{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:01:18Z","timestamp":1791378078715,"version":"4.3.2"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH076"],"award-info":[{"award-number":["ZR2022MH076"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infected wounds are trapped in self-perpetuating acidic and hypoxic microenvironments, yet designing intelligent systems that can sense and remodel such niches remains challenging. Here, we report EBP-Fc-COF, a cationically engineered ferrocene covalent organic framework (COF) for microenvironment-adaptive antibacterial therapy. The material is synthesized via a tandem Knoevenagel condensation and a Menshutkin-type reaction, in which the phosphine centers, owing to their higher nucleophilicity and lower electronegativity than the adjacent pyridinic-N sites, undergo chemoselective ethylation with bromoethane, yielding permanent quaternary phosphonium cations exclusively at the P-centers. This site-specific functionalization affords a uniform spherical morphology and a high photothermal conversion efficiency (\u03b7 = 59.23%). The therapeutic mechanism relies on dual spatiotemporal synergy. The cationic framework electrostatically anchors to negatively charged bacterial membranes, providing spatial targeting. Concurrently, the system exhibits pH-switchable enzyme-mimetic activities for temporal adaptation: at acidic infection pH, it predominantly shows peroxidase-like (POD-like) activity, catalyzing H2O2 into \u00b7OH for localized bacterial killing at the anchored interface. At neutral healing pH, it switches to catalase-like (CAT-like) activity, decomposing H2O2 into O2 to relieve hypoxia. Red-light irradiation further boosts the antibacterial performance by orchestrating cationic, photothermal, and enzymatic actions, achieving efficient disruption of bacteria and biofilms. In an infected wound model, the combination of EBP-Fc-COF, H2O2, and laser irradiation achieved \u223c90% wound closure within nine days. Although not used in the in vivo wound healing experiments, this hydrogel composite was incorporated into a polyacrylamide matrix as an independent and preliminary formulation exploration, which serves solely as an initial feasibility assessment for potential future dressing development and are not part of the therapeutic efficacy validation. The optimized formulation (50 \u03bcg\/mL) exhibited a uniform porous architecture, favorable swelling, excellent biocompatibility, high photothermal stability, reversible joint conformability, and maintained structural integrity after 200 bending cycles, providing an initial feasibility assessment for future development. This work establishes a P-centered precision engineering strategy for COF-based smart platforms, providing a paradigm for spatiotemporally synergistic, microenvironment-adaptive wound therapy.<\/jats:p>","DOI":"10.1021\/acsami.6c17648","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:02:10Z","timestamp":1790082130000},"page":"54109-54129","source":"Crossref","is-referenced-by-count":0,"title":["Site-Specific Engineered Cationic Ferrocene COF with pH-Switchable Dual Enzyme Activities for Infected Wound Care"],"prefix":"10.1021","volume":"18","author":[{"given":"Yijun","family":"Liu","sequence":"first","affiliation":[{"name":"Shandong Second Medical University , , , ,","place":["Weifang, Shandong, China, 261053"]},{"name":"Shandong Second Medical University , , , ,","place":["Weifang, Shandong, PR China, 261053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoming","family":"Yu","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University , , , ,","place":["Weifang, Shandong, China, 261053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Yu","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University , , , ,","place":["Weifang, Shandong, China, 261053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Bian","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University , , , ,","place":["Weifang, Shandong, PR China, 261053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelan","family":"Yu","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University , , , ,","place":["Weifang, Shandong, PR China, 261053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Song","sequence":"additional","affiliation":[{"name":"Weifang Yidu Central Hospital , , ,","place":["Weifang, Shandong, P. R. China, 262500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhengda Tianqing Pharmaceutical Group Co., Ltd. , , ,","place":["Lianyungang, Jiangsu, P. R. China, 222000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Chi","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University , , , ,","place":["Weifang, Shandong, China, 