{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:12:14Z","timestamp":1792872734781,"version":"4.5.0"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100007322","name":"Binzhou Medical University","doi-asserted-by":"publisher","award":["BY2019KYQD29"],"award-info":[{"award-number":["BY2019KYQD29"]}],"id":[{"id":"10.13039\/501100007322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022ME168"],"award-info":[{"award-number":["ZR2022ME168"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Disruption of the symbiosis of extra\/intratumoral metabolism is a good strategy for treating tumors that shuttle resources from the tumor microenvironment. Here, we report a precision treatment strategy for enhancing pyruvic acid and intratumoral acidosis to destroy tumoral metabolic symbiosis to eliminate tumors; this approach is based on PEGylated gold and lactate oxidase-modified aminated dendritic mesoporous silica with lonidamine and ferrous sulfide loading (PEG-Au@DMSNs\/FeS\/LND@LOX). In the tumor microenvironment, LOX oxidizes lactic acid to produce pyruvate, which represses tumor cell proliferation by inhibiting histone gene expression and induces ferroptosis by partial histone monoubiquitination. In acidic tumor conditions, the nanoparticles release H2S gas and Fe2+ ions, which can inhibit catalase activity to promote the Fenton reaction of Fe2+, resulting in massive \u00b7OH production and ferroptosis via Fe3+. More interestingly, the combination of H2S and LND (a monocarboxylic acid transporter inhibitor) can cause intracellular acidosis by lactate, and protons overaccumulate in cells. Multiple intracellular acidosis is caused by lactate-pyruvate axis disorders. Moreover, H2S provides motive power to intensify the shuttling of nanoparticles in the tumor region. The findings confirm that this nanomedicine system can enable precise antitumor effects by disrupting extra\/intratumoral metabolic symbiosis and inducing ferroptosis and represents a promising active drug delivery system candidate for tumor treatment.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.3c01665","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:33:41Z","timestamp":1715560421000},"page":"3994-4008","source":"Crossref","is-referenced-by-count":20,"title":["H2S\u2011Powered Nanomotors for Active\nTherapy of Tumors by Inducing Ferroptosis and Lactate-Pyruvate Axis\nDisorders"],"prefix":"10.1021","volume":"10","author":[{"given":"Weixin","family":"Wang","sequence":"first","affiliation":[{"name":"Binzhou Medical University , , , ,","place":["Yantai, PR China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renquan","family":"Fu","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[{"name":"Binzhou Medical University , , , ,","place":["Yantai, PR China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Luo","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 200240"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongchao","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Medical University , , , ,","place":["Taiyuan, PR China, 030001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Xue","sequence":"additional","affiliation":[{"name":"Xi\u2019an Medical University , , ,","place":["Xi\u2019an, PR China, 710000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Sun","sequence":"additional","affiliation":[{"name":"Binzhou Medical University , , , ,","place":["Yantai, PR China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Pan","sequence":"additional","affiliation":[{"name":"Binzhou Medical University , , , ,","place":["Yantai, PR China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaofang","family":"Hong","sequence":"additional","affiliation":[{"name":"Binzhou Medical University , , , ,","place":["Yantai, PR China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Binzhou Medical University , , , ,","place":["Yantai, PR China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Qiao","sequence":"additional","affiliation":[{"name":"Binzhou Medical University , , , ,","place":["Yantai, PR China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibing","family":"Mei","sequence":"additional","affiliation":[{"name":"Southwest Medical University , , , ,","place":["Luzhou, China, 646000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Wu","sequence":"additional","affiliation":[{"name":"Southwest Medical University , , , ,","place":["Luzhou, China, 646000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yini","family":"Wang","sequence":"additional","affiliation":[{"name":"Binzhou Medical University , , , ,","place":["Yantai, PR China, 264003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Zhong","sequence":"additional","affiliation":[{"name":"Southwest University of Science and Technology , ,","place":["Mianyang, China, 621000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Hainan University , , ,","place":["Haikou, China, 570228"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-9778","authenticated-orcid":true,"given":"Fei","family":"Tong","sequence":"additional","affiliation":[{"name":"Binzhou Medical University , , , ,","place":["Yantai, PR China, 264003"]},{"name":"Southwest Medical University , , , ,","place":["Luzhou, China, 646000"]},{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"2026081411103970600_cit1","doi-asserted-by":"publisher","first-page":"188314","DOI":"10.1016\/j.bbcan.2019.188314","article-title":"Challenges\nin liver cancer and possible treatment approaches. 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