{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:24:40Z","timestamp":1787005480274,"version":"build-2736575974"},"reference-count":191,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["17JCZDJC36000"],"award-info":[{"award-number":["17JCZDJC36000"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["18JCZDJC35900"],"award-info":[{"award-number":["18JCZDJC35900"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11102135"],"award-info":[{"award-number":["11102135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11372223"],"award-info":[{"award-number":["11372223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Key Medical Discipline Construction Project","award":["TJYXZDXK-3-002A-3"],"award-info":[{"award-number":["TJYXZDXK-3-002A-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stroke remains a leading global health problem, and effective neuroprotective and regenerative therapies are still limited. Although acute-phase reperfusion strategies have advanced, their narrow therapeutic windows and the risk of reperfusion injury highlight the urgent need for broader neuroprotective and regenerative approaches. Here, we review lipid-based nanocarriers as a drug delivery platform, with a particular focus on spatiotemporal drug delivery across distinct stroke phases (acute, subacute, and recovery). To date, no dedicated review has comprehensively summarized the spatiotemporal applications of lipid-based nanocarriers in stroke therapy. We discuss their potential for blood\u2013brain barrier (BBB) penetration, inflammation modulation, and neural regeneration. Despite these promising opportunities, substantial challenges remain, including standardized formulation and barriers to clinical translation. This review offers theoretical and practical guidance for future translational efforts, emphasizing chemical design of lipid-based carriers and its role in optimizing therapeutic efficacy.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.6c00712","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:17:29Z","timestamp":1785849449000},"page":"3985-4014","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporal Strategies for Lipid-Based Nanocarriers in Stroke"],"prefix":"10.1021","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4945-7727","authenticated-orcid":true,"given":"Miaomiao","family":"Xiao","sequence":"first","affiliation":[{"name":"Tianjin University of Sport , ,","place":["Tianjin, China, 301617"]},{"name":"Tianjin Sports Injury and Rehabilitation Virtual Simulation Teaching Center , ,","place":["Tianjin, China, 301617"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin University of Sport , ,","place":["Tianjin, China, 301617"]},{"name":"Tianjin Sports Injury and Rehabilitation Virtual Simulation Teaching Center , ,","place":["Tianjin, China, 301617"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1176-2705","authenticated-orcid":true,"given":"Qinghua","family":"Meng","sequence":"additional","affiliation":[{"name":"Tianjin University of Sport , ,","place":["Tianjin, China, 301617"]},{"name":"Tianjin Sports Injury and Rehabilitation Virtual Simulation Teaching Center , ,","place":["Tianjin, China, 301617"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Tianjin University of Sport , ,","place":["Tianjin, China, 301617"]},{"name":"Tianjin Sports Injury and Rehabilitation Virtual Simulation Teaching Center , ,","place":["Tianjin, China, 301617"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin University of Sport , ,","place":["Tianjin, China, 301617"]},{"name":"Tianjin Sports Injury and Rehabilitation Virtual Simulation Teaching Center , ,","place":["Tianjin, China, 301617"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuequan","family":"Feng","sequence":"additional","affiliation":[{"name":"Tianjin first Central Hospital , , ,","place":["Tianjin, China, 300384"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3329-9444","authenticated-orcid":true,"given":"Chunyu","family":"Bao","sequence":"additional","affiliation":[{"name":"Tianjin University of Sport , ,","place":["Tianjin, China, 301617"]},{"name":"Tianjin Sports Injury and Rehabilitation Virtual Simulation Teaching Center , ,","place":["Tianjin, China, 301617"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"issue":"1","key":"2026081717142037200_cit1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s12916-019-1397-3","article-title":"Socioeconomic status and stroke incidence, prevalence, mortality, and worldwide burden: an ecological analysis from the Global Burden of Disease Study 2017","volume":"17","author":"Avan","year":"2019","journal-title":"BMC Med."},{"issue":"12","key":"2026081717142037200_cit2","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/S1474-4422(23)00277-6","article-title":"Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization-Lancet Neurology Commission","volume":"22","author":"Feigin","year":"2023","journal-title":"Lancet Neurol."},{"issue":"14","key":"2026081717142037200_cit3","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/eurheartj\/ehac684","article-title":"Acute ischaemic stroke: recent advances in reperfusion treatment","volume":"44","author":"Widimsky","year":"2023","journal-title":"Eur. Heart J."},{"issue":"11","key":"2026081717142037200_cit4","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1212\/WNL.55.11.1649","article-title":"Early stroke treatment associated with better outcome: the NINDS rt-PA stroke study","volume":"55","author":"Marler","year":"2000","journal-title":"Neurology"},{"issue":"9834","key":"2026081717142037200_cit5","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1016\/S0140-6736(12)60822-8","article-title":"rt-PA for ischaemic stroke: what will the next question be?","volume":"379","author":"Leys","year":"2012","journal-title":"Lancet"},{"issue":"1","key":"2026081717142037200_cit6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"2026081717142037200_cit7","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s13578-023-01126-z","article-title":"Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke","volume":"13","author":"Gao","year":"2023","journal-title":"Cell Biosci."