{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:00:56Z","timestamp":1789614056674,"version":"build-2803163510"},"reference-count":61,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172485"],"award-info":[{"award-number":["82172485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372457"],"award-info":[{"award-number":["82372457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Orthopedic Medical Innovation Center of Jiangsu","award":["CXZX202209"],"award-info":[{"award-number":["CXZX202209"]}]},{"name":"Key Laboratory of Orthopedics of Suzhou","award":["SZS2022017"],"award-info":[{"award-number":["SZS2022017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Biomater. Sci. Eng."],"published-print":{"date-parts":[[2026,3,9]]},"DOI":"10.1021\/acsbiomaterials.5c01910","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T08:20:12Z","timestamp":1772007612000},"page":"1732-1748","source":"Crossref","is-referenced-by-count":4,"title":["An Apigenin-Based Bone-Targeted System Enhances Antioxidant Capacity of Bone Marrow Mesenchymal Stem Cells via the PI3K\/Akt Pathway to Alleviate Osteoporosis"],"prefix":"10.1021","volume":"12","author":[{"given":"Daihui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, 899 Pinghai Road, Suzhou 215031, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, 899 Pinghai Road, Suzhou 215031, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, 899 Pinghai Road, Suzhou 215031, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, 899 Pinghai Road, Suzhou 215031, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, 899 Pinghai Road, Suzhou 215031, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjia","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Health Management Center","place":["Suzhou, China"]},{"name":"The First Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6048-9247","authenticated-orcid":true,"given":"Xu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, 899 Pinghai Road, Suzhou 215031, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-752X","authenticated-orcid":true,"given":"Qin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, 899 Pinghai Road, Suzhou 215031, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32112-3"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.7326\/AITC202401160"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02646-5"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/med.21476"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.95661"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.01.024"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-024-01039-y"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.fmre.2024.02.002"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043772"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114834"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.02.025"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101450"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113390"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa214"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12970"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156519"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1221227"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmt.2023.06.002"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbaf004"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.20517\/2347-9264.2025.09"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.07.002"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e09394"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.873125"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03544-2"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/0169-6009(91)90124-I"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123326"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-019-1555-9"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2030818"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.09.020"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.007"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.12.126004"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.01.033"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202413238"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703610104"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2019.1658376"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/procel\/pwae008"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-024-00689-6"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.657"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31323"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2025.100576"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1007\/s40203-023-00170-4"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12061353"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.657953"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2014.121"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2015.04.010"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1080\/10715760801993076"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-025-01722-w"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.19708"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2023.10.002"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12111123"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2010.06.088"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218224"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.873125"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10070781"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c12213"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-024-00425-4"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1361864"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1007\/s42765-024-00475-9"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2024.03.013"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbae007"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.34133\/research.0581"}],"container-title":["ACS Biomaterials Science & Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.5c01910","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.5c01910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:38:58Z","timestamp":1773128338000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsbiomaterials.5c01910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,9]]}},"alternative-id":["10.1021\/acsbiomaterials.5c01910"],"URL":"https:\/\/doi.org\/10.1021\/acsbiomaterials.5c01910","relation":{},"ISSN":["2373-9878","2373-9878"],"issn-type":[{"value":"2373-9878","type":"print"},{"value":"2373-9878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]}}}