{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T15:25:40Z","timestamp":1792337140390,"version":"4.4.0"},"reference-count":163,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Minist??rio da Ci??ncia, Tecnologia e Inova????o","doi-asserted-by":"publisher","award":["309212\/2019-7"],"award-info":[{"award-number":["309212\/2019-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Minist??rio da Ci??ncia, Tecnologia e Inova????o","doi-asserted-by":"publisher","award":["465389\/2014-7"],"award-info":[{"award-number":["465389\/2014-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo","doi-asserted-by":"publisher","award":["2017\/01189-0"],"award-info":[{"award-number":["2017\/01189-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo","doi-asserted-by":"publisher","award":["2018\/11657-4"],"award-info":[{"award-number":["2018\/11657-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo","doi-asserted-by":"publisher","award":["2018\/18188-0"],"award-info":[{"award-number":["2018\/18188-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo","doi-asserted-by":"publisher","award":["2018\/19750-3"],"award-info":[{"award-number":["2018\/19750-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior","doi-asserted-by":"publisher","award":["88887.504531\/2020-00"],"award-info":[{"award-number":["88887.504531\/2020-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Biomater. Sci. Eng."],"published-print":{"date-parts":[[2023,5,8]]},"DOI":"10.1021\/acsbiomaterials.2c01454","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T14:12:37Z","timestamp":1680617557000},"page":"2220-2234","source":"Crossref","is-referenced-by-count":23,"title":["Organ-on-a-Chip for Drug Screening: A Bright Future for Sustainability? A Critical Review"],"prefix":"10.1021","volume":"9","author":[{"given":"J\u00e9ssica F.","family":"Feitor","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, 13566-590 S\u00e3o Carlos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-7552","authenticated-orcid":true,"given":"La\u00eds C.","family":"Brazaca","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, 13566-590 S\u00e3o Carlos, SP, Brazil"},{"name":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, 02138 Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Lima","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, 13566-590 S\u00e3o Carlos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius G.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, 13566-590 S\u00e3o Carlos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Kassab","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, 13566-590 S\u00e3o Carlos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderlei S.","family":"Bagnato","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, 13566-590 S\u00e3o Carlos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7351-8220","authenticated-orcid":true,"given":"Emanuel","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, 13566-590 S\u00e3o Carlos, SP, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Bioanal\u00edtica\u2212INCTBio, 13083-970 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-3327","authenticated-orcid":true,"given":"Daniel R.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, 13566-590 S\u00e3o Carlos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0079-3"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-020-02407-z"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.09.022"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/1747-5341-4-2"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2006.11.001"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3681"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00503"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4539"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/S1872-2040(16)60920-9"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2011.09.005"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2989"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/mi9100536"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nature05058"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.06.003"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.11.009"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-020-0752-0"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/genes10010047"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222878110"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4609"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2014.573"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/528479c"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1099\/acmi.0.000173"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2018.12.001"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-125-7_14"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-101512-122340"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.049"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0051-9"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ac402761s"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.08.037"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188302"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/C7LC01357D"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2019.1710458"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1177\/2041731420965318"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120196"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201701545"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31106"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00575.2016"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1063\/1.5120555"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76062-w"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c00076"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-817202-5.00007-3"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/srep31771"},{"key":"ref43\/cit43","unstructured":"Organ-on-a-Chip\n- Cross-flow membrane - Mini Luer\u2013 Darwin Microfluidics. 2023, https:\/\/darwin-microfluidics.com\/products\/organ-on-chip-cross-flow-membrane-mini-luer."},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0760-y"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00297"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1039\/c3ib40049b"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2018.0351"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-102194-1.00005-0"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.9b00753"},{"key":"ref50\/cit50","unstructured":"Dow SYLGARD\n184 Silicone Encapsulant Clear 0.5 kg Kit. 2023, https:\/\/www.ellsworth.com\/products\/by-market\/consumer-products\/encapsulants\/silicone\/dow-sylgard-184-silicone-encapsulant-clear-0.5-kg-kit\/."