},{"issue":"7","key":"2026081717142037200_cit8","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.4103\/NRR.NRR-D-24-00392","article-title":"Beyond wrecking a wall: revisiting the concept of blood-brain barrier breakdown in ischemic stroke","volume":"20","author":"Castillo-Gonz\u00e1lez","year":"2025","journal-title":"Neural Regen. Res."},{"key":"2026081717142037200_cit9","doi-asserted-by":"publisher","first-page":"5381","DOI":"10.2147\/IJN.S117210","article-title":"Getting into the brain: liposome-based strategies for effective drug delivery across the blood-brain barrier","volume":"11","author":"Vieira","year":"2016","journal-title":"Int. J. Nanomed."},{"issue":"12","key":"2026081717142037200_cit10","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1001\/jamaneurol.2020.3362","article-title":"Trends in Reperfusion Therapy for In-Hospital Ischemic Stroke in the Endovascular Therapy Era","volume":"77","author":"Akbik","year":"2020","journal-title":"JAMA Neurol."},{"issue":"1","key":"2026081717142037200_cit11","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1161\/STROKEAHA.123.043764","article-title":"CNS Drug Delivery in Stroke: Improving Therapeutic Translation From the Bench to the Bedside","volume":"55","author":"Ronaldson","year":"2024","journal-title":"Stroke"},{"key":"2026081717142037200_cit12","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/S0140-6736(24)01410-7","article-title":"Endovascular management of acute stroke","author":"Nguyen","year":"2024","journal-title":"Lancet"},{"issue":"2","key":"2026081717142037200_cit13","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1177\/17474930241308142","article-title":"World Stroke Organization: Global Stroke Fact Sheet 2025","volume":"20","author":"Feigin","year":"2025","journal-title":"Int. J. Stroke"},{"issue":"6","key":"2026081717142037200_cit14","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1161\/CIRCRESAHA.124.323508","article-title":"Stroke in the Time of Circadian Medicine","volume":"134","author":"Mergenthaler","year":"2024","journal-title":"Circ. Res."},{"key":"2026081717142037200_cit15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jconrel.2024.06.005","article-title":"PEG length effect of peptide-functional liposome for blood brain barrier (BBB) penetration and brain targeting","volume":"372","author":"Du","year":"2024","journal-title":"J. Control. Release"},{"key":"2026081717142037200_cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2026.108825","article-title":"Circadian rhythms in ischemic stroke: From pathogenesis to chronotherapy","volume":"141","author":"Fan","year":"2026","journal-title":"Sleep Med."},{"issue":"5","key":"2026081717142037200_cit17","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1161\/STROKEAHA.118.022744","article-title":"Recent Advances in Nanomedicine for Ischemic and Hemorrhagic Stroke","volume":"50","author":"Bonnard","year":"2019","journal-title":"Stroke"},{"issue":"2","key":"2026081717142037200_cit18","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.drudis.2020.11.018","article-title":"Nanotechnology in the diagnosis and treatment of stroke","volume":"26","author":"Sarmah","year":"2021","journal-title":"Drug Discov. Today"},{"key":"2026081717142037200_cit19","doi-asserted-by":"publisher","first-page":"3715","DOI":"10.2147\/IJN.S462194","article-title":"Innovations in Breaking Barriers: Liposomes as Near-Perfect Drug Carriers in Ischemic Stroke Therapy","volume":"19","author":"Zhang","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"2026081717142037200_cit20","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.brainresbull.2019.07.015","article-title":"Liposomes for drug delivery in stroke","volume":"152","author":"Bruch","year":"2019","journal-title":"Brain Res. Bull."},{"issue":"1","key":"2026081717142037200_cit21","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jconrel.2012.02.004","article-title":"Amelioration of cerebral ischemia-reperfusion injury based on liposomal drug delivery system with asialo-erythropoietin","volume":"160","author":"Ishii","year":"2012","journal-title":"J. Control. Release"},{"issue":"5","key":"2026081717142037200_cit22","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.4103\/NRR.NRR-D-24-01383","article-title":"Drug delivery strategies for neuroprotective therapy in ischemic stroke: Application of nanotechnology","volume":"21","author":"Jiang","year":"2026","journal-title":"Neural Regen. Res."},{"issue":"17","key":"2026081717142037200_cit23","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.2174\/1381612824666180515123543","article-title":"Chitosan-coated C-phycocyanin Liposome for Extending the Neuroprotective Time Window Against Ischemic Brain Stroke","volume":"24","author":"Chung","year":"2018","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"2026081717142037200_cit24","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/s12035-024-04215-3","article-title":"Revolutionizing Stroke Care: Nanotechnology-Based Brain Delivery as a Novel Paradigm for Treatment and Diagnosis","volume":"62","author":"Balaji","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"1-3","key":"2026081717142037200_cit25","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0009-3084(93)90071-A","article-title":"Liposomes: the Babraham connection","volume":"64","author":"Bangham","year":"1993","journal-title":"Chem. Phys. Lipids"},{"key":"2026081717142037200_cit26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2022.02.017","article-title":"Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms","volume":"182","author":"Guo","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"2026081717142037200_cit27","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S0031-6997(24)01426-1","article-title":"Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors","volume":"51","author":"Drummond","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"2026081717142037200_cit28","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.2147\/IJN.S193965","article-title":"Intraperitoneal