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In this scenario, an uncharted Ti-nanoMOF is originally proposed here as an oral therapeutic agent, not as a drug delivery system but as an innovative and efficient oral detoxifying agent of the challenge and timeliness salicylate intoxication (e.g., aspirin). Thus, this orally robust and biosafe Ti-nanoMOF is the only porous nanomaterial, among the six tested MOFs, able to adsorb and retain aspirin under the whole gastrointestinal tract, overpassing the capabilities of the current treatment (i.e., activated charcoal). Further, the biodistribution and bioremoval of Ti-nanoMOF have been assessed, proving a bioprotective character with an intact and almost complete removal by feces.<\/jats:p>","DOI":"10.1021\/acsami.9b06472","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T11:46:56Z","timestamp":1559130416000},"page":"22188-22193","source":"Crossref","is-referenced-by-count":45,"title":["Ti-Based\nnanoMOF as an Efficient Oral Therapeutic\nAgent"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7874-2122","authenticated-orcid":true,"given":"Sara","family":"Rojas","sequence":"first","affiliation":[{"name":"IMDEA Energy , Av. Ramo\u0301n de la Sagra 3 , ,","place":["Mo\u0301stoles-Madrid, Spain, 28935"]},{"name":"Institut Lavoisier, CNRS UMR 8180, UVSQ, Universite\u0301 Paris-Saclay , 45, Avenue Des Etats Unis , ,","place":["Versailles Cedex, France, 78035"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Guillou","sequence":"additional","affiliation":[{"name":"Institut Lavoisier, CNRS UMR 8180, UVSQ, Universite\u0301 Paris-Saclay , 45, Avenue Des Etats Unis , ,","place":["Versailles Cedex, France, 78035"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-5911","authenticated-orcid":true,"given":"Patricia","family":"Horcajada","sequence":"additional","affiliation":[{"name":"IMDEA Energy , Av. 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Toxicol."},{"key":"2026090315513616600_cit39","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.ajem.2005.12.025","article-title":"Influence\nof Activated\nCharcoal on the Pharmacokinetics and the Clinical Features of Carbamazepine\nPoisoning","volume":"24","author":"Brahmi","year":"2006","journal-title":"Am. J. Emerg. Med."},{"key":"2026090315513616600_cit40","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/15563650600907140","article-title":"Salicylate\nPoisoning: An Evidence-Based Consensus Guideline for out-of-Hospital\nManagement","volume":"45","author":"Chyka","year":"2007","journal-title":"Clin. Toxicol."},{"key":"2026090315513616600_cit41","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/nbt.1480","article-title":"Site-Specific Conjugation\nof a Cytotoxic Drug to an Antibody Improves the Therapeutic Index","volume":"26","author":"Junutula","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"2026090315513616600_cit42","first-page":"11","article-title":"Protective\nEffects of Ginger against\nAspirin-Induced Gastric Ulcers in Rats","volume":"54","author":"Wang","year":"2011","journal-title":"Yonago\nActa Med."},{"key":"2026090315513616600_cit43","first-page":"151","article-title":"Digestion\nand the Structure and Function of the Gut","volume":"8","author":"Rose","year":"1987","journal-title":"J.\nAnat."},{"key":"2026090315513616600_cit44","volume-title":"J. Drug Therapy\nin Nursing","author":"Ascjenbrenner","year":"2009"},{"key":"2026090315513616600_cit45","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.ijpharm.2016.08.010","article-title":"In vivo Behavior of MIL-100 Nanoparticles at Early\nTimes after Intravenous Administration","volume":"511","author":"Simon-Yarza","year":"2016","journal-title":"Int.\nJ. Pharm."},{"key":"2026090315513616600_cit46","first-page":"286","article-title":"Toxicity\nof Nanomaterials on\nthe Liver, Kidney, and Spleen","volume-title":"Biointeractions\nof Nanomaterials","author":"Patel","year":"2015"},{"key":"2026090315513616600_cit47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1743-8977-11-30","article-title":"Tissue Distribution and Elimination after Oral and\nIntravenous Administration of Different Titanium Dioxide Nanoparticles\nin Rats","volume":"11","author":"Geraets","year":"2014","journal-title":"Part. 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