261053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghui","family":"Meng","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University , , , ,","place":["Weifang, Shandong, China, 261053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7781-7842","authenticated-orcid":true,"given":"Baolong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University , , , ,","place":["Weifang, Shandong, PR China, 261053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University , , , ,","place":["Weifang, Shandong, PR China, 261053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wu","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University , , , ,","place":["Weifang, Shandong, China, 261053"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"5","key":"2026100708064986500_cit1","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1016\/j.apsb.2023.12.017","article-title":"Metal Natural Product Complex Ru-Procyanidins with Quadruple Enzymatic Activity Combat Infections from Drug-Resistant Bacteria","volume":"14","author":"Shan","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"2026100708064986500_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101602","article-title":"Biofilm Microenvironment-Responsive Nanoparticles for the Treatment of Bacterial Infection","volume":"46","author":"Hu","year":"2022","journal-title":"Nano Today"},{"key":"2026100708064986500_cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2025.109488","article-title":"Emergence of Antibiotic-Resistant Pathogens in Ancient Deep-Sea Sediments Predates Anthropogenic Antibiotic Use","volume":"199","author":"Wu","year":"2025","journal-title":"Environ. Int."},{"key":"2026100708064986500_cit4","doi-asserted-by":"publisher","first-page":"5235","DOI":"10.2147\/IDR.S319780","article-title":"Surgical Antibiotic Prophylaxis in an Era of Antibiotic Resistance: Common Resistant Bacteria and Wider Considerations for Practice","volume":"14","author":"Menz","year":"2021","journal-title":"Infect. Drug Resist."},{"issue":"12","key":"2026100708064986500_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202000398","article-title":"Relief of Biofilm Hypoxia Using an Oxygen Nanocarrier: A New Paradigm for Enhanced Antibiotic Therapy","volume":"7","author":"Hu","year":"2020","journal-title":"Adv. Sci."},{"issue":"29","key":"2026100708064986500_cit6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210766","article-title":"pH-Triggered Size-Transformable and Bioactivity-Switchable Self-Assembling Chimeric Peptide Nanoassemblies for Combating Drug-Resistant Bacteria and Biofilms","volume":"35","author":"Tan","year":"2023","journal-title":"Adv. Mater."},{"issue":"8","key":"2026100708064986500_cit7","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.3390\/ma15082815","article-title":"A pH-Gated Functionalized Hollow Mesoporous Silica Delivery System for Photodynamic Sterilization in Staphylococcus aureus Biofilm","volume":"15","author":"Zhao","year":"2022","journal-title":"Materials"},{"issue":"11","key":"2026100708064986500_cit8","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.3390\/pharmaceutics15112582","article-title":"Nanotechnology-Based Drug Delivery Systems to Control Bacterial-Biofilm-Associated Lung Infections","volume":"15","author":"Guo","year":"2023","journal-title":"Pharmaceutics"},{"key":"2026100708064986500_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2025.101532","article-title":"Smart Responsive Materials for Antibacterial Therapy: Progress, Opportunities, and Challenges","volume":"155","author":"Fu","year":"2026","journal-title":"Prog. Mater. Sci."},{"issue":"11","key":"2026100708064986500_cit10","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202405103","article-title":"Research Progress on Antibacterial Applications of Bioactive Materials in Wound Infections: Design, Challenges, and Prospects","volume":"14","author":"Zheng","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"2026100708064986500_cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112292","article-title":"Ciprofloxacin Conjugated Gold Nanorods with pH Induced Surface Charge Transformable Activities to Combat Drug Resistant Bacteria and Their Biofilms","volume":"128","author":"Yin","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"issue":"23","key":"2026100708064986500_cit12","doi-asserted-by":"publisher","first-page":"14145","DOI":"10.1039\/d4nr03798g","article-title":"Rational Control of Combined Photothermal and Photodynamic Therapy for Effective Eradication of Biofilms","volume":"17","author":"Ko\u00e7","year":"2025","journal-title":"Nanoscale"},{"issue":"47","key":"2026100708064986500_cit13","doi-asserted-by":"publisher","first-page":"25705","DOI":"10.1021\/jacs.3c09058","article-title":"Adding Flying Wings: Butterfly-Shaped NIR-II AIEgens with Multiple Molecular Rotors for Photothermal Combating of Bacterial Biofilms","volume":"145","author":"Yan","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"2026100708064986500_cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2023.109106","article-title":"Defect-Engineered Cu-MoOv-Based Nanozyme with Enhanced POD-Like Activity for High-Efficient Elimination of Drug-Resistant Bacterial Biofilms","volume":"200","author":"Zhang","year":"2023","journal-title":"Biochem. Eng. J."