delivery of acetate-encapsulated liposomal nanoparticles for neuroprotection of the penumbra in a rat model of ischemic stroke","volume":"14","author":"So","year":"2019","journal-title":"Int. J. Nanomedicine"},{"issue":"11","key":"2026081717142037200_cit29","doi-asserted-by":"publisher","first-page":"4930","DOI":"10.1021\/acsbiomaterials.2c00847","article-title":"Ligustrazine-Loaded Borneol Liposome Alleviates Cerebral Ischemia-Reperfusion Injury in Rats","volume":"8","author":"Wen","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"2","key":"2026081717142037200_cit30","doi-asserted-by":"publisher","first-page":"689","DOI":"10.7150\/thno.64806","article-title":"Dodging blood brain barrier with \"nano\" warriors: Novel strategy against ischemic stroke","volume":"12","author":"Parvez","year":"2022","journal-title":"Theranostics"},{"key":"2026081717142037200_cit31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2018.05.082","article-title":"Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism","volume":"124","author":"Zhao","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"2026081717142037200_cit32","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.1014208","article-title":"OEA loaded liposomes with the neuroprotective effect for stroke therapy","volume":"10","author":"Wu","year":"2022","journal-title":"Front. Chem."},{"key":"2026081717142037200_cit33","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.2147\/IJN.S107292","article-title":"Charge effect of a liposomal delivery system encapsulating simvastatin to treat experimental ischemic stroke in rats","volume":"11","author":"Campos-Martorell","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"2026081717142037200_cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2022.103155","article-title":"Effect of phospholipids on membrane characteristics and storage stability of liposomes","volume":"81","author":"Song","year":"2022","journal-title":"Innov. Food Sci. Emerg. Technol."},{"issue":"30","key":"2026081717142037200_cit35","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1016\/j.biomaterials.2008.07.008","article-title":"The role of daidzein-loaded sterically stabilized solid lipid nanoparticles in therapy for cardio-cerebrovascular diseases","volume":"29","author":"Gao","year":"2008","journal-title":"Biomaterials"},{"key":"2026081717142037200_cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105699","article-title":"Microfluidic development of brain-derived neurotrophic factor loaded solid lipid nanoparticles: An in vitro evaluation in the post-traumatic brain injury neuroinflammation model","volume":"96","author":"Sommonte","year":"2024","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"2026081717142037200_cit37","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.jconrel.2017.08.033","article-title":"Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases","volume":"264","author":"Tapeinos","year":"2017","journal-title":"J. Control. Release"},{"key":"2026081717142037200_cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2022.102543","article-title":"In vitro and in vivo implications of rationally designed bromelain laden core-shell hybrid solid lipid nanoparticles for oral administration in thrombosis management","volume":"42","author":"Sharma","year":"2022","journal-title":"Nanomedicine"},{"issue":"10","key":"2026081717142037200_cit39","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1016\/S0142-9612(02)00578-1","article-title":"The production and characteristics of solid lipid nanoparticles (SLNs)","volume":"24","author":"Hou","year":"2003","journal-title":"Biomaterials"},{"issue":"45","key":"2026081717142037200_cit40","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201903156","article-title":"On the structure of solid lipid nanoparticles","volume":"15","author":"Pink","year":"2019","journal-title":"Small"},{"key":"2026081717142037200_cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.113857","article-title":"Curcumin\/TGF-\u03b21 siRNA loaded solid lipid nanoparticles alleviate cerebral injury after intracerebral hemorrhage by transnasal brain targeting","volume":"237","author":"Abudurexiti","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"11","key":"2026081717142037200_cit42","doi-asserted-by":"publisher","first-page":"16982","DOI":"10.1021\/acsnano.1c04996","article-title":"Lipid Nanoparticles\u2500From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement","volume":"15","author":"Tenchov","year":"2021","journal-title":"ACS Nano"},{"issue":"1","key":"2026081717142037200_cit43","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1021\/acs.accounts.1c00544","article-title":"Chemistry of Lipid Nanoparticles for RNA Delivery","volume":"55","author":"Eygeris","year":"2022","journal-title":"Acc. Chem. Res."},{"issue":"4","key":"2026081717142037200_cit44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002105","article-title":"Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles","volume":"21","author":"Hamilton","year":"2023","journal-title":"PLoS Biol."},{"key":"2026081717142037200_cit45","doi-asserted-by":"publisher","DOI":"10.26599\/NR.2025.94907836","article-title":"Functional nanomaterial strategies for targeted CNS drug delivery","volume":"18","author":"Ye","year":"2025","journal-title":"Nano Res."},{"key":"2026081717142037200_cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113879","article-title":"A perspective on the apparent pKa of ionizable lipids in mRNA-LNPs","volume":"384","author":"Simonsen","year":"2025","journal-title":"J. Control. Release"},{"issue":"47","key":"2026081717142037200_cit47","doi-asserted-by":"publisher","first-page":"40293","DOI":"10.1021\/acsnano.5c11721","article-title":"Endosomal Escape of Lipid Nanoparticles: A Perspective on the Literature Data","volume":"19","author":"Pei","year":"2025","journal-title":"ACS Nano"},{"issue":"4","key":"2026081717142037200_cit48","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305300","article-title":"Lipid Nanoparticles Optimized for Targeting and Release of Nucleic Acid","volume":"36","author":"Jia","year":"2024","journal-title":"Adv. Mater."