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Unlike previous silver- and graphene-based materials, the GQD\/AgNP hybrids exhibit a high oxidase-like catalytic activity and possess favorable stability in neutral medium within the range from room temperature to 60 \u00b0C. In accordance with their prominent enzyme activities, the GQD\/AgNP hybrids show excellent antibacterial properties against Gram-negative and Gram-positive bacteria as well as drug resistant bacteria, with an ultralow minimal inhibitory concentration (2\u20134 \u03bcg\/mL) against 1 \u00d7 107 to 1 \u00d7 108 \u03bcg\/mL Escherichia coli and Staphylococcus aureus. In the presence of the GQD\/AgNP hybrids, the fluorescence behavior after the introduction of 2\u2032, 7\u2032-dichlorofluorescin diacetate demonstrated a possible role of reactive oxidative species in the GQD\/AgNP hybrid-mediated antibacterial therapeutic effect. Furthermore, TEM and SEM imaging identified concomitant disruption of the bacterial cell membrane and loss of barrier function during the sterilization process. Therefore, the GQD\/AgNP hybrids exhibit vast potentials for serving as highly effective, broad-spectrum antibacterial agent for sterilization use without the need of additional stimulation by laser irradiation (photosensitization) or the provision of H2O2, facilitating their relative ease of use and cost-effectiveness.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.6b00644","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T12:16:04Z","timestamp":1485260164000},"page":"313-321","source":"Crossref","is-referenced-by-count":159,"title":["Graphene Quantum Dot\/Silver Nanoparticle Hybrids with\nOxidase Activities for Antibacterial Application"],"prefix":"10.1021","volume":"3","author":[{"given":"Shuai","family":"Chen","sequence":"first","affiliation":[{"name":"Northeastern University , , No. 195, Chuangxin Road, Hunnan District , ,","place":["Shenyang, China, 110169"]},{"name":"Northeastern University , , No. 3-11, Wenhua Road, Heping District , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Quan","sequence":"additional","affiliation":[{"name":"Northeastern University , , No. 3-11, Wenhua Road, Heping District , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9763-0954","authenticated-orcid":true,"given":"Yong-Liang","family":"Yu","sequence":"additional","affiliation":[{"name":"Northeastern University , , No. 3-11, Wenhua Road, Heping District , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2175-3610","authenticated-orcid":true,"given":"Jian-Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Northeastern University , , No. 3-11, Wenhua Road, Heping District , ,","place":["Shenyang, China, 110819"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"issue":"38","key":"2026081500074434200_cit1","doi-asserted-by":"publisher","first-page":"4591","DOI":"10.1039\/c2cc17766h","article-title":"Photosensitizer\nand vancomycin-conjugated novel multifunctional magnetic particles\nas photoinactivation agents for selective killing of pathogenic bacteria","volume":"48","author":"Choi","year":"2012","journal-title":"Chem. 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