},{"key":"ref51\/cit51","unstructured":"DOW SYLGARD\n184 SILICONE ELASTOMER CLEAR 0.5KG (1.1LB). 2017, https:\/\/krayden.com\/buy\/sylgard-184-0-5kg-1-1lb-kit-dc4019862.html."},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3390\/mi12121443"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11485-6"},{"key":"ref54\/cit54","unstructured":"Degradation of\nSilicone\nPolymers in Nature\n                      . 1998, http:\/\/www.green-flow.co.il\/Documents\/Aquatain%20AMF\/%D7%9E%D7%97%D7%A7%D7%A8%D7%99%D7%9D%20%D7%95%D7%A0%D7%99%D7%A1%D7%95%D7%99%20%D7%A9%D7%98%D7%97\/Degradation%20of%20Silicone%20Polymers%20in%20Nature.pdf."},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(99)00430-0"},{"key":"ref56\/cit56","unstructured":"Is Silicone\nBiodegradable Or Recyclable? Almost Zero Waste. https:\/\/www.almostzerowaste.com\/does-silicone-break-down\/ (accessed April 03, 2023)."},{"key":"ref57\/cit57","unstructured":"Glass\nPrice Calculator. 2023, https:\/\/www.crystalglassny.com\/Store\/Glass-Products-Info."},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2018.10.019"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-396459-5.00014-3"},{"key":"ref60\/cit60","unstructured":"How Long\nDoes it Take for a Glass Bottle to Degrade in a Landfill? https:\/\/education.seattlepi.com\/long-glass-bottle-degrade-landfill-5235.html (accessed April 03, 2023)."},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1039\/C6LC01319H"},{"key":"ref62\/cit62","unstructured":"How Much\nDo Acrylic Sheets Cost? | HowMuchIsIt.org. 2022, https:\/\/www.howmuchisit.org\/acrylic-sheets-cost\/."},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3390\/polym12102198"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4570"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1063\/1.5083138"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3390\/mi10120849"},{"key":"ref67\/cit67","unstructured":"https:\/\/www.eppendorf.com\/product-media\/doc\/en\/90696\/Eppendorf_Consumables_Technical-data_Cell-Culture-Plate-96-Well.pdf, 2013 (accessed April 03, 2023)."},{"key":"ref68\/cit68","unstructured":"SynALI\nAir-Liquid Interface Lung Model\u2013 Darwin Microfluidics. 2023, https:\/\/darwin-microfluidics.com\/products\/synali-air-liquid-interface-lung-model."},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00640"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1038\/532435a"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2022.120261"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2017.07.144"},{"key":"ref73\/cit73","first-page":"204","volume":"36","author":"Iliescu C.","year":"2006","journal-title":"Informacije MIDEM"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.3390\/mi9080409"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1063\/1.3466882"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111972"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2021.100309"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.3390\/bios9030110"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.coelec.2019.05.014"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522556113"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax0729"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00323-0"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2016.04.003"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2018.02.004"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1063\/5.0011583"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1126\/science.adg6276"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-03569-9"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.14573\/altex.2001241"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1039\/C4LC00071D"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1039\/b602036d"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1002\/bit.21360"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00790J"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1038\/srep24598"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25659"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1039\/C5LC00874C"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1039\/c3lc50252j"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1039\/C1IB00087J"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1039\/C5LC01356A"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1063\/1.5034791"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.02.045"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3697"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0397-0"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21201-7"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.04.037"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119367"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-019-02598-0"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.118.082958"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201240109"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.3390\/mi12121528"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201603737"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2018.02.011"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b00686"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1039\/C4LC00069B"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0325"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.711307"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.10.003"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1101\/806505"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00957K"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1039\/C6LC00702C"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8020019"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1186\/s13561-021-00302-6"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1016\/j.phanu.2018.02.001"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-020-00030-2"},{"key":"ref124\/cit124","unstructured":"Research\nand Development in the Pharmaceutical Industry | Congressional Budget\nOffice. 2021, https:\/\/www.cbo.gov\/publication\/57126."},{"key":"ref125\/cit125","unstructured":"2020 PhRMA\nAnnual Membership\nSurvey."},{"key":"ref126\/cit126","unstructured":"Global\nOrgan-On-Chip (OOC) Opportunities And Strategies Market Report. 2021, https:\/\/www.thebusinessresearchcompany.com\/report\/organ-on-chip-market."