},{"issue":"11","key":"2026081717142037200_cit49","doi-asserted-by":"publisher","first-page":"8971","DOI":"10.1021\/acsnano.5c21857","article-title":"Mechanistic and Strategic Insights into How Lipid Nanoparticles Interact with Membrane-Based Biological Barriers","volume":"20","author":"Zhao","year":"2026","journal-title":"ACS Nano"},{"issue":"1","key":"2026081717142037200_cit50","doi-asserted-by":"publisher","first-page":"3686","DOI":"10.1038\/s41467-019-11642-7","article-title":"Interplay of protein corona and immune cells controls blood residency of liposomes","volume":"10","author":"Giulimondi","year":"2019","journal-title":"Nat. Commun."},{"issue":"12","key":"2026081717142037200_cit51","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.3390\/pharmaceutics16121521","article-title":"Effect of Lipid Nanoparticle Physico-Chemical Properties and Composition on Their Interaction with the Immune System","volume":"16","author":"Catenacci","year":"2024","journal-title":"Pharmaceutics"},{"key":"2026081717142037200_cit52","doi-asserted-by":"publisher","first-page":"8103","DOI":"10.2147\/IJN.S344318","article-title":"Endogenous Oleoylethanolamide Crystals Loaded Lipid Nanoparticles with Enhanced Hydrophobic Drug Loading Capacity for Efficient Stroke Therapy","volume":"16","author":"Wu","year":"2021","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"2026081717142037200_cit53","doi-asserted-by":"publisher","first-page":"4548","DOI":"10.1038\/s41467-018-06979-4","article-title":"Cloaking nanoparticles with protein corona shield for targeted drug delivery","volume":"9","author":"Oh","year":"2018","journal-title":"Nat. Commun."},{"issue":"10","key":"2026081717142037200_cit54","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1007\/s13346-024-01556-3","article-title":"OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline","volume":"14","author":"d'Avanzo","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"issue":"22","key":"2026081717142037200_cit55","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303266","article-title":"Physiological Barriers and Strategies of Lipid-Based Nanoparticles for Nucleic Acid Drug Delivery","volume":"36","author":"Hu","year":"2024","journal-title":"Adv. Mater."},{"issue":"sup3","key":"2026081717142037200_cit56","doi-asserted-by":"publisher","first-page":"S982","DOI":"10.1080\/21691401.2018.1523181","article-title":"Amelioration of ischaemia reperfusion-induced cerebral injury in mice by liposomes containing Allium cepa fraction administered intranasally","volume":"46","author":"Singh","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"2026081717142037200_cit57","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.seppur.2017.04.021","article-title":"Evaluation of concentration measurement techniques of colloidal nanoparticles for microfiltration and ultrafiltration applications: Inductively coupled plasma-mass spectrometry, nanoparticle tracking analysis and electrospray-scanning mobility particle sizer","volume":"184","author":"Lee","year":"2017","journal-title":"Sep. Purif. Technol."},{"issue":"9","key":"2026081717142037200_cit58","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.3390\/nano11092405","article-title":"Advanced Electron Microscopy of Nanophased Synthetic Polymers and Soft Complexes for Energy and Medicine Applications","volume":"11","author":"Chen","year":"2021","journal-title":"Nanomaterials (Basel)"},{"issue":"9-10","key":"2026081717142037200_cit59","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1002\/smll.201201390","article-title":"Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking","volume":"9","author":"Duan","year":"2013","journal-title":"Small"},{"issue":"20","key":"2026081717142037200_cit60","doi-asserted-by":"publisher","first-page":"4758","DOI":"10.3390\/molecules25204758","article-title":"Understanding the Factors Influencing Chitosan-Based Nanoparticles-Protein Corona Interaction and Drug Delivery Applications","volume":"25","author":"Moraru","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"2026081717142037200_cit61","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1080\/08982104.2022.2071296","article-title":"Protein-liposome interactions: the impact of surface charge and fluidisation effect on protein binding","volume":"33","author":"Triantafyllopoulou","year":"2023","journal-title":"J. Liposome Res."},{"issue":"1-2","key":"2026081717142037200_cit62","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.ijpharm.2018.06.025","article-title":"Visual validation of the measurement of entrapment efficiency of drug nanocarriers","volume":"547","author":"Lv","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"6","key":"2026081717142037200_cit63","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.tips.2021.03.002","article-title":"The Importance of Apparent pKa in the Development of Nanoparticles Encapsulating siRNA and mRNA","volume":"42","author":"Patel","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"issue":"2","key":"2026081717142037200_cit64","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.jconrel.2012.01.027","article-title":"Safety assessment of nanomaterials: implications for nanomedicine","volume":"161","author":"Nystr\u00f6m","year":"2012","journal-title":"J. Control. Release"},{"issue":"6","key":"2026081717142037200_cit65","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.3390\/pharmaceutics15061593","article-title":"Solid Lipid Nanoparticles vs Nanostructured Lipid Carriers: A Comparative Review","volume":"15","author":"Viegas","year":"2023","journal-title":"Pharmaceutics"},{"key":"2026081717142037200_cit66","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jconrel.2021.08.016","article-title":"Influence of lipid matrix composition on biopharmaceutical properties of lipid nanoparticles","volume":"338","author":"Keck","year":"2021","journal-title":"J. Control. Release"},{"issue":"2","key":"2026081717142037200_cit67","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3390\/pharmaceutics14020361","article-title":"Application