},{"issue":"32","key":"2026100708064986500_cit15","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202207250","article-title":"Nitric-Oxide-Releasing Aza-BODIPY: A New Near-Infrared J-Aggregate with Multiple Antibacterial Modalities","volume":"61","author":"Bao","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"issue":"11","key":"2026100708064986500_cit16","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/nrmicro2383","article-title":"Protein Glycosylation in Bacteria: Sweeter than Ever","volume":"8","author":"Nothaft","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"issue":"5","key":"2026100708064986500_cit17","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.1021\/acsnano.3c11628","article-title":"Symmetrical Localized Built-In Electric Field by Induced Polarization Effect in Ionic Covalent Organic Frameworks for Selective Imaging and Killing Bacteria","volume":"18","author":"Li","year":"2024","journal-title":"ACS Nano"},{"issue":"2","key":"2026100708064986500_cit18","doi-asserted-by":"publisher","DOI":"10.1002\/sstr.202000078","article-title":"Metal\u2013Organic Framework-Based Hybrid Frameworks","volume":"2","author":"Shan","year":"2021","journal-title":"Small Struct."},{"issue":"33","key":"2026100708064986500_cit19","doi-asserted-by":"publisher","first-page":"13722","DOI":"10.1002\/anie.202004796","article-title":"Metal\u2013Covalent Organic Frameworks (MCOFs): A Bridge Between Metal\u2013Organic Frameworks and Covalent Organic Frameworks","volume":"59","author":"Dong","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"2026100708064986500_cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfin.2025.106226","article-title":"Enhanced Antimicrobial Performance of D-A Covalent Organic Framework with Pyridinium and Quaternary Ammonium Groups and ROS Activity","volume":"62","author":"Ma","year":"2025","journal-title":"Surf. Interfaces"},{"key":"2026100708064986500_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2024.113533","article-title":"Multiple Strategy for Antibacterial Effect via Copper Porphyrin Doping Polyphenolic Aldehydes Based Covalent Organic Framework","volume":"12","author":"Zhou","year":"2024","journal-title":"J. Environ. Chem. Eng."},{"issue":"18","key":"2026100708064986500_cit22","doi-asserted-by":"publisher","first-page":"21656","DOI":"10.1021\/acsanm.4c03235","article-title":"Postmethylation of BODIPY-Based Covalent Organic Framework Nanostructures for Improving Photothermal and Photodynamic Bacterial Inactivation","volume":"7","author":"Ma","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"issue":"41","key":"2026100708064986500_cit23","doi-asserted-by":"publisher","first-page":"56786","DOI":"10.1021\/acsami.5c13840","article-title":"Spatial Distortion-Engineered Cationic Ru-Covalent Organic Framework Overcoming Aggregation-Caused Quenching for Synergistic Photodynamic\/Photothermal Anti-Infective Therapy","volume":"17","author":"Wei","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"47","key":"2026100708064986500_cit24","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407133","article-title":"Bacteria-Mediated Tumor-Targeting Delivery of Multienzyme-Mimicking Covalent Organic Frameworks Promoting Pyroptosis for Combinatorial Sono-Catalytic Immunotherapy","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci."},{"issue":"4","key":"2026100708064986500_cit25","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202512417","article-title":"Dual Fe-Active-Site Engineering in MCOF Nanozymes for Synergistic and Broad-Spectrum Antibacterial Therapy","volume":"22","author":"Liu","year":"2025","journal-title":"Small"},{"key":"2026100708064986500_cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2026.112754","article-title":"A Copper-Decorated COF Nanozyme for NIR-Enhanced ROS Generation against MRSA-Infected Wound Healing","author":"Ullah","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"2026100708064986500_cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2026.215042","article-title":"Calcium-Enhanced COF Platforms for Synergistic Photothermal-Antibacterial Therapy: Unlocking Calcium-Mediated Membrane Disruption and Ion Overload for Bacterial and Biofilm Eradication in Wound Care and Infected Nursing","volume":"188","author":"Jiang","year":"2026","journal-title":"Biomater. Adv."