{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:40:53Z","timestamp":1792611653358,"version":"4.5.0"},"reference-count":36,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ50559"],"award-info":[{"award-number":["2025JJ50559"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Asia-Pacific Association of Blood Group and Genomics Scientific Research Fund Project","award":["IAABG23SR003"],"award-info":[{"award-number":["IAABG23SR003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pseudomonas aeruginosa wound infections remain difficult to eradicate because biofilm formation and bacterial redox-adaptive defenses weaken antibacterial efficacy and delay tissue repair. In this study, we reported a near-infrared (NIR)-activated reactive oxygen species (ROS)\/ nitric oxide (NO) cascade nanocomposite, UCeSi-L@CA, designed to amplify oxidative\/nitrosative antibacterial stress while promoting infected wound healing. UCeSi-L@CA was constructed from Ce6-loaded mesoporous silica-coated upconversion nanoparticles, with L-arginine conjugated through surface carboxyl groups and cinnamaldehyde loaded into the mesopores. Upon NIR irradiation, upconversion nanoparticles activated Ce6 to generate abundant ROS. Cinnamaldehyde exerted direct antibacterial activity and inhibited glutathione-mediated ROS scavenging, thereby sustaining ROS accumulation and weakening bacterial antioxidant defense. The accumulated ROS further triggered NO production from L-arginine, establishing a ROS\/NO cascade in which ROS and NO cooperatively damaged bacterial membranes, enhanced lipid peroxidation, and induced efficient bacterial killing. Beyond antibacterial activity, NO also contributed to infected tissue repair. In vitro, UCeSi-L@CA + NIR showed excellent killing against planktonic P. aeruginosa, effectively inhibited biofilm formation, eradicated bacteria within established biofilms, and suppressed biofilm regrowth. In the P. aeruginosa-infected wound model, UCeSi-L@CA + NIR markedly reduced local bacterial burden, attenuated infection-associated inflammation, accelerated wound closure, and promoted tissue repair, with favorable biocompatibility in vitro and in vivo. This nanocomposite presents a non-antibiotic nanotherapeutic strategy integrating NIR-triggered ROS generation, cinnamaldehyde-mediated GSH-defense inhibition, and L-arginine-derived NO release for treating refractory biofilm-associated wound infections.<\/jats:p>","DOI":"10.1021\/acsami.6c17153","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:01:55Z","timestamp":1792609315000},"source":"Crossref","is-referenced-by-count":0,"title":["NIR-Activated ROS\/NO Cascade Nanocomposite Rewires Bacterial Redox Defense for Synergistic Eradication of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    Wound Infection"],"prefix":"10.1021","author":[{"given":"Feng-xia","family":"Liu","sequence":"first","affiliation":[{"name":"the third Xiangya Hospital, Central South University , , ,","place":["Changsha, P. R. China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qu","sequence":"additional","affiliation":[{"name":"the third Xiangya Hospital, Central South University , , ,","place":["Changsha, P. R. China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8067-0287","authenticated-orcid":true,"given":"Ting-ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Hunan University , , ,","place":["Changsha, P. R. China, 410082"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-9538","authenticated-orcid":true,"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"the third Xiangya Hospital, Central South University , , ,","place":["Changsha, P. R. China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"issue":"1","key":"2026102115014393100_cit1","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/s41467-024-44968-y","article-title":"Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing","volume":"15","author":"Pranantyo","year":"2024","journal-title":"Nat. Commun."},{"issue":"35","key":"2026102115014393100_cit2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403101","article-title":"Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa-Infected Pneumonia and Wound","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci."},{"issue":"11","key":"2026102115014393100_cit3","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41579-025-01193-8","article-title":"Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility","volume":"23","author":"Letizia","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"2026102115014393100_cit4","doi-asserted-by":"publisher","first-page":"7658","DOI":"10.1038\/s41467-023-43067-8","article-title":"Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. Commun."},{"issue":"10","key":"2026102115014393100_cit5","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.tim.2025.05.004","article-title":"Pseudomonas aeruginosa: persistence beyond antibiotic resistance","volume":"33","author":"La Rosa","year":"2025","journal-title":"Trends Microbiol."