":"8061","DOI":"10.1039\/D5SC08871B","article-title":"Zero-trigger ultrafast charge-transfer J-aggregates via Se\/\u03c0-directed assembly enable synchronous ROS\/heat amplification for NIR-II photoimmunotherapy","volume":"17","author":"Ma","year":"2026","journal-title":"Chem. Sci."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c17046","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/42\/57312\/68905407\/am-2026-17046c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/42\/57312\/68905407\/am-2026-17046c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:12:19Z","timestamp":1793175139000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/42\/57312\/5453853\/Dual-Responsive-Nanoplatform-In-Situ-Self-Assembly"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":57,"journal-issue":{"issue":"42","published-online":{"date-parts":[[2026,10,19]]},"published-print":{"date-parts":[[2026,10,28]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c17046","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]}}}