{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:46:24Z","timestamp":1789994784667,"version":"4.0.1"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100011263","name":"FP7 Nanosciences, Nanotechnologies, Materials and new Production Technologies","doi-asserted-by":"publisher","award":["281035"],"award-info":[{"award-number":["281035"]}],"id":[{"id":"10.13039\/100011263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["13\/RC\/2073"],"award-info":[{"award-number":["13\/RC\/2073"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["16\/TIDA\/3936"],"award-info":[{"award-number":["16\/TIDA\/3936"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2020,1,8]]},"DOI":"10.1021\/acsami.9b16104","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T11:44:52Z","timestamp":1575546292000},"page":"1257-1269","source":"Crossref","is-referenced-by-count":33,"title":["Silica-Coated Nanoparticles with a Core of Zinc, <scp>l<\/scp>-Arginine, and a Peptide Designed for Oral Delivery"],"prefix":"10.1021","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1010-7966","authenticated-orcid":true,"given":"Delyan","family":"Hristov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"McCartney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Beirne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Mahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6528-6877","authenticated-orcid":true,"given":"Sourav","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Penarier","sequence":"additional","affiliation":[{"name":"Sanofi Recherche & D\u00e9veloppement, PSO\/LGCR, B\u00e2timent BLP, rue du Pr Blayac, 34184 Montpellier Cedex 4, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Werner","sequence":"additional","affiliation":[{"name":"Sanofi-Aventis Deutschland GmbH. Industriepark H\u00f6chst, K703 65926 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Bazile","sequence":"additional","affiliation":[{"name":"Sanofi Recherche & D\u00e9veloppement, CMC External Innovation, 82, avenue Raspail, 94250 Gentilly Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-8344","authenticated-orcid":true,"given":"David J.","family":"Brayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24040809"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.01.010"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1111\/jan.13818"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1530\/eje-15-1042"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12977"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12852"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2016.1156804"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(18)30372-3"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2942"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00838"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.02.004"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.183"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aar7047"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4113"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2016.1176822"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.10.026"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.01.018"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.11.005"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.02.024"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.03.004"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.10.022"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2018.09.023"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(76)91209-5"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.2.246"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007049"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.16.43"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2012.06.014"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.04.024"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2015.03.027"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.07.049"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.06.051"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00290"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11030129."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2018.1503250"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2018.04.064"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.8b06557"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.01.066"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2018.10.013"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.08.008"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.09.091"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.06.011"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2017.11.015"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.8b02785"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2018.02.004"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/ar3000986"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1039\/c6nr09331k"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.09.006"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.10.002"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-018-0246-4"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2578-7"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a003261"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.06.005"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.07.001"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2016.09.029"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.016"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.07.007"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.10.026"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.03.010"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39107-3"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.9b16104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T17:05:14Z","timestamp":1681751114000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.9b16104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,5]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,8]]}},"alternative-id":["10.1021\/acsami.9b16104"],"URL":"https:\/\/doi.org\/10.1021\/acsami.9b16104","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,5]]}}}