and Utility of Liposomal Neuroprotective Agents and Biomimetic Nanoparticles for the Treatment of Ischemic Stroke","volume":"14","author":"Fukuta","year":"2022","journal-title":"Pharmaceutics"},{"key":"2026081717142037200_cit68","doi-asserted-by":"publisher","first-page":"8143","DOI":"10.2147\/IJN.S519328","article-title":"Emerging Targeted Delivery Strategies of Nanosystems for Ischemic Stroke Treatment","volume":"20","author":"Ren","year":"2025","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"2026081717142037200_cit69","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1186\/s12951-024-02772-2","article-title":"Targeted pathophysiological treatment of ischemic stroke using nanoparticle-based drug delivery system","volume":"22","author":"Liu","year":"2024","journal-title":"J Nanobiotechnol."},{"issue":"27","key":"2026081717142037200_cit70","doi-asserted-by":"publisher","first-page":"11625","DOI":"10.1039\/D3NR01071F","article-title":"Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke","volume":"15","author":"Wang","year":"2023","journal-title":"Nanoscale"},{"issue":"10","key":"2026081717142037200_cit71","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.3390\/biom14101293","article-title":"Phosphatidylserine: A Novel Target for Ischemic Stroke Treatment","volume":"14","author":"Guo","year":"2024","journal-title":"Biomolecules"},{"issue":"40","key":"2026081717142037200_cit72","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202506276","article-title":"Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome","volume":"12","author":"Litman","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"issue":"13","key":"2026081717142037200_cit73","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202002196","article-title":"Recent Developments in Nanomaterial-Based Shear-Sensitive Drug Delivery Systems","volume":"10","author":"Wang","year":"2021","journal-title":"Adv. Healthc. Mater."},{"issue":"37","key":"2026081717142037200_cit74","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202303717","article-title":"Shear-responsive drug delivery systems in medical devices: focus on thrombosis and bleeding","volume":"33","author":"Zeibi Shirejini","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"2026081717142037200_cit75","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jconrel.2024.12.005","article-title":"Shear force-ROS sequential responsive drug delivery system for improving cerebral thrombosis microcirculation and neurological function","volume":"378","author":"Zhang","year":"2025","journal-title":"J. Control. Release"},{"key":"2026081717142037200_cit76","doi-asserted-by":"publisher","DOI":"10.1177\/1756286418789340","article-title":"Inflammatory molecules might become both biomarkers and therapeutic targets for stroke management","volume":"11","author":"Ramiro","year":"2018","journal-title":"Ther. Adv. Neurol. Disord."},{"issue":"12","key":"2026081717142037200_cit77","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.3390\/antiox10121886","article-title":"Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke","volume":"10","author":"Jelinek","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"2026081717142037200_cit78","doi-asserted-by":"publisher","DOI":"10.1038\/srep12651","article-title":"Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"issue":"3","key":"2026081717142037200_cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2024.e00342","article-title":"Application of targeted liposomes-based salvianolic acid A for the treatment of ischemic stroke","volume":"21","author":"Yang","year":"2024","journal-title":"Neurotherapeutics"},{"key":"2026081717142037200_cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114599","article-title":"Neutrophil-targeted nanomedicine for ischemic stroke therapy","volume":"391","author":"Chen","year":"2026","journal-title":"J. Control. Release"},{"key":"2026081717142037200_cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100674","article-title":"Neutrophil membrane fusogenic nanoliposomal leonurine for targeted ischemic stroke therapy via remodeling cerebral niche and restoring blood-brain barrier integrity","volume":"20","author":"Tang","year":"2023","journal-title":"Mater. Today Bio"},{"issue":"1","key":"2026081717142037200_cit82","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1186\/s12951-024-02641-y","article-title":"Chikusetsu Saponin IVa liposomes modified with a retro-enantio peptide penetrating the blood-brain barrier to suppress pyroptosis in acute ischemic stroke rats","volume":"22","author":"Liang","year":"2024","journal-title":"J Nanobiotechnol."},{"key":"2026081717142037200_cit83","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jconrel.2016.04.038","article-title":"Dual targeted nanocarrier for brain ischemic stroke treatment","volume":"233","author":"Zhao","year":"2016","journal-title":"J. Control. Release"},{"key":"2026081717142037200_cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113955","article-title":"Dual-barrier traversing liposomes with ROS-responsive rigidity tuning for oral ischemic stroke therapy","volume":"385","author":"Zhang","year":"2025","journal-title":"J. Control. Release"},{"key":"2026081717142037200_cit85","doi-asserted-by":"publisher","first-page":"5977","DOI":"10.2147\/IJN.S259938","article-title":"Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury","volume":"15","author":"Zhang","year":"2020","journal-title":"Int. J. Nanomedicine"},{"issue":"2","key":"2026081717142037200_cit86","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2023.100783","article-title":"Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury","volume":"18","author":"Li","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"2026081717142037200_cit87","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.jconrel.2023.11.002","article-title":"Astrocytes and microglia-targeted Danshensu liposomes enhance the therapeutic effects on cerebral ischemia-reperfusion injury","volume":"364","author":"Bai","year":"2023","journal-title":"J. Control. Release"},{"key":"2026081717142037200_cit88","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jconrel.2022.02.036","article-title":"Advanced drug delivery system against ischemic stroke","volume":"344","author":"Zhang","year":"2022","journal-title":"J. Control. Release"},{"issue":"1","key":"2026081717142037200_cit89","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1080\/10717544.2021.1879315","article-title":"Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke","volume":"28","author":"Ma","year":"2021","journal-title":"Drug Deliv."