{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:45:05Z","timestamp":1791582305037,"version":"4.3.4"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62141109"],"award-info":[{"award-number":["62141109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62227803"],"award-info":[{"award-number":["62227803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Social Development Project of Jiangsu Province","award":["BE2022812"],"award-info":[{"award-number":["BE2022812"]}]},{"name":"Preface Leading Technical Basic Research Special Project of Jiangsu Province","award":["BK20212012"],"award-info":[{"award-number":["BK20212012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Biomater. Sci. Eng."],"published-print":{"date-parts":[[2024,7,8]]},"DOI":"10.1021\/acsbiomaterials.4c00390","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T05:10:57Z","timestamp":1717650657000},"page":"4347-4358","source":"Crossref","is-referenced-by-count":9,"title":["Carrier-Free Self-Assembled Nanomedicines for Promoting Apoptosis and Inhibiting Proliferation in Hepatocellular Carcinoma"],"prefix":"10.1021","volume":"10","author":[{"given":"WeiLu","family":"Jia","sequence":"first","affiliation":[{"name":"Medical School, Southeast University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenNing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenJing","family":"Xu","sequence":"additional","affiliation":[{"name":"Medical School, Southeast University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-3833","authenticated-orcid":true,"given":"YeWei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.10.037"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znab376"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15052"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01200-4"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00961-3"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00620"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.07.031"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5693"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.040"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.210"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/ph16010042"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-39"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2543"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn1725"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00547-x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00486-7"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22869"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1506"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0216-7"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2018.28"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6526"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2637"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.22061"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/ph15101199"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2019.04.004"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16723"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00950-z"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.006"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0410-2"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01310-2"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00618K"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00663"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.06.032"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00056J"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.05.071"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.03.020"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b21968"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119580"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800049"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202302985"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303831"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301784"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301352"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/am502541g"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.122075"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.8b01511"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.123169"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/ja105059g"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b02416"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.215672"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.0c02521"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00779"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.7150\/thno.30640"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22384"}],"container-title":["ACS Biomaterials Science & Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.4c00390","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.4c00390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T04:11:13Z","timestamp":1720411873000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsbiomaterials.4c00390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7,8]]}},"alternative-id":["10.1021\/acsbiomaterials.4c00390"],"URL":"https:\/\/doi.org\/10.1021\/acsbiomaterials.4c00390","relation":{},"ISSN":["2373-9878","2373-9878"],"issn-type":[{"value":"2373-9878","type":"print"},{"value":"2373-9878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,6]]}}}