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The composition, hierarchical architecture, biomineralization mechanisms, and species-specific characteristics of MBMs collectively determine their physicochemical properties and regenerative potential. The porous framework of coral bone, the \u201cbrick-and-mortar\u201d structure of nacre, the multi-chambered design of cuttlebone, and the concentric lamellae of sponge spicules provide mechanical strength, facilitate vascularization, and support osteogenesis. Furthermore, bioactive proteins and ions inherent in MBMs further may promote osteoinduction and angiogenesis. Despite their potential, challenges related to resource sustainability, mechanical compatibility, and clinical scalability remain. By enhancing the functionality and applicability of MBMs, designing strategies for the preparation of emerging materials has become a major research highlight including 3D printing, biomimetic synthesis, and composite fabrication. MBMs represent a diverse class of biomineralized resources with significant application value in bone repair and regeneration. This review presents the transition of MBMs from passive bone grafts to active, intelligent regenerative systems, offering innovative solutions for the treatment of bone defects while aligning with ecological and economic sustainability.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.6c00447","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:01:58Z","timestamp":1790715718000},"page":"5125-5144","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Marine Biomineralized Materials in Bone Repair and Regeneration"],"prefix":"10.1021","volume":"12","author":[{"given":"Bixuan","family":"Cao","sequence":"first","affiliation":[{"name":"The Third Affiliated Hospital of Anhui Medical University, the First People\u2019s Hospital of Hefei , , ,","place":["Hefei, China, 230061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Guo","sequence":"additional","affiliation":[{"name":"Jining Medical University , , ,","place":["Rizhao, China, 276826"]},{"name":"Institute of Translational Medicine, Jining Medical University , ,","place":["Rizhao, China, 276826"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Cui","sequence":"additional","affiliation":[{"name":"Shenzhen University , , ,","place":["Shenzhen, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoyang","family":"Liang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Anhui Medical University, the First People\u2019s Hospital of Hefei , , ,","place":["Hefei, China, 230061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leisheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Fourth People's Hospital of Jinan Affiliated to Shandong Second Medical University , , ,","place":["Jinan, China, 250031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Ren","sequence":"additional","affiliation":[{"name":"Jining Medical University , , ,","place":["Rizhao, China, 276826"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wei","sequence":"additional","affiliation":[{"name":"Jining Medical University , , ,","place":["Jining, China, 272067"]},{"name":"Jining Medical University , , ,","place":["Jining, China, 272067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-263X","authenticated-orcid":true,"given":"Rende","family":"Ning","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Anhui Medical University, the First People\u2019s Hospital of Hefei , , ,","place":["Hefei, China, 230061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jining Medical University , , ,","place":["Jining, China, 272000"]},{"name":"Affiliated Hospital of Jining Medical University , , ,","place":["Jining, China, 272000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibao","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Jining Medical University , ,","place":["Rizhao, China, 276826"]},{"name":"Jining Medical University , , ,","place":["Rizhao, China, 276826"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3334-4838","authenticated-orcid":true,"given":"Mingzhi","family":"Song","sequence":"additional","affiliation":[{"name":"Jining Medical University , , ,","place":["Rizhao, China, 276826"]},{"name":"Institute of Translational Medicine, Jining Medical University , ,","place":["Rizhao, China, 276826"]},{"name":"Jining Medical University , , ,","place":["Jining, China, 272067"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"1","key":"2026101202065530100_cit1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s11160-021-09636-0","article-title":"Ocean Resource Use: Building the Coastal Blue Economy","volume":"32","author":"Bax","year":"2022","journal-title":"Rev. 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