},{"issue":"16","key":"2026081717142037200_cit90","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202200416","article-title":"Annexin V-Modified Platelet-Biomimetic Nanomedicine for Targeted Therapy of Acute Ischemic Stroke","volume":"11","author":"Quan","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"5","key":"2026081717142037200_cit91","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1096\/fj.201601209R","article-title":"Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke","volume":"31","author":"Fukuta","year":"2017","journal-title":"FASEB J."},{"issue":"12","key":"2026081717142037200_cit92","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3390\/biology9120460","article-title":"Tissue Acidosis Associated with Ischemic Stroke to Guide Neuroprotective Drug Delivery","volume":"9","author":"Toth","year":"2020","journal-title":"Biology (Basel)"},{"issue":"18","key":"2026081717142037200_cit93","doi-asserted-by":"publisher","first-page":"17845","DOI":"10.1021\/acsnano.3c03390","article-title":"Smart Liposomal Nanocarrier Enhanced the Treatment of Ischemic Stroke through Neutrophil Extracellular Traps and Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase-Stimulator of Interferon Genes (cGAS-STING) Pathway Inhibition of Ischemic Penumbra","volume":"17","author":"Sun","year":"2023","journal-title":"ACS Nano"},{"issue":"2","key":"2026081717142037200_cit94","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/17425247.2018.1384464","article-title":"Tissue plasminogen activator-based nanothrombolysis for ischemic stroke","volume":"15","author":"Liu","year":"2018","journal-title":"Expert Opin. Drug Deliv."},{"issue":"8","key":"2026081717142037200_cit95","doi-asserted-by":"publisher","DOI":"10.3390\/biom13081256","article-title":"Enhanced Cerebroprotection of Xenon-Loaded Liposomes in Combination with rtPA Thrombolysis for Embolic Ischemic Stroke","volume":"13","author":"Peng","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"2026081717142037200_cit96","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1080\/10717544.2020.1850918","article-title":"Probing the drug delivery strategies in ischemic stroke therapy","volume":"27","author":"Wu","year":"2020","journal-title":"Drug Deliv."},{"issue":"22","key":"2026081717142037200_cit97","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202107126","article-title":"Brain Targeting, Antioxidant Polymeric Nanoparticles for Stroke Drug Delivery and Therapy","volume":"18","author":"Wu","year":"2022","journal-title":"Small"},{"key":"2026081717142037200_cit98","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107494","article-title":"Nanoparticles of resveratrol attenuates oxidative stress and inflammation after ischemic stroke in rats","volume":"94","author":"Ashafaq","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"2026081717142037200_cit99","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3390\/antiox3030472","article-title":"Oxidative Stress and the Use of Antioxidants in Stroke","volume":"3","author":"Shirley","year":"2014","journal-title":"Antioxidants (Basel)"},{"issue":"5","key":"2026081717142037200_cit100","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.4103\/NRR.NRR-D-24-01492","article-title":"Emerging nanoparticle-based strategies to provide therapeutic benefits for stroke","volume":"21","author":"Sundus","year":"2026","journal-title":"Neural Regen. Res."},{"issue":"2","key":"2026081717142037200_cit101","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.109149","article-title":"Advanced nano drug delivery systems for neuroprotection against ischemic stroke","volume":"35","author":"Xie","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"2026081717142037200_cit102","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.jconrel.2023.12.020","article-title":"Selective homing of brain-derived reconstituted lipid nanoparticles to cerebral ischemic area enables improved ischemic stroke treatment","volume":"365","author":"Han","year":"2024","journal-title":"J. Control. Release"},{"issue":"6","key":"2026081717142037200_cit103","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3390\/antiox13060634","article-title":"Ischemic Brain Injury: Involvement of Lipids in the Pathophysiology of Stroke and Therapeutic Strategies","volume":"13","author":"Bernoud-Hubac","year":"2024","journal-title":"Antioxidants (Basel)"},{"issue":"11","key":"2026081717142037200_cit104","doi-asserted-by":"publisher","first-page":"12470","DOI":"10.1021\/acsnano.9b01808","article-title":"Selective Liposomal Transport through Blood Brain Barrier Disruption in Ischemic Stroke Reveals Two Distinct Therapeutic Opportunities","volume":"13","author":"Al-Ahmady","year":"2019","journal-title":"ACS Nano"},{"issue":"Pt A","key":"2026081717142037200_cit105","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124782","article-title":"Panax notoginseng saponins and acetylsalicylic acid co-delivered liposomes for targeted treatment of ischemic stroke","volume":"667","author":"Cui","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"Pt A","key":"2026081717142037200_cit106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejpb.2015.09.020","article-title":"Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions","volume":"97","author":"Fukuta","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"2","key":"2026081717142037200_cit107","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/s12975-023-01125-9","article-title":"Treatment of Ischemic Stroke by Atorvastatin-Loaded PEGylated Liposome","volume":"15","author":"Thomas","year":"2024","journal-title":"Transl. Stroke Res."