{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:20:24Z","timestamp":1788452424377,"version":"build-2803163510"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The development of a sensitive and rapid diagnostic test for early detection of infectious viruses is urgently required to defend against pandemic and infectious diseases including seasonal influenza. In this study, we developed noble metal (Au, Pt) nanoparticle\u2013latex nanocomposite particles for use as probes for immunochromatographic test (ICT) strips. The nanocomposite particles were conjugated with monoclonal antibody (mAb) to detect an influenza A (H1N1) antigen. For comparison, Au nanoparticles conjugated with mAb were also prepared. The lowest detectable concentrations of the influenza A antigen were found to be 6.25 \u00d7 10\u20133 and 2.5 \u00d7 10\u20132 HAU\/mL for Au nanoparticle\u2013latex and Pt nanoparticle\u2013latex nanocomposite particles, respectively, whereas it was 4.0 \u00d7 10\u20131 HAU\/mL for Au nanoparticles. These results clearly demonstrated that the nanocomposite probes were more sensitive than conventional nanoparticle-based probes for ICT. To expand the versatility of the nanocomposite probes, the surfaces of the probes were functionalized with biotinylated proteins to enable modification of their surfaces with desired biotinylated antibodies through biotin\u2013avidin binding.<\/jats:p>","DOI":"10.1021\/acsami.8b11745","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T19:41:00Z","timestamp":1536176460000},"page":"31977-31987","source":"Crossref","is-referenced-by-count":43,"title":["Metal\n(Au, Pt) Nanoparticle\u2013Latex Nanocomposites as Probes for Immunochromatographic\nTest Strips with Enhanced Sensitivity"],"prefix":"10.1021","volume":"10","author":[{"given":"Yasufumi","family":"Matsumura","sequence":"first","affiliation":[{"name":"Nippon Steel & Sumikin Chemical Co., Ltd. , , 1-Tsukiji , , ,","place":["Kisarazu, Chiba, Japan, 292-0835"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Nippon Steel & Sumikin Chemical Co., Ltd. , , 1-Tsukiji , , ,","place":["Kisarazu, Chiba, Japan, 292-0835"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Japan Advanced Institute of Science and Technology , , 1-1 Asahidai , , ,","place":["Nomi, Ishikawa, Japan, 923-1292"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2669-8219","authenticated-orcid":true,"given":"Shinya","family":"Maenosono","sequence":"additional","affiliation":[{"name":"Japan Advanced Institute of Science and Technology , , 1-1 Asahidai , , ,","place":["Nomi, Ishikawa, Japan, 923-1292"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"key":"2026090310292233100_cit1","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nnano.2006.134","article-title":"Rapid and Label-Free Nanomechanical\nDetection of Biomarker Transcripts in Human RNA","volume":"1","author":"Zhang","year":"2006","journal-title":"Nat. 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