},{"issue":"42","key":"2026100708064986500_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202505669","article-title":"A Self-Oxidizing o-Dihydroxybenzene-Based Covalent Organic Framework Hydrogel with Broad-Spectrum Antibacterial Properties for Promoting Diabetic Wound Healing","volume":"35","author":"Xue","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"26","key":"2026100708064986500_cit29","doi-asserted-by":"publisher","first-page":"28952","DOI":"10.1021\/acsami.0c04080","article-title":"Functionalized GO Nanovehicles with Nitric Oxide Release and Photothermal Activity-Based Hydrogels for Bacteria-Infected Wound Healing","volume":"12","author":"Huang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"19","key":"2026100708064986500_cit30","doi-asserted-by":"publisher","first-page":"7466","DOI":"10.1021\/acssuschemeng.3c00438","article-title":"Post-Synthetic Modification of a Fluorescent Covalent Organic Framework as a Multifunctional Sensor for Efficient Detection of 5-Hydroxytryptamine and Its Metabolite and Latent Fingerprint Identification","volume":"11","author":"Quan","year":"2023","journal-title":"ACS Sustainable Chem. Eng."},{"issue":"41","key":"2026100708064986500_cit31","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202513754","article-title":"Covalent Organic Framework Nanohydrogel-Based Oxidase-Mimicking Nanozyme for Photocatalytic Antibacterial Therapy","volume":"64","author":"Tao","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"2026100708064986500_cit32","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jphotobiol.2017.07.013","article-title":"Triazine-Based Covalent Organic Frameworks for Photodynamic Inactivation of Bacteria as Type-II Photosensitizers","volume":"175","author":"Liu","year":"2017","journal-title":"J. Photochem. Photobiol., B"},{"key":"2026100708064986500_cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2022.111925","article-title":"Synergistic Antibacterial and Wound-Healing Applications of an Imidazole-Based Porous Organic Polymer Encapsulated Silver Nanoparticles Composite","volume":"337","author":"Luo","year":"2022","journal-title":"Microporous Mesoporous Mater."},{"issue":"8","key":"2026100708064986500_cit34","doi-asserted-by":"publisher","first-page":"8989","DOI":"10.1021\/acsami.9b20102","article-title":"Bacterial Detection and Elimination Using a Dual-Functional Porphyrin-Based Porous Organic Polymer with Peroxidase-Like and High Near-Infrared-Light-Enhanced Antibacterial Activity","volume":"12","author":"Li","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026100708064986500_cit35","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.jcis.2023.05.190","article-title":"Construction of Palladium Porphyrins and Triptycene Photo-Activated Nanomaterial for Enhanced Colorimetric Detection and Inactivation of Bacteria","volume":"648","author":"Li","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"2026100708064986500_cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.128965","article-title":"Antibacterial Activity of Guanidinium-Based Ionic Covalent Organic Framework Anchoring Ag Nanoparticles","volume":"435","author":"Zhang","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"11","key":"2026100708064986500_cit37","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307695","article-title":"Photothermal and Photocatalytic Glycol Chitosan and Polydopamine-Grafted Oxygen Vacancy Bismuth Oxyiodide (BiO1\u2013xI) Nanoparticles for the Diagnosis and Targeted Therapy of Diabetic Wounds","volume":"36","author":"Kong","year":"2024","journal-title":"Adv. Mater."},{"key":"2026100708064986500_cit38","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1007\/s42864-026-00377-w","article-title":"Synergistic Multi-Target Antimicrobial Nanotherapy: Near-Infrared-Triggered Carbon-Shell Confined Quantum CoO for Efficient Photothermal Eradicating Resistant Pathogens","volume":"8","author":"Wang","year":"2026","journal-title":"Tungsten"},{"key":"2026100708064986500_cit39","doi-asserted-by":"publisher","DOI":"10.26599\/NR.2025.94907538","article-title":"NIR-II-Enhanced Pt-MoS2 Nanozymes for Synergistic Photothermal and Chemodynamic Therapy against Methicillin-Resistant Staphylococcus aureus to Promote Wound Healing","volume":"18","author":"He","year":"2025","journal-title":"Nano Res."},{"issue":"18","key":"2026100708064986500_cit40","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aee4401","article-title":"A Robust Adhesive Microneedle for Oral Infections Therapy via Synergistic Antibacterial and Neutrophil-Macrophage Axis Immunomodulation","volume":"12","author":"Wang","year":"2026","journal-title":"Sci. Adv."