},{"issue":"7","key":"2026081717142037200_cit108","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1073\/pnas.1912012117","article-title":"Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier","volume":"117","author":"Marcos-Contreras","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"43","key":"2026081717142037200_cit109","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201701921","article-title":"Drug Delivery to the Brain across the Blood-Brain Barrier Using Nanomaterials","volume":"13","author":"Tsou","year":"2017","journal-title":"Small"},{"issue":"10","key":"2026081717142037200_cit110","doi-asserted-by":"publisher","first-page":"5083","DOI":"10.1002\/anie.202010391","article-title":"Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy","volume":"60","author":"Li","year":"2021","journal-title":"Angew. Chem., Int. Ed. Engl."},{"issue":"8","key":"2026081717142037200_cit111","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.3390\/pharmaceutics13081183","article-title":"Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain through BBB","volume":"13","author":"Satapathy","year":"2021","journal-title":"Pharmaceutics"},{"issue":"1","key":"2026081717142037200_cit112","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2023.2179127","article-title":"Brain-targeted delivery of Valsartan using solid lipid nanoparticles labeled with Rhodamine B; a promising technique for mitigating the negative effects of stroke","volume":"30","author":"Sabry","year":"2023","journal-title":"Drug Delivery"},{"key":"2026081717142037200_cit113","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.111084","article-title":"Solid lipid nanoparticle: A potent vehicle of the kaempferol for brain delivery through the blood-brain barrier in the focal cerebral ischemic rat","volume":"397","author":"Ghosh","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"2026081717142037200_cit114","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.colsurfb.2017.10.062","article-title":"Solid lipid nanoparticles for delivery of andrographolide across the blood-brain barrier: in vitro and in vivo evaluation","volume":"161","author":"Graverini","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"24","key":"2026081717142037200_cit115","doi-asserted-by":"publisher","first-page":"7856","DOI":"10.1039\/d3bm00951c","article-title":"Fluorescent liposomal nanocarriers for targeted drug delivery in ischemic stroke therapy","volume":"11","author":"Arul","year":"2023","journal-title":"Biomater. Sci."},{"key":"2026081717142037200_cit116","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102077","article-title":"Neutrophil\/monocyte-targeted dual-ligands modified liposomes delivering puerarin for ischemia stroke treatment","volume":"33","author":"Ling","year":"2025","journal-title":"Mater. Today Bio"},{"key":"2026081717142037200_cit117","doi-asserted-by":"publisher","first-page":"7533","DOI":"10.2147\/IJN.S516316","article-title":"Platelet Membrane-Based Nanoparticles for Targeted Delivery of Deferoxamine to Alleviate Brain Injury Induced by Ischemic Stroke","volume":"20","author":"Wang","year":"2025","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"2026081717142037200_cit118","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s12951-026-04107-9","article-title":"Selenium-doped carbon dots nanozymes hitchhiking tailored liposomes block neuronal pyroptosis through GPX4\/ROS\/NLRP3\/GSDMD axis to attenuate ischemic stroke","volume":"24","author":"Hou","year":"2026","journal-title":"J Nanobiotechnol."},{"issue":"1","key":"2026081717142037200_cit119","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1080\/10717544.2021.2000678","article-title":"Rapid and improved oral absorption of N-butylphthalide by sodium cholate-appended liposomes for efficient ischemic stroke therapy","volume":"28","author":"Zhang","year":"2021","journal-title":"Drug Delivery"},{"key":"2026081717142037200_cit120","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.jconrel.2024.06.017","article-title":"Precisely targeted drug delivery by mesenchymal stem cells-based biomimetic liposomes to cerebral ischemia-reperfusion injured hemisphere","volume":"371","author":"Dong","year":"2024","journal-title":"J. Control. Release"},{"key":"2026081717142037200_cit121","doi-asserted-by":"publisher","first-page":"6177","DOI":"10.2147\/IJN.S458656","article-title":"Targeted Delivery of Macrophage Membrane Biomimetic Liposomes Through Intranasal Administration for Treatment of Ischemic Stroke","volume":"19","author":"Liu","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"2026081717142037200_cit122","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.125.042974","article-title":"Monosialoganglioside-Containing Nanoliposomes Protect Against Acute and Chronic Ischemic Stroke Injury","author":"Ahmad","year":"2026","journal-title":"J. Am. Heart Assoc."},{"key":"2026081717142037200_cit123","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2026.115627","article-title":"Biomimetic propofol liposomes alleviate ischemic stroke by targeting ferroptosis via EGFR\/Nrf2 pathway activation","volume":"263","author":"Fan","year":"2026","journal-title":"Mater. Des."