{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:13:43Z","timestamp":1793308423667,"version":"4.5.0"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB027705"],"award-info":[{"award-number":["R01 EB027705"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CMMI 1846962"],"award-info":[{"award-number":["CMMI 1846962"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR 1847843"],"award-info":[{"award-number":["DMR 1847843"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Biomater. Sci. Eng."],"published-print":{"date-parts":[[2025,6,9]]},"DOI":"10.1021\/acsbiomaterials.4c02401","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T14:50:52Z","timestamp":1748443852000},"page":"3416-3431","source":"Crossref","is-referenced-by-count":7,"title":["Engineering Mechanical Microenvironments: Integration of Substrate and Flow Mechanics Reveals the Impact on the Endothelial Glycocalyx"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-7887","authenticated-orcid":true,"given":"Mohammad","family":"Hamrangsekachaee","sequence":"first","affiliation":[{"name":"Chemical Engineering Department","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5727-1256","authenticated-orcid":true,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Chemical Engineering Department","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6152-3843","authenticated-orcid":true,"given":"Emily R.","family":"Tressler","sequence":"additional","affiliation":[{"name":"Bioengineering Department","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3062-9934","authenticated-orcid":true,"given":"Lucas","family":"McCauley","sequence":"additional","affiliation":[{"name":"Bioengineering Department","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4037-2646","authenticated-orcid":true,"given":"Nicholas R.","family":"O\u2019Hare","sequence":"additional","affiliation":[{"name":"Chemical Engineering Department","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2877-4637","authenticated-orcid":true,"given":"Chinedu C.","family":"Okorafor","sequence":"additional","affiliation":[{"name":"Chemical Engineering Department","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7704-5608","authenticated-orcid":true,"given":"Sidi A.","family":"Bencherif","sequence":"additional","affiliation":[{"name":"Chemical Engineering Department","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]},{"name":"Bioengineering Department","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]},{"name":"Polymers, Biopolymers, Surfaces Laboratory (PBS, UMR CNRS 6270)","place":["Rouen, France"]},{"name":"University of Rouen Normandy","place":["Rouen, France"]},{"name":"Harvard John A. Paulson School of Engineering and Applied Sciences","place":["Cambridge, United States"]},{"name":"Harvard University","place":["Cambridge, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9483-1443","authenticated-orcid":true,"given":"Eno E.","family":"Ebong","sequence":"additional","affiliation":[{"name":"Chemical Engineering Department","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]},{"name":"Bioengineering Department","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]},{"name":"Neuroscience Department","place":["New York, United States"]},{"name":"Albert Einstein College of Medicine","place":["New York, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001209"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2010.123"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063346"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.542567"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312580"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c210029"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.711003"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00449.2022"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-020-00487-7"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1371769"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.731666"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1250348"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115635"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.317058"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.230854"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.04.210"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad076"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.76.4.536"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-020-02474-4"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901920R"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/s41231-018-0029-9"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1039\/D0LC00464B"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2612-2"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1055"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201400278"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3791\/67081"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/D2LC00657J"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/nature10137"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa201"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(03)00010-6"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-018-2000-3"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.038"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.230425"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.02.019"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046889"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2011.11.013"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304180"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02285-w"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1063\/1.3608137"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1063\/1.5143391"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63209-9"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctm.2018.09.003"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.07.042"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7943"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31037"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.008"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1721-2"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200205001-00024"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.057"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314935"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00117.2002"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0555"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.45.29965"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06517.x"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwaa008"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1375"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.073106"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00097.2007"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.449"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-188375"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2010.06.001"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.164707"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000115703.30835.96"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.07.022"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.972653"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000259362.10882.c5"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12455"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.165753"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.03.020"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63414-1"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.042"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.3390\/cells8040295"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23479"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.7150\/thno.35665"}],"container-title":["ACS Biomaterials Science & Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.4c02401","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.4c02401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T08:10:20Z","timestamp":1749456620000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsbiomaterials.4c02401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":74,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,9]]}},"alternative-id":["10.1021\/acsbiomaterials.4c02401"],"URL":"https:\/\/doi.org\/10.1021\/acsbiomaterials.4c02401","relation":{},"ISSN":["2373-9878","2373-9878"],"issn-type":[{"value":"2373-9878","type":"print"},{"value":"2373-9878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]}}}