{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:02:02Z","timestamp":1792173722335,"version":"4.4.0"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Xijing Hospital","award":["LHJJ24HL06"],"award-info":[{"award-number":["LHJJ24HL06"]}]},{"name":"Xijing Hospital","award":["XJZT24LY06"],"award-info":[{"award-number":["XJZT24LY06"]}]},{"name":"Xijing Hospital","award":["XJZT25JS02"],"award-info":[{"award-number":["XJZT25JS02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Biomater. Sci. Eng."],"published-print":{"date-parts":[[2025,12,8]]},"DOI":"10.1021\/acsbiomaterials.5c01079","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:11:22Z","timestamp":1761930682000},"page":"7357-7367","source":"Crossref","is-referenced-by-count":5,"title":["Low-Temperature Three-Dimensional Bioprinted Dual-Factor rhBMP-2\/VEGF-165 Biomimetic Scaffolds for Synergistic Bone-Vascularization Repair in Large Segmental Bone Defect"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-1906","authenticated-orcid":true,"given":"Jiahao","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Orthopedics","place":["Xi\u2019an, China"]},{"name":"The First Affiliated Hospital (Xijing Hospital), Air Force Medical University","place":["Xi\u2019an, China"]},{"name":"Sixth Department","place":["Xingcheng, China"]},{"name":"Joint Logistics Support Force Xingcheng Special Duty Sanatorium of PLA","place":["Xingcheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Xi\u2019an, China"]},{"name":"The First Affiliated Hospital (Xijing Hospital), Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Xi\u2019an, China"]},{"name":"The First Affiliated Hospital (Xijing Hospital), Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyou","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Xi\u2019an, China"]},{"name":"The First Affiliated Hospital (Xijing Hospital), Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Xi\u2019an, China"]},{"name":"The First Affiliated Hospital (Xijing Hospital), Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Orthopedic Research Institute","place":["Xi\u2019an, China"]},{"name":"The First Affiliated Hospital (Xijing Hospital), Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Xi\u2019an, China"]},{"name":"The First Affiliated Hospital (Xijing Hospital), Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Xi\u2019an, China"]},{"name":"The First Affiliated Hospital (Xijing Hospital), Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Xi\u2019an, China"]},{"name":"The First Affiliated Hospital (Xijing Hospital), Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Orthopedic Research Institute","place":["Xi\u2019an, China"]},{"name":"The First Affiliated Hospital (Xijing Hospital), Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-1690","authenticated-orcid":true,"given":"Junjun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Xi\u2019an, China"]},{"name":"The First Affiliated Hospital (Xijing Hospital), Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2021.01.043"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200100022-00007"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202403641"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbad046"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00992-4"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120995"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c11890"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201096"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.05.007"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.09.014"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217214"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.4161\/cam.2.1.5884"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.04.027"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-00024-z"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.01.004"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100681"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213959"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/jfb15060145"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101015"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.141440"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152324099"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82585"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021899"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111480"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123330"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(03)00193-2"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-016-0352-8"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c00246"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123352"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb5093"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nature13145"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.03.012"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2020.05.005"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-023-00288-1"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110893"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2015.03.068"}],"container-title":["ACS Biomaterials Science & Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.5c01079","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.5c01079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T09:11:48Z","timestamp":1765185108000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsbiomaterials.5c01079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,8]]}},"alternative-id":["10.1021\/acsbiomaterials.5c01079"],"URL":"https:\/\/doi.org\/10.1021\/acsbiomaterials.5c01079","relation":{},"ISSN":["2373-9878","2373-9878"],"issn-type":[{"value":"2373-9878","type":"print"},{"value":"2373-9878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]}}}