{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:49:20Z","timestamp":1791967760152,"version":"4.3.4"},"reference-count":75,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr?d","doi-asserted-by":"publisher","award":["331752"],"award-info":[{"award-number":["331752"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr?d","doi-asserted-by":"publisher","award":["332148"],"award-info":[{"award-number":["332148"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr?d","doi-asserted-by":"publisher","award":["346292"],"award-info":[{"award-number":["346292"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr?d","doi-asserted-by":"publisher","award":["359679"],"award-info":[{"award-number":["359679"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Effective decontamination of dental implants is essential for managing peri-implant diseases, yet its impact on the salivary pellicle and cell response remains unclear. As the pellicle mediates bacterial and host cell interactions, investigating how decontamination alters its composition is key to understanding the effects on biological outcomes. Accordingly, we examined how a Poloxamer 407 (P407) hydrogel, a P407 + hydrogen peroxide (H2O2) hydrogel, a titanium brush, and their combinations influence the adsorbed salivary proteins and cell adhesion on OsseoSpeed-like titanium surfaces. Surfaces with salivary proteins were treated with different decontamination methods and re-exposed to saliva. Protein quantity was measured using the BCA assay, while the proteomic composition and molecular functions of the adsorbed proteins were determined by liquid chromatography-mass spectrometry and gene ontology analysis. Human bone marrow mesenchymal stem cell (hBMMSC) adhesion was assessed on the surfaces, and cytotoxicity was evaluated using an LDH assay. Protein-coated and protein-free surfaces served as controls. Although protein levels were consistent across groups after either decontamination or recontamination, each treatment produced a different proteomic profile. Mechanical decontamination, alone or combined with chemicals, enhanced protein removal efficiency. Combined treatments yielded reduced protein diversity following recontamination and enriched adhesion-related proteins. None of the treatments compromised hBMMSC adhesion nor made the surface cytotoxic. Decontamination methods selectively modify the proteomic profile. Combined chemical and mechanical decontamination promotes the removal of salivary proteins and limits their readsorption while preserving cytocompatibility, supporting their relevance to peri-implant health.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.5c01973","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T19:49:09Z","timestamp":1779997749000},"page":"3403-3415","source":"Crossref","is-referenced-by-count":0,"title":["Combined Chemical and Mechanical Debridement Enhances Salivary Protein Removal from Titanium while Maintaining Biological Properties"],"prefix":"10.1021","volume":"12","author":[{"given":"Angela","family":"De Lauretis","sequence":"first","affiliation":[{"name":"University of Oslo , , ,","place":["Oslo, Norway, 0455"]},{"name":"Corticalis AS , Oslo Science Park, Gaustadall\u00e9en 21 , ,","place":["Oslo, Norway, 0349"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Santacroce","sequence":"additional","affiliation":[{"name":"University of Oslo , , ,","place":["Oslo, Norway, 0455"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Oslo , , ,","place":["Oslo, Norway, 0455"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ramirez Garrastacho","sequence":"additional","affiliation":[{"name":"University of Oslo , , ,","place":["Oslo, Norway, 0316"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianli","family":"Ma","sequence":"additional","affiliation":[{"name":"University of Oslo , , ,","place":["Oslo, Norway, 0455"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e5le Petter","family":"Lyngstadaas","sequence":"additional","affiliation":[{"name":"University of Oslo , , ,","place":["Oslo, Norway, 0455"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Eirik","family":"Ellingsen","sequence":"additional","affiliation":[{"name":"University of Oslo , , ,","place":["Oslo, Norway, 0455"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Linke","sequence":"additional","affiliation":[{"name":"University of Oslo , , ,","place":["Oslo, Norway, 0316"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5vard Jostein","family":"Haugen","sequence":"additional","affiliation":[{"name":"University of Oslo , , ,","place":["Oslo, Norway, 0455"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"2026101319070469800_cit1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jdent.2019.03.008","article-title":"Long-Term (10-Year) Dental Implant Survival: A Systematic Review and Sensitivity Meta-Analysis","volume":"84","author":"Howe","year":"2019","journal-title":"J. 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