{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:38:22Z","timestamp":1790116702546,"version":"4.0.1"},"reference-count":78,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271365"],"award-info":[{"award-number":["32271365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Project of Sichuan province","award":["2023YFS0151"],"award-info":[{"award-number":["2023YFS0151"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Biomater. Sci. Eng."],"published-print":{"date-parts":[[2024,7,8]]},"DOI":"10.1021\/acsbiomaterials.4c00680","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T19:23:57Z","timestamp":1718133837000},"page":"4496-4509","source":"Crossref","is-referenced-by-count":3,"title":["Three-Dimensional Mechanical Microenvironment Rescued the Decline of Osteogenic Differentiation of Old Human Jaw Bone Marrow Mesenchymal Stem Cells"],"prefix":"10.1021","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7088-0101","authenticated-orcid":true,"given":"Cheng","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"},{"name":"Hospital of Stomatology & Guangdong Provincial Key Laboratory of Stomatology & Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"},{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Orthodontics, College of Stomatology, Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Orthodontics, College of Stomatology, Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Orthodontics, College of Stomatology, Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"},{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Department of Orthodontics, College of Stomatology, Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-020-00680-9"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001291"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4839"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.591796"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3182801333"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-235585"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00435.x"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.05.012"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.04.010"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.830722"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10592"},{"issue":"6","key":"ref12\/cit12","first-page":"3398","volume":"11","author":"Wu Y.","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1007\/s40778-021-00186-6"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1111\/ger.12362"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-020-03732-x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2020.05.011"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.2174\/1574893615999200508091615"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.776984"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01267-2"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1515\/bmc-2021-0015"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02400-y"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1309-7"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-2753"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58060767"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-017-0886-8"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00107.2014"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt096"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366-6999.20123137"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m110.101147"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2352"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-185132"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0279-5"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.430"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.128040"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3444"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179323"},{"issue":"2","key":"ref37\/cit37","first-page":"120","volume":"31","author":"Tang Z. L.","year":"2022","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-7-14"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2005.10.001"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.802789"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.07.175"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.3.c810"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160x-2-8"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9290(03)00237-9"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3892\/br.2013.84"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.934"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/189516"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-017-0437-z"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1107\/S2052252521005054"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2022.3170892"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9050193"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005274"},{"issue":"7","key":"ref53\/cit53","first-page":"2976","volume":"35","author":"Sebag J.","year":"1994","journal-title":"Invest. Opthalmology Visual Sci."},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28916"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.356717"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.982278"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf0466"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2019.2275"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00223"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3892\/br.2016.779"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-022-03315-x"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10872"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07136-3"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.159"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-019-0223-1"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01684-z"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119396"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.023"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100434"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03939-7"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4383"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108177"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2015.0282"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103271"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100728"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03152-y"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-3724"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.788969"}],"container-title":["ACS Biomaterials Science & Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.4c00680","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.4c00680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T08:11:46Z","timestamp":1720426306000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsbiomaterials.4c00680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":78,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7,8]]}},"alternative-id":["10.1021\/acsbiomaterials.4c00680"],"URL":"https:\/\/doi.org\/10.1021\/acsbiomaterials.4c00680","relation":{},"ISSN":["2373-9878","2373-9878"],"issn-type":[{"value":"2373-9878","type":"print"},{"value":"2373-9878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,11]]}}}