{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:45:29Z","timestamp":1793882729546,"version":"4.7.0"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccbyncnd_termsofuse.html"}],"funder":[{"DOI":"10.13039\/na","name":"Health~Holland","doi-asserted-by":"publisher","award":["LSHM18026"],"award-info":[{"award-number":["LSHM18026"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The complex reconstructive surgeries for which patient-specific orthopedic, maxillofacial, or dental implants are used often necessitate wounds that are open for a considerable amount of time. Unsurprisingly, this allows bacteria to establish implant-associated infection, despite the scrupulous sterilization efforts made during surgery. Here, we developed a prophylactic bactericidal coating via electrophoretic deposition technology for two 3D-printed porous titanium implant designs. The surface characteristics, antibiotic release behavior, antibacterial properties, and impact on osteoblast cell proliferation of the optimized coatings were investigated. The results unequivocally confirmed the biofunctionality of the implants in vitro. This study reveals a new avenue for future antibacterial patient-specific implants.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.0c00683","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T23:03:06Z","timestamp":1599519786000},"page":"5486-5492","source":"Crossref","is-referenced-by-count":37,"title":["Toward Antibacterial Coatings for Personalized Implants"],"prefix":"10.1021","volume":"6","author":[{"given":"F.","family":"Jahanmard","sequence":"first","affiliation":[{"name":"University Medical Center Utrecht , , ,","place":["Utrecht, The Netherlands, 3584 CX"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Dijkmans","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht , , ,","place":["Utrecht, The Netherlands, 3584 CX"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Majed","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht , , ,","place":["Utrecht, The Netherlands, 3584 CX"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.C.","family":"Vogely","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht , , ,","place":["Utrecht, The Netherlands, 3584 CX"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.C.H.","family":"van der Wal","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht , , ,","place":["Utrecht, The Netherlands, 3584 CX"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.C.","family":"Stapels","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht , , ,","place":["Utrecht, The Netherlands, 3584 CX"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Amber Implants B.V. , ,","place":["Delft, The Netherlands, 2629 JD"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6047-5900","authenticated-orcid":true,"given":"T.","family":"Vermonden","sequence":"additional","affiliation":[{"name":"Utrecht University , , ,","place":["Utrecht, The Netherlands, 3584 CS"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1677-5751","authenticated-orcid":true,"given":"S.","family":"Amin Yavari","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht , , ,","place":["Utrecht, The Netherlands, 3584 CX"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"issue":"5418","key":"2026090300144763000_cit1","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial\nbiofilms: a common cause\nof persistent infections","volume":"284","author":"Costerton","year":"1999","journal-title":"Science"},{"issue":"6","key":"2026090300144763000_cit2","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1128\/JCM.37.6.1771-1776.1999","article-title":"The Calgary\nBiofilm Device: new technology for rapid determination\nof antibiotic susceptibilities of bacterial biofilms","volume":"37","author":"Ceri","year":"1999","journal-title":"J. Clin. Microbiol."},{"issue":"4","key":"2026090300144763000_cit3","doi-asserted-by":"publisher","first-page":"e163","DOI":"10.1016\/S2589-7500(19)30067-6","article-title":"Challenges in the\ndesign and regulatory\napproval of 3D-printed surgical implants: a two-case series","volume":"1","author":"Willemsen","year":"2019","journal-title":"Lancet Digital Health"},{"issue":"1","key":"2026090300144763000_cit4","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s40121-017-0146-1","article-title":"Infections\nin cancer patients with solid tumors: a review","volume":"6","author":"Rolston","year":"2017","journal-title":"Infect Dis Ther"},{"issue":"1","key":"2026090300144763000_cit5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1186\/s12891-017-1742-7","article-title":"Silver-coated\nmodular Megaendoprostheses\nin salvage revision arthroplasty after periimplant infection with\nextensive bone loss \u2013 a pilot study of 34 patients","volume":"18","author":"Zajonz","year":"2017","journal-title":"BMC Musculoskeletal Disord."