{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:13:46Z","timestamp":1793114026360,"version":"4.5.0"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R15CA252987"],"award-info":[{"award-number":["R15CA252987"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Glioblastoma is a highly aggressive brain tumor whose treatment has improved little over the past decade. We report on the synergistic effect of the FDA-approved anti-GBM drug (temozolomide) and inhibitors (acriflavine, PT2385) of hypoxia-inducible factors (HIFs) embedded into coaxial fiber membranes (NanoMesh). In vitro cytotoxicity has been evaluated for various glioma cell lines, and synergistic drug combinations have been identified. Preliminary animal studies with the three-drug-loaded NanoMesh indicate a significant improvement of median survival of &amp;gt;50 days and long-term (&amp;gt;120 days) survival rate of 40%, indicating the potential of this material platform as a translatable local GBM therapy.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.5c01482","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:10:14Z","timestamp":1778771414000},"page":"3312-3318","source":"Crossref","is-referenced-by-count":1,"title":["Codelivery Material System of Polymer Microfiber Structures for Synergistic Localized Therapy of Glioblastoma"],"prefix":"10.1021","volume":"12","author":[{"given":"Daewoo","family":"Han","sequence":"first","affiliation":[{"name":"University of Cincinnati , , , ,","place":["Cincinnati, Ohio, United States, 45221"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4597-3642","authenticated-orcid":true,"given":"Hasan","family":"Slika","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21287"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanya","family":"Shahani","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21287"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana S.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21287"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles G.","family":"Eberhart","sequence":"additional","affiliation":[{"name":"School of Medicine, Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21205"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Brem","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21287"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21287"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9800-6969","authenticated-orcid":true,"given":"Betty","family":"Tyler","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21287"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1868-4442","authenticated-orcid":true,"given":"Andrew J.","family":"Steckl","sequence":"additional","affiliation":[{"name":"University of Cincinnati , , , ,","place":["Cincinnati, Ohio, United States, 45221"]},{"name":"University of Cincinnati , , , ,","place":["Cincinnati, Ohio, United States, 45221"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"issue":"5","key":"2026101319065341400_cit1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"Stupp","year":"2009","journal-title":"Lancet Oncol."},{"issue":"10","key":"2026101319065341400_cit2","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. 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