},{"issue":"19","key":"2026102115014393100_cit6","doi-asserted-by":"publisher","first-page":"9677","DOI":"10.3390\/ijms26199677","article-title":"Pseudomonas aeruginosa Pathogenicity and Its Interaction with Other Microorganisms During the Skin Wound Healing Process","volume":"26","author":"Yamberla","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026102115014393100_cit7","doi-asserted-by":"publisher","first-page":"7538","DOI":"10.1038\/s41467-024-51933-2","article-title":"A Foundation Model Identifies Broad-Spectrum Antimicrobial Peptides against Drug-Resistant Bacterial Infection","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"issue":"28","key":"2026102115014393100_cit8","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg9116","article-title":"Targeting and arginine-driven synergizing photodynamic therapy with nutritional immunotherapy nanosystems for combating MRSA biofilms","volume":"9","author":"Zhang","year":"2023","journal-title":"Sci. Adv."},{"issue":"1","key":"2026102115014393100_cit9","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41377-023-01149-8","article-title":"Chemiluminescent carbon nanodots for dynamic and guided antibacteria","volume":"12","author":"Han","year":"2023","journal-title":"Light Sci. Appl."},{"key":"2026102115014393100_cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122571","article-title":"Gram-negative bacteria recognition and photodynamic elimination by Zn-DPA based sensitizers","volume":"308","author":"Wang","year":"2024","journal-title":"Biomaterials"},{"issue":"1","key":"2026102115014393100_cit11","doi-asserted-by":"publisher","first-page":"4943","DOI":"10.1038\/s41467-024-49311-z","article-title":"Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers","volume":"15","author":"Zhuang","year":"2024","journal-title":"Nat. Commun."},{"issue":"2","key":"2026102115014393100_cit12","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.1021\/acsnano.4c15730","article-title":"Charge Regulation-Enhanced Type I Photosensitizer-Loaded Hydrogel Dressing for Hypoxic Bacterial Inhibition and Biofilm Elimination","volume":"19","author":"Xiong","year":"2025","journal-title":"ACS Nano"},{"issue":"1","key":"2026102115014393100_cit13","doi-asserted-by":"publisher","first-page":"9422","DOI":"10.1038\/s41467-024-53764-7","article-title":"H2S scavenger as a broad-spectrum strategy to deplete bacteria-derived H2S for antibacterial sensitization","volume":"15","author":"Sun","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"2026102115014393100_cit14","doi-asserted-by":"publisher","first-page":"10508","DOI":"10.1038\/s41467-025-65527-z","article-title":"Tetrazine-enhanced donor-acceptor-donor metal-organic frameworks for photodynamic antibacterial therapy and wound healing","volume":"16","author":"Chen","year":"2025","journal-title":"Nat. Commun."},{"issue":"19","key":"2026102115014393100_cit15","doi-asserted-by":"publisher","first-page":"18979","DOI":"10.1021\/acsnano.3c04564","article-title":"pH-Responsive Upconversion Mesoporous Silica Nanospheres for Combined Multimodal Diagnostic Imaging and Targeted Photodynamic and Photothermal Cancer Therapy","volume":"17","author":"Palanikumar","year":"2023","journal-title":"ACS Nano"},{"issue":"5","key":"2026102115014393100_cit16","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1021\/acsnano.2c10694","article-title":"Multifunctional AIE Nanosphere-Based \"Nanobomb\" for Trimodal Imaging-Guided Photothermal\/Photodynamic\/Pharmacological Therapy of Drug-Resistant Bacterial Infections","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"issue":"5","key":"2026102115014393100_cit17","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1021\/acsnano.3c08054","article-title":"One-Stop Integrated Nanoagent for Bacterial Biofilm Eradication and Wound Disinfection","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"2026102115014393100_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123602","article-title":"A sprayable TQ\/Ce6@SAB\/F-gel for accelerating wound healing via hypoxia-tolerant photodynamic therapy and immune-metabolic pathway","volume":"325","author":"Li","year":"2026","journal-title":"Biomaterials"},{"issue":"33","key":"2026102115014393100_cit19","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202503793","article-title":"Cu7S4 Nanozyme Efficiently Inactivating Drug-Resistant Bacteria on Mouse Wound Models through Photodynamic and Photothermal Synergetic Therapy","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci."},{"key":"2026102115014393100_cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.142311","article-title":"ROS-Responsive and Self-Amplifying polymeric prodrug for accelerating infected wound healing","volume":"463","author":"Lu","year":"2023","journal-title":"Chem. Eng. J."},{"key":"2026102115014393100_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.153513","article-title":"Heparin mimicking sulfonated polyester synergistically promotes bacterial Infected-Wound healing with ROS responsive cinnamaldehyde based prodrugs","volume":"495","author":"Liu","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"2","key":"2026102115014393100_cit22","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1089\/fpd.2022.0073","article-title":"Inhibitory Effects of Trans-Cinnamaldehyde Against Biofilm Formation","volume":"20","author":"Song","year":"2023","journal-title":"Foodborne Pathog. Dis."