},{"issue":"1","key":"2026090300144763000_cit6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41413-018-0032-9","article-title":"Advanced\nsmart\nbiomaterials and constructs for hard tissue engineering and regeneration","volume":"6","author":"Zhang","year":"2018","journal-title":"Bone Res."},{"key":"2026090300144763000_cit7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.carbpol.2014.12.027","article-title":"Mechanically stable\nantimicrobial\nchitosan\u2013PVA\u2013silver nanocomposite coatings deposited\non titanium implants","volume":"121","author":"Mishra","year":"2015","journal-title":"Carbohydr. Polym."},{"issue":"10","key":"2026090300144763000_cit8","doi-asserted-by":"publisher","first-page":"4024","DOI":"10.1021\/am200891f","article-title":"Water-Repellent Cellulose Fiber Networks\nwith Multifunctional\nProperties","volume":"3","author":"Bayer","year":"2011","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"2026090300144763000_cit9","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1021\/acsbiomaterials.6b00306","article-title":"Surface Modification\nof Polymeric Biomaterials Using Recombinant Spider Silk Proteins","volume":"3","author":"Borkner","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"2026090300144763000_cit10","doi-asserted-by":"publisher","first-page":"100991","DOI":"10.1016\/j.addma.2019.100991","article-title":"Layer by layer coating\nfor bio-functionalization of additively manufactured meta-biomaterials","volume":"32","author":"Amin Yavari","year":"2020","journal-title":"Addit. Manuf."},{"issue":"12","key":"2026090300144763000_cit11","doi-asserted-by":"publisher","first-page":"4112","DOI":"10.1021\/acsbiomaterials.8b01184","article-title":"PEO\/Mg\u2013Zn\u2013Al LDH Composite\nCoating on Mg Alloy as a Zn\/Mg Ion-Release Platform with Multifunctions:\nEnhanced Corrosion Resistance, Osteogenic, and Antibacterial Activities","volume":"4","author":"Peng","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"37","key":"2026090300144763000_cit12","doi-asserted-by":"publisher","first-page":"5845","DOI":"10.1039\/C8TB01363B","article-title":"Direct covalent\nattachment of silver nanoparticles on radical-rich plasma polymer\nfilms for antibacterial applications","volume":"6","author":"Akhavan","year":"2018","journal-title":"J. Mater.\nChem. 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Interfaces"},{"key":"2026090300144763000_cit18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.actbio.2018.09.051","article-title":"Antibacterial and immunogenic behavior\nof silver coatings on additively manufactured porous titanium","volume":"81","author":"Croes","year":"2018","journal-title":"Acta Biomater."},{"issue":"9\u201310","key":"2026090300144763000_cit19","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1089\/ten.tea.2014.0476","article-title":"Osteostatin-coated\nporous titanium can improve early bone regeneration of cortical bone\ndefects in rats","volume":"21","author":"Van Der Stok","year":"2015","journal-title":"Tissue Eng., Part A"},{"issue":"7","key":"2026090300144763000_cit20","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1002\/mabi.201500005","article-title":"Influence\nof the molecular weight and charge of antibiotics on their release\nkinetics from gelatin nanospheres","volume":"15","author":"Song","year":"2015","journal-title":"Macromol.\nBiosci."},{"issue":"1","key":"2026090300144763000_cit21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3109\/10717544.2012.746402","article-title":"Development of gentamicin-gold nanospheres for antimicrobial\ndrug delivery to Staphylococcal infected foci","volume":"20","author":"Ahangari","year":"2013","journal-title":"Drug Delivery"},{"key":"2026090300144763000_cit22","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.surfcoat.2019.02.075","article-title":"Effect of\nshot-blasting pretreatment on microstructures of hot-dip galvanized\ncoating","volume":"364","author":"Li","year":"2019","journal-title":"Surf. Coat. Technol."},{"issue":"149","key":"2026090300144763000_cit23","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00149","article-title":"Personalized\nHealth Systems\u2500Past,\nPresent, and Future of Research Development and Implementation in\nReal-Life Environment","volume":"6","author":"Lewy","year":"2019","journal-title":"Front. Med."},{"issue":"2","key":"2026090300144763000_cit24","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1302\/0301-620X.97B2.34554","article-title":"Retrospective evaluation of the incidence\nof early periprosthetic infection with silver-treated endoprostheses\nin high-risk patients: case-control study","volume":"97","author":"Wafa","year":"2015","journal-title":"Bone\nJt. J."},{"key":"2026090300144763000_cit25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.pmatsci.2019.01.001","article-title":"Electrophoretic deposition of chitosan-based\ncomposite\ncoatings for biomedical applications: A review","volume":"103","author":"Avcu","year":"2019","journal-title":"Prog. Mater. Sci."