},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217715441"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2021.06.015"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.14573\/altex.1908271"},{"key":"ref130\/cit130","unstructured":"Organ-on-chip\nMarket | 2022 - 27 | Industry Share, Size, Growth - Mordor Intelligence. 2022, https:\/\/www.mordorintelligence.com\/industry-reports\/organs-on-chips-market."},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.11.009"},{"key":"ref132\/cit132","volume-title":"Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip","author":"Li X.","year":"2021","edition":"1"},{"key":"ref133\/cit133","unstructured":"Emulate\n- Crunchbase Company Profile & Funding. 2023, https:\/\/www.crunchbase.com\/organization\/emulate."},{"key":"ref134\/cit134","unstructured":"Emulate,\nInc. and AstraZeneca Form Strategic Agreement to Work Side-by-Side\non Organs-on-Chips Technology to Improve Prediction of Human Safety\nand Efficacy of Drug Candidates | Business Wire. 2018, https:\/\/www.businesswire.com\/news\/home\/20180516005544\/en\/Emulate-Inc.and-AstraZeneca-Form-Strategic-Agreement-to-Work-Side-by-Side-on-Organs-on-Chips-Technology-to-Improve-Prediction-of-Human-Safety-and-Efficacy-of-Drug-Candidates."},{"key":"ref135\/cit135","unstructured":"Roche\nIn Strategic Partnership With Emulate For Drug Discovery Platform\n- Drug Discovery and Development. 2018, https:\/\/www.drugdiscoverytrends.com\/roche-in-strategic-partnership-with-emulate-for-drug-discovery-platform\/."},{"key":"ref136\/cit136","unstructured":"TissUse\nannounces new partnership with leading pharmaceutical company to develop\napplications for its Multi-Organ-Chip platform in drug research and\ndevelopment | Cluster Gesundheitswirtschaft Berlin-Brandenburg. 2018, https:\/\/www.healthcapital.de\/news\/artikel\/tissuse-announces-new-partnership-with-leading-pharmaceutical-company-to-develop-applications-for-it\/."},{"key":"ref137\/cit137","unstructured":"TissUse\nReports Progress Made in Collaboration With AstraZeneca | BioSpace. 2018, https:\/\/www.biospace.com\/article\/releases\/tissuse-reports-progress-made-in-collaboration-with-astrazeneca\/."},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.3390\/mi7120225"},{"key":"ref139\/cit139","doi-asserted-by":"publisher","DOI":"10.1016\/j.coche.2019.10.006"},{"key":"ref140\/cit140","unstructured":"Fluidigm\nAnnounces Preliminary Revenue Exceeding Guidance for the Fourth Quarter\nand Full Year 2021 | Standard BioTools Inc. 2022, https:\/\/investors.fluidigm.com\/news-releases\/news-release-details\/fluidigm-announces-preliminary-revenue-exceeding-guidance-fourth."},{"key":"ref141\/cit141","unstructured":"Emulate,\nInc. Company Profile | Boston, MA | Competitors, Financials &\nContacts - Dun & Bradstreet. https:\/\/www.dnb.com\/business-directory\/company-profiles.emulate_inc.e02f1c72a411366161e332e00d2c3a6a.html (accessed April 03, 2023)."},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-019-0260-7"},{"key":"ref143\/cit143","unstructured":"Research\nand Innovation Overall Rankings - Biochemistry, Genetics and Molecular\nBiology, 2022. https:\/\/www.scimagoir.com\/rankings.php?area=1300."},{"key":"ref144\/cit144","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2015.04.024"},{"key":"ref145\/cit145","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2019.01.036"},{"key":"ref146\/cit146","unstructured":"What\nis a circular economy? | Ellen MacArthur Foundation. https:\/\/ellenmacarthurfoundation.org\/topics\/circular-economy-introduction\/overview (accessed April 03, 2023)."},{"key":"ref147\/cit147","doi-asserted-by":"publisher","DOI":"10.1108\/01443570110410865"},{"key":"ref148\/cit148","doi-asserted-by":"publisher","DOI":"10.1108\/14676371111148054"},{"key":"ref149\/cit149","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0836(199909\/10)8:5<255::AID-BSE214>3.0.CO;2-O"},{"key":"ref150\/cit150","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2019.06.028"},{"key":"ref151\/cit151","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2016.12.048"},{"key":"ref152\/cit152","unstructured":"Macarthur, E.\n                      Founding Partners of the TOWARDS THE CIRCULAR ECONOMY Economic and business rationale for an accelerated transition\n                      ; 2013, Vol. 1, p. 242013. https:\/\/ellenmacarthurfoundation.org\/towards-the-circular-economy-vol-1-an-economic-and-business-rationale-for-an (accessed April 03, 2023)."},{"key":"ref153\/cit153","doi-asserted-by":"publisher","DOI":"10.1039\/C6LC01554A"},{"key":"ref154\/cit154","unstructured":"5 Top\nEmerging Organ-on-a-Chip Startups Impacting The Pharma Sector. https:\/\/www.startus-insights.com\/innovators-guide\/5-top-emerging-organ-on-a-chip-ooc-startups-impacting-the-pharma-sector\/ (accessed April 03, 2023)."},{"key":"ref155\/cit155","unstructured":"Silicone\nRubber Recycling Process | ECO USA. 2018, https:\/\/www.ecousarecycling.com\/silicone-rubber-recycling-process."},{"key":"ref156\/cit156","doi-asserted-by":"publisher","DOI":"10.3390\/polym13010158"},{"key":"ref157\/cit157","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2015.1107093"},{"key":"ref158\/cit158","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2017.05.026"},{"key":"ref159\/cit159","volume-title":"Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications","author":"Freshney R. I.","year":"2016"},{"key":"ref160\/cit160","unstructured":"Other\nSterilization Methods | Disinfection & Sterilization Guidelines\n| Guidelines Library | Infection Control | CDC. 2008, https:\/\/www.cdc.gov\/infectioncontrol\/guidelines\/disinfection\/sterilization\/other-methods.html."},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.1021\/acsphotonics.0c01245"},{"key":"ref162\/cit162","unstructured":"Ethylene\nOxide Sterilization for Medical Devices | FDA. 2022, https:\/\/www.fda.gov\/medical-devices\/general-hospital-devices-and-supplies\/ethylene-oxide-sterilization-medical-devices."},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-022-00118-6"}],"container-title":["ACS Biomaterials Science &amp; Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.2c01454","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.2c01454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T04:23:57Z","timestamp":1683519837000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsbiomaterials.2c01454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,4]]},"references-count":163,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,8]]}},"alternative-id":["10.1021\/acsbiomaterials.2c01454"],"URL":"https:\/\/doi.org\/10.1021\/acsbiomaterials.2c01454","relation":{},"ISSN":["2373-9878","2373-9878"],"issn-type":[{"value":"2373-9878","type":"print"},{"value":"2373-9878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,4]]}}}