},{"issue":"39","key":"2026100708064986500_cit41","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.74776","article-title":"Photothermal Hydrogel with Gel\u2013Sol Transition for Programmed Antibacterial and Wound Healing","volume":"36","author":"Qi","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"47","key":"2026100708064986500_cit42","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202501242","article-title":"Sprayable Photothermal Fiber-Embedded Hydrogels to Engineer Microenvironment for Infected Wound Healing","volume":"35","author":"Du","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"2026100708064986500_cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2023.106538","article-title":"Zeta Potential Shifting Nanoemulsions Comprising Single and Gemini Tyrosine-Based Surfactants","volume":"189","author":"F\u00fcrst","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"issue":"3","key":"2026100708064986500_cit44","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202403920","article-title":"Ultralow Dose Iron-Copper Bimetallic Single-Atom Nanozymes for Efficient Photothermal-Chemodynamic Antibacterial and Wound Healing","volume":"14","author":"Zhai","year":"2025","journal-title":"Adv. Healthc. Mater."},{"issue":"4","key":"2026100708064986500_cit45","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1039\/D3TB01794J","article-title":"Co-, N-Doped Carbon Dot Nanozymes Based on an Untriggered ROS Generation Approach for Anti-Biofilm Activities and in Vivo Anti-Bacterial Treatment","volume":"12","author":"Dong","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"2026100708064986500_cit46","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jcis.2016.09.076","article-title":"Phenol-Modified Hyper-Cross-Linked Resins with Almost All Micro\/Mesopores and Their Adsorption to Aniline","volume":"487","author":"Kuang","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"2026100708064986500_cit47","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.3390\/en13061349","article-title":"Fractal Characteristics of Micro- and Mesopores in the Longmaxi Shale","volume":"16","author":"Wang","year":"2023","journal-title":"Energies"},{"key":"2026100708064986500_cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2022.154855","article-title":"Referencing to Adventitious Carbon in X-Ray Photoelectron Spectroscopy: Can Differential Charging Explain C 1s Peak Shifts?","volume":"606","author":"Greczynski","year":"2022","journal-title":"Appl. Surf. Sci."},{"key":"2026100708064986500_cit49","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s40543-025-00524-x","article-title":"Point-of-Care Colorimetric Biosensing Using 2D Co-MOFs Nanozymes for Sensitive Detection of Glucose and Hydrogen Peroxide","volume":"17","author":"Mouhamed","year":"2026","journal-title":"J. Anal. Sci. Technol."},{"issue":"101","key":"2026100708064986500_cit50","doi-asserted-by":"publisher","first-page":"83164","DOI":"10.1039\/c5ra14139g","article-title":"XPS in Development of Chemical Sensors","volume":"5","author":"Mazzotta","year":"2015","journal-title":"RSC Adv."},{"issue":"33","key":"2026100708064986500_cit51","doi-asserted-by":"publisher","first-page":"15634","DOI":"10.1021\/acs.energyfuels.5c02269","article-title":"Surface Sensitivity of Mesoporous Carbon-Supported Iron Catalysts in the Fischer\u2013Tropsch Synthesis: An in Situ XPS Site Evolution at Distinct Reaction Conditions","volume":"39","author":"Nascimento","year":"2025","journal-title":"Energy Fuels"},{"key":"2026100708064986500_cit52","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.17576\/jsm-2018-4708-33","article-title":"XPS Study of Sulfur and Phosphorus Compounds with Different Oxidation States","volume":"47","author":"Siow","year":"2018","journal-title":"Sains Malays."},{"issue":"46","key":"2026100708064986500_cit53","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202508557","article-title":"One-Step Doping of P and S Elements to Fe-ZIF-8 Derivatives for Enhanced ROS Generation and Antibacterial Application","volume":"21","author":"Cheng","year":"2025","journal-title":"Small"},{"key":"2026100708064986500_cit54","doi-asserted-by":"publisher","first-page":"3738","DOI":"10.1038\/s41467-025-58987-w","article-title":"A Dynamically Phase-Adaptive Regulating Hydrogel Promotes Ultrafast Anti-Fibrotic Wound Healing","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"2026100708064986500_cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101768","article-title":"Integrating Pt Nanoparticles with Carbon Nanodots to Achieve Robust Cascade Superoxide Dismutase-Catalase Nanozyme for Antioxidant Therapy","volume":"49","author":"Zhang","year":"2023","journal-title":"Nano Today"},{"issue":"2","key":"2026100708064986500_cit56","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.688","article-title":"Endogenous\/Exogenous Stimuli-Responsive Smart Hydrogels for Diabetic Wound Healing","volume":"6","author":"Khattak","year":"2025","journal-title":"Aggregate"},{"issue":"6","key":"2026100708064986500_cit57","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1021\/acsmaterialslett.4c00598","article-title":"A Robust Photothermal-Mediated Nanozyme Engineering with Efficient Synergistic Antibacterial Therapy for Wound Healing","volume":"6","author":"Luo","year":"2024","journal-title":"ACS Mater. Lett."