{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:01:56Z","timestamp":1790928116454,"version":"4.1.0"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["1R21EB016838-021"],"award-info":[{"award-number":["1R21EB016838-021"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007235","name":"Colorado State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000078","name":"Division of Materials Research","doi-asserted-by":"publisher","award":["DMR-1352201"],"award-info":[{"award-number":["DMR-1352201"]}],"id":[{"id":"10.13039\/100000078","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cu-BTTri (H3BTTri = 1,3,5-tris\u00ad[1H-1,2,3-triazol-5-yl]\u00adbenzene) is a water-stable, copper-based metal\u2013organic framework (MOF) that exhibits the ability to generate therapeutic nitric oxide (NO) from S-nitrosothiols (RSNOs) available within the bloodstream. Immobilization of Cu-BTTri within a polymeric membrane may allow for localized NO generation at the blood\u2013material interface. This work demonstrates that Cu-BTTri can be incorporated within hydrophilic membranes prepared from poly\u00ad(vinyl alcohol) (PVA), a polymer that has been examined for numerous biomedical applications. Following immobilization, the ability of the MOF to produce NO from the endogenous RSNO S-nitrosoglutathione (GSNO) is not significantly inhibited. Poly\u00ad(vinyl alcohol) membranes containing dispersions of Cu-BTTri were tested for their ability to promote NO release from a 10 \u03bcM initial GSNO concentration at pH 7.4 and 37 \u00b0C, and NO production was observed at levels associated with antithrombotic therapeutic effects without significant copper leaching (&amp;lt;1%). Over 3.5 \u00b1 0.4 h, 10 wt % Cu-BTTri\/PVA membranes converted 97 \u00b1 6% of GSNO into NO, with a maximum NO flux of 0.20 \u00b1 0.02 nmol\u00b7cm\u20132\u00b7min\u20131. Furthermore, it was observed for the first time that Cu-BTTri is capable of inducing NO production from GSNO under aerobic conditions. At pH 6.0, the NO-forming reaction of 10 wt % Cu-BTTri\/PVA membrane was accelerated by 22%, while an opposite effect was observed in the case of aqueous copper\u00ad(II) chloride. Reduced temperature (20 \u00b0C) and the presence of the thiol-blocking reagent N-ethylmaleimide (NEM) impair the NO-forming reaction of Cu-BTTri\/PVA with GSNO, with both conditions resulting in a decreased NO yield of 16 \u00b1 1% over 3.5 h. Collectively, these findings suggest that Cu-BTTri\/PVA membranes may have therapeutic utility through their ability to generate NO from endogenous substrates. Moreover, this work provides a more comprehensive analysis of the parameters that influence Cu-BTTri efficacy, permitting optimization for potential medical applications.<\/jats:p>","DOI":"10.1021\/acsami.7b11846","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T16:43:40Z","timestamp":1507135420000},"page":"35628-35641","source":"Crossref","is-referenced-by-count":53,"title":["Nitric\nOxide Generation from Endogenous Substrates\nUsing Metal\u2013Organic Frameworks: Inclusion within Poly(vinyl\nalcohol) Membranes To Investigate Reactivity and Therapeutic Potential"],"prefix":"10.1021","volume":"9","author":[{"given":"Megan\nJ.","family":"Neufeld","sequence":"first","affiliation":[{"name":"Colorado State University , , , ,","place":["Fort Collins, Colorado, United States, 80523"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"Lutzke","sequence":"additional","affiliation":[{"name":"Colorado State University , , , ,","place":["Fort Collins, Colorado, United States, 80523"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Matthew","family":"Jones","sequence":"additional","affiliation":[{"name":"Colorado State University , , , ,","place":["Fort Collins, Colorado, United States, 80523"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1836-7324","authenticated-orcid":true,"given":"Melissa M.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Colorado State University , , , ,","place":["Fort Collins, Colorado, United States, 80523"]},{"name":"Colorado State University , , , ,","place":["Fort Collins, Colorado, United States, 80523"]},{"name":"Colorado State University , , , ,","place":["Fort Collins, Colorado, United States, 80523"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,10,4]]},"reference":[{"key":"2026081800161476700_cit1","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1126\/science.1230444","article-title":"The Chemistry and\nApplications of Metal\u2013Organic Frameworks","volume":"341","author":"Furukawa","year":"2013","journal-title":"Science"},{"key":"2026081800161476700_cit2","doi-asserted-by":"publisher","first-page":"6260","DOI":"10.1002\/anie.201000048","article-title":"BioMOFs: Metal-Organic\nFrameworks for Biological and Medical Applications","volume":"49","author":"McKinlay","year":"2010","journal-title":"Angew. 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