},{"issue":"1","key":"2026102115014393100_cit23","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01699-24","article-title":"Role of the two-component system AmgRS in early resistance of to cinnamaldehyde","volume":"13","author":"Dubois","year":"2025","journal-title":"Microbiol. Spectr."},{"issue":"1","key":"2026102115014393100_cit24","doi-asserted-by":"publisher","first-page":"8058","DOI":"10.1038\/s41467-024-52489-x","article-title":"Biodegradable oxygen-evolving metalloantibiotics for spatiotemporal sono-metalloimmunotherapy against orthopaedic biofilm infections","volume":"15","author":"Su","year":"2024","journal-title":"Nat. Commun."},{"issue":"30","key":"2026102115014393100_cit25","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303259","article-title":"Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications","volume":"10","author":"Andrabi","year":"2023","journal-title":"Adv. Sci."},{"issue":"10","key":"2026102115014393100_cit26","doi-asserted-by":"publisher","first-page":"8935","DOI":"10.1021\/acsnano.3c02303","article-title":"Advanced Nitric Oxide Generating Nanomedicine for Therapeutic Applications","volume":"17","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"issue":"1","key":"2026102115014393100_cit27","doi-asserted-by":"publisher","first-page":"7510","DOI":"10.1038\/s41467-023-43415-8","article-title":"Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections","volume":"14","author":"Cheng","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"2026102115014393100_cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwae044","article-title":"Bacteria-responsive programmed self-activating antibacterial hydrogel to remodel regeneration microenvironment for infected wound healing","volume":"11","author":"Yang","year":"2024","journal-title":"Natl. Sci. Rev."},{"issue":"1","key":"2026102115014393100_cit29","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1038\/s41467-026-69624-5","article-title":"Drug-caged drugs enable photocatalytic dual decaging of nitric oxide and anesthetics for antibacterial analgesia","volume":"17","author":"Zhang","year":"2026","journal-title":"Nat. Commun."},{"issue":"2","key":"2026102115014393100_cit30","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s42765-023-00369-2","article-title":"Low-Temperature Trigger Nitric Oxide Nanogenerators for Anti-biofilm and Wound Healing","volume":"6","author":"Su","year":"2024","journal-title":"Adv. Fiber Mater."},{"key":"2026102115014393100_cit31","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.bioactmat.2024.12.012","article-title":"Dual-layer microneedles with NO\/O2 releasing for diabetic wound healing via neurogenesis, angiogenesis, and immune modulation","volume":"46","author":"Liu","year":"2025","journal-title":"Bioact. Mater."},{"issue":"5","key":"2026102115014393100_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202413108","article-title":"Multifunctional Microneedle Patches Loaded With Engineered Nitric Oxide-Releasing Nanocarriers for Targeted and Synergistic Chronic Wound Therapy","volume":"37","author":"Jin","year":"2025","journal-title":"Adv. Mater."},{"issue":"45","key":"2026102115014393100_cit33","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202503992","article-title":"Janus Fibrous Dressing with Controllable Nitric Oxide-Releasing and Unidirectional Exudate Transport Activities for Bacteria-Infected Burn Wound Therapy","volume":"35","author":"Wang","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"2026102115014393100_cit34","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/s41467-024-45072-x","article-title":"In-situ-sprayed therapeutic hydrogel for oxygen-actuated Janus regulation of postsurgical tumor recurrence\/metastasis and wound healing","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"2026102115014393100_cit35","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.bioactmat.2025.06.004","article-title":"Multifunctional DNA hydrogels with light-triggered gas-therapy and controlled G-Exos release for infected wound healing","volume":"52","author":"Ye","year":"2025","journal-title":"Bioact. Mater."},{"issue":"47","key":"2026102115014393100_cit36","doi-asserted-by":"publisher","first-page":"32650","DOI":"10.1021\/acsnano.4c10118","article-title":"Peroxynitrite-Free Nitric Oxide-Embedded Nanoparticles Maintain Nitric Oxide Homeostasis for Effective Revascularization of Myocardial Infarcts","volume":"18","author":"Zhang","year":"2024","journal-title":"ACS Nano"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c17153","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/doi\/10.1021\/acsami.6c17153\/68936006\/am-2026-17153t.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/doi\/10.1021\/acsami.6c17153\/68936006\/am-2026-17153t.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:10:10Z","timestamp":1792609810000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/doi\/10.1021\/acsami.6c17153\/5455734\/NIR-Activated-ROS-NO-Cascade-Nanocomposite-Rewires"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":36,"URL":"https:\/\/doi.org\/10.1021\/acsami.6c17153","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]}}}