},{"issue":"10","key":"2026090300144763000_cit26","doi-asserted-by":"publisher","first-page":"3355","DOI":"10.1021\/bm401021b","article-title":"Electrophoretic Deposition of Biological\nMacromolecules,\nDrugs, And Cells","volume":"14","author":"Seuss","year":"2013","journal-title":"Biomacromolecules"},{"key":"2026090300144763000_cit27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.matlet.2018.12.042","article-title":"Electrophoretic deposition\nof core-shell\nAg@MSN incorporated-chitosan coatings with biocompatible and antibacterial\nactivities","volume":"239","author":"Li","year":"2019","journal-title":"Mater. Lett."},{"key":"2026090300144763000_cit28","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.msec.2015.04.031","article-title":"Electrodeposition\nof chitosan\/gelatin\/nanosilver:\nA new method for constructing biopolymer\/nanoparticle composite films\nwith conductivity and antibacterial activity","volume":"53","author":"Wang","year":"2015","journal-title":"Mater. Sci. Eng., C"},{"issue":"6","key":"2026090300144763000_cit29","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/adem.201100344","article-title":"Surface Modification of Ti6Al4V Open\nPorous Structures Produced by Additive Manufacturing","volume":"14","author":"Pyka","year":"2012","journal-title":"Adv. Eng. Mater."},{"key":"2026090300144763000_cit30","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.addma.2019.06.014","article-title":"Effect of ultrasonic\nshot peening\non the surface defects of thin struts built by electron beam melting:\nConsequences on fatigue resistance","volume":"28","author":"Persenot","year":"2019","journal-title":"Addit. Manuf."},{"issue":"7","key":"2026090300144763000_cit31","doi-asserted-by":"publisher","first-page":"1801140","DOI":"10.1002\/adem.201801140","article-title":"Enhancing\nthe Structural Performance of Lightweight Metals by Shot Peening","volume":"21","author":"Bagherifard","year":"2019","journal-title":"Adv. Eng. Mater."},{"key":"2026090300144763000_cit32","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.biomaterials.2015.09.019","article-title":"The influence of nanostructured features\non bacterial adhesion and bone cell functions on severely shot peened\n316L stainless steel","volume":"73","author":"Bagherifard","year":"2015","journal-title":"Biomaterials"},{"issue":"1","key":"2026090300144763000_cit33","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1021\/acsbiomaterials.7b00544","article-title":"Inhibition\nof Bacterial Adhesion on Nanotextured Stainless Steel 316L by Electrochemical\nEtching","volume":"4","author":"Jang","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"5","key":"2026090300144763000_cit34","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1021\/acsbiomaterials.8b00173","article-title":"Enhanced Mechanical and Biological Performance of an\nExtremely Fine Nanograined 316L Stainless Steel Cell\u2013Substrate\nInterface Fabricated by Ultrasonic Shot Peening","volume":"4","author":"Yin","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"13","key":"2026090300144763000_cit35","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1016\/j.biomaterials.2010.01.071","article-title":"The influence of\nnano-scale surface roughness on bacterial adhesion to ultrafine-grained\ntitanium","volume":"31","author":"Truong","year":"2010","journal-title":"Biomaterials"},{"issue":"4","key":"2026090300144763000_cit36","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.biomaterials.2010.10.001","article-title":"Differential\nresponse of Staphylococci and osteoblasts to varying titanium surface\nroughness","volume":"32","author":"Wu","year":"2011","journal-title":"Biomaterials"},{"key":"2026090300144763000_cit37","doi-asserted-by":"publisher","first-page":"119737","DOI":"10.1016\/j.biomaterials.2019.119737","article-title":"Accepting\nhigher morbidity in exchange for sacrificing fewer animals in studies\ndeveloping novel infection-control strategies","volume":"232","author":"Busscher","year":"2020","journal-title":"Biomaterials"}],"container-title":["ACS Biomaterials Science &amp; Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.0c00683","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/abseba\/article-pdf\/6\/10\/5486\/67126665\/acsbiomaterials.0c00683.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/abseba\/article-pdf\/6\/10\/5486\/67126665\/acsbiomaterials.0c00683.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:24:45Z","timestamp":1788409485000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/abseba\/article\/6\/10\/5486\/470871\/Toward-Antibacterial-Coatings-for-Personalized"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,7]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,9,7]]},"published-print":{"date-parts":[[2020,10,12]]}},"URL":"https:\/\/doi.org\/10.1021\/acsbiomaterials.0c00683","relation":{},"ISSN":["2373-9878"],"issn-type":[{"value":"2373-9878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,7]]}}}