},{"issue":"18","key":"2026100708064986500_cit58","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202520586","article-title":"3D-Printed Ion-Conductive Hydrogels with Tunable Mechanical-Electrical Properties for Multimodal Sign Language Recognition","volume":"13","author":"Hu","year":"2024","journal-title":"Adv. Sci."},{"issue":"15","key":"2026100708064986500_cit59","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.3390\/polym14153158","article-title":"Synthesis of Covalent Organic Frameworks (COFs)-Nanocellulose Composite and Its Thermal Degradation Studied by TGA\/FTIR","volume":"14","author":"Zhu","year":"2022","journal-title":"Polymers"},{"issue":"16","key":"2026100708064986500_cit60","doi-asserted-by":"publisher","first-page":"7489","DOI":"10.1021\/jacs.2c02408","article-title":"Outstanding Charge Mobility by Band Transport in Two-Dimensional Semiconducting Covalent Organic Frameworks","volume":"144","author":"Fu","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"52","key":"2026100708064986500_cit61","doi-asserted-by":"publisher","first-page":"35606","DOI":"10.1021\/acsnano.4c13899","article-title":"Regulating the Atomic Active Center by Covalent Organic Framework-Derived Photothermal Nanozyme to Arm Self-Gelling Powder for Bacterial Wound Healing","volume":"18","author":"Li","year":"2024","journal-title":"ACS Nano"},{"issue":"2","key":"2026100708064986500_cit62","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.70019","article-title":"Software Update: The ORCA Program System\u2014Version 6.0","volume":"15","author":"Neese","year":"2025","journal-title":"Wiley Interdiscip. Rev.: Comput. Mol. Sci."},{"issue":"7","key":"2026100708064986500_cit63","doi-asserted-by":"publisher","first-page":"5648","DOI":"10.1063\/1.464913","article-title":"Density-Functional Thermochemistry. III. The Role of Exact Exchange","volume":"98","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"issue":"2","key":"2026100708064986500_cit64","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","article-title":"Development of the Colle-Salvetti Correlation-Energy Formula into a Functional of the Electron Density","volume":"37","author":"Lee","year":"1988","journal-title":"Phys. Rev. B"},{"issue":"15","key":"2026100708064986500_cit65","doi-asserted-by":"publisher","DOI":"10.1063\/1.5090222","article-title":"A Generally Applicable Atomic-Charge Dependent London Dispersion Correction","volume":"150","author":"Caldeweyher","year":"2019","journal-title":"J. Chem. Phys."},{"issue":"18","key":"2026100708064986500_cit66","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1039\/b508541a","article-title":"Balanced Basis Sets of Split Valence, Triple Zeta Valence and Quadruple Zeta Valence Quality for H to Rn: Design and Assessment of Accuracy","volume":"7","author":"Weigend","year":"2005","journal-title":"Phys. Chem. Chem. Phys."},{"key":"2026100708064986500_cit67","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.chemphys.2008.10.036","article-title":"Efficient, Approximate and Parallel Hartree-Fock and Hybrid DFT Calculations. A \u201cChain-of-Spheres\u201d Algorithm for the Hartree-Fock Exchange","volume":"356","author":"Neese","year":"2009","journal-title":"Chem. Phys."},{"issue":"9","key":"2026100708064986500_cit68","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1039\/b515623h","article-title":"Accurate Coulomb-Fitting Basis Sets for H to Rn","volume":"8","author":"Weigend","year":"2006","journal-title":"Phys. Chem. Chem. Phys."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c17648","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/39\/54109\/68594477\/am-2026-17648k.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/39\/54109\/68594477\/am-2026-17648k.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:15:29Z","timestamp":1791375329000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/39\/54109\/5435100\/Site-Specific-Engineered-Cationic-Ferrocene-COF"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":68,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2026,9,22]]},"published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c17648","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]}}}