{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:40:49Z","timestamp":1786722049907,"version":"build-2736575974"},"reference-count":103,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100023360","name":"St Vincent's Hospital Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["140100012 CE"],"award-info":[{"award-number":["140100012 CE"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT230100220"],"award-info":[{"award-number":["FT230100220"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study investigates the electrochemical behavior of GelMA-based hydrogels and their interactions with PC12 neural cells under electrical stimulation in the presence of conducting substrates. Focusing on indium tin oxide (ITO), platinum, and gold mylar substrates supporting conductive scaffolds composed of hydrogel, graphene oxide, and gold nanorods, we explored how the substrate materials affect scaffold conductivity and cell viability. We examined the impact of an optimized electrical stimulation protocol on the PC12 cell viability. According to our findings, substrate selection significantly influences conductive hydrogel behavior, affecting cell viability and proliferation as a result. In particular, the ITO substrates were found to provide the best support for cell viability with an average of at least three times higher metabolic activity compared to platinum and gold mylar substrates over a 7 day stimulation period. The study offers new insights into substrate selection as a platform for neural cell stimulation and underscores the critical role of substrate materials in optimizing the efficacy of neural interfaces for biomedical applications. In addition to extending existing work, this study provides a robust platform for future explorations aimed at tailoring the full potential of tissue-engineered neural interfaces.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.4c00111","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T11:32:25Z","timestamp":1715254345000},"page":"3775-3791","source":"Crossref","is-referenced-by-count":8,"title":["Wired for\nSuccess: Probing the Effect of Tissue-Engineered\nNeural Interface Substrates on Cell Viability"],"prefix":"10.1021","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-4197","authenticated-orcid":true,"given":"Adriana\nTeixeira do","family":"Nascimento","sequence":"first","affiliation":[{"name":"Swinburne University of Technology , , , ,","place":["Melbourne, Victoria, Australia, 3122"]},{"name":"St Vincent\u2019s Hospital Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6137-8320","authenticated-orcid":true,"given":"Alexandre X.","family":"Mendes","sequence":"additional","affiliation":[{"name":"Swinburne University of Technology , , , ,","place":["Melbourne, Victoria, Australia, 3122"]},{"name":"St Vincent\u2019s Hospital Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Duchi","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Hospital Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3065"]},{"name":"University of Melbourne, St Vincent\u2019s Hospital , , , ,","place":["Melbourne, Victoria, Australia, 3065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Duc","sequence":"additional","affiliation":[{"name":"Cardiff University , , ,","place":["Cardiff, United Kingdom, CF10 3NB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilith C.","family":"Aguilar","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Hospital Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3065"]},{"name":"The University of Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3010"]},{"name":"The University of Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4060-2079","authenticated-orcid":true,"given":"Anita F.","family":"Quigley","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Hospital Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3065"]},{"name":"RMIT University , , , ,","place":["Melbourne, Victoria, Australia, 3001"]},{"name":"St Vincent\u2019s Hospital Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M. I.","family":"Kapsa","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Hospital Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3065"]},{"name":"RMIT University , , , ,","place":["Melbourne, Victoria, Australia, 3001"]},{"name":"St Vincent\u2019s Hospital Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-0769","authenticated-orcid":true,"given":"David R.","family":"Nisbet","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Hospital Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3065"]},{"name":"The University of Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3010"]},{"name":"The University of Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3010"]},{"name":"The University of Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4882-9400","authenticated-orcid":true,"given":"Paul R.","family":"Stoddart","sequence":"additional","affiliation":[{"name":"Swinburne University of Technology , , , ,","place":["Hawthorn, Victoria, Australia, 3122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6119-4417","authenticated-orcid":true,"given":"Saimon M.","family":"Silva","sequence":"additional","affiliation":[{"name":"La Trobe University , , , ,","place":["Melbourne, Victoria, Australia, 3086"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8320-3852","authenticated-orcid":true,"given":"Simon E.","family":"Moulton","sequence":"additional","affiliation":[{"name":"Swinburne University of Technology , , , ,","place":["Melbourne, Victoria, Australia, 3122"]},{"name":"St Vincent\u2019s Hospital Melbourne , , , ,","place":["Melbourne, Victoria, Australia, 3065"]},{"name":"Swinburne University of Technology , , , ,","place":["Melbourne, Victoria, Australia, 3122"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"2026081411104671700_cit1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev.neuro.051508.135241","article-title":"The science of neural interface systems","volume":"32","author":"Hatsopoulos","year":"2009","journal-title":"Annu. 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