},{"issue":"10","key":"2026081717142037200_cit124","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202520118","article-title":"Amelioration of Post-Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System","volume":"13","author":"Jin","year":"2026","journal-title":"Adv Sci (Weinh)"},{"key":"2026081717142037200_cit125","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202401173","article-title":"Brain-Targeted 9-Phenanthrol-Loaded Lipid Nanoparticle Prevents Brain Edema after Cerebral Ischemia-Reperfusion Injury by Inhibiting the Trpm4 Channel in Mice","volume":"34","author":"Liu","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"2026081717142037200_cit126","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102733","article-title":"A novel dual-action drug TJ94 facilitated by lipid nanocrystal formulations targeting neuroprotection and antithrombosis in ischemic stroke","volume":"36","author":"Chen","year":"2026","journal-title":"Mater. Today Bio"},{"issue":"3","key":"2026081717142037200_cit127","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1056\/NEJMcp1917030","article-title":"Acute ischemic stroke","volume":"383","author":"Powers","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"2026081717142037200_cit128","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1016\/j.brs.2025.08.024","article-title":"Effects of atorvastatin-loaded PEGylated liposomes delivered by magnetic stimulation for stroke treatment","volume":"18","author":"Kim","year":"2025","journal-title":"Brain Stimul."},{"issue":"1","key":"2026081717142037200_cit129","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1146\/annurev-med-050823-094312","article-title":"Contemporary Management of Acute Ischemic Stroke","volume":"76","author":"Ho","year":"2025","journal-title":"Annu. Rev. Med."},{"issue":"10","key":"2026081717142037200_cit130","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.7150\/thno.72167","article-title":"Selective brain entry of lipid nanoparticles in haemorrhagic stroke is linked to biphasic blood-brain barrier disruption","volume":"12","author":"Al-Ahmady","year":"2022","journal-title":"Theranostics"},{"issue":"8","key":"2026081717142037200_cit131","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.4103\/1673-5374.213545","article-title":"A role for lipids as agents to alleviate stroke damage: the neuroprotective effect of 2-hydroxy arachidonic acid","volume":"12","author":"Ugidos","year":"2017","journal-title":"Neural Regen. Res."},{"key":"2026081717142037200_cit132","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.actbio.2025.09.015","article-title":"Lipid nanoparticles hijack neutrophils for enhanced anti-inflammatory and stroke therapy","volume":"206","author":"Cheng","year":"2025","journal-title":"Acta Biomater."},{"issue":"5","key":"2026081717142037200_cit133","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.ymthe.2024.03.004","article-title":"Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke","volume":"32","author":"Nong","year":"2024","journal-title":"Mol. Ther."},{"key":"2026081717142037200_cit134","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122277","article-title":"Improving outcomes in intracerebral hemorrhage through microglia\/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes","volume":"301","author":"Han","year":"2023","journal-title":"Biomaterials"},{"issue":"Pt 1","key":"2026081717142037200_cit135","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/brain\/awq344","article-title":"Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity","volume":"134","author":"Reitmeir","year":"2011","journal-title":"Brain"},{"key":"2026081717142037200_cit136","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1579172","article-title":"Therapeutic potential of natural products in ischemic stroke: targeting angiogenesis","volume":"16","author":"Li","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"3","key":"2026081717142037200_cit137","doi-asserted-by":"publisher","first-page":"416","DOI":"10.4103\/1673-5374.265545","article-title":"Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke","volume":"15","author":"Zhang","year":"2020","journal-title":"Neural Regen. Res."},{"issue":"4","key":"2026081717142037200_cit138","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.1021\/acsnano.3c09817","article-title":"Targeted mRNA Nanoparticles Ameliorate Blood-Brain Barrier Disruption Postischemic Stroke by Modulating Microglia Polarization","volume":"18","author":"Gao","year":"2024","journal-title":"ACS Nano"},{"issue":"7","key":"2026081717142037200_cit139","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.2967\/jnumed.115.154443","article-title":"Improving Cerebral Blood Flow Through Liposomal Delivery of Angiogenic Peptides: Potential of 18F-FDG PET Imaging in Ischemic Stroke Treatment","volume":"56","author":"Hwang","year":"2015","journal-title":"J. Nucl. Med."},{"issue":"52","key":"2026081717142037200_cit140","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202209405","article-title":"Neuroprotective treatments for ischemic stroke: opportunities for nanotechnology","volume":"32","author":"Kong","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"2026081717142037200_cit141","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41596-025-01330-w","article-title":"Preparation of targeted lipid nanoparticles for precision nucleic acid delivery","author":"Geisler","year":"2026","journal-title":"Nat. Protoc."},{"issue":"5","key":"2026081717142037200_cit142","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.molmed.2023.02.004","article-title":"Brain gene therapy with Trojan horse lipid nanoparticles","volume":"29","author":"Pardridge","year":"2023","journal-title":"Trends Mol. Med."},{"issue":"24","key":"2026081717142037200_cit143","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1021\/acs.biochem.3c00371","article-title":"Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection","volume":"62","author":"Tuma","year":"2023","journal-title":"Biochemistry"},{"issue":"1","key":"2026081717142037200_cit144","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1186\/s12951-025-03730-2","article-title":"Neuron-targeted ROS-responsive liposomes for puerarin delivery remodel ischemic microenvironment via microglial modulation and neurovascular regeneration","volume":"23","author":"Chen","year":"2025","journal-title":"J Nanobiotechnol."},{"issue":"1","key":"2026081717142037200_cit145","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/s12951-025-03372-4","article-title":"Celery seed derived reconstituted lipid nanoparticles as an innate neuron-targeted neuroprotective nanomedicine for ischemic stroke treatment","volume":"23","author":"Han","year":"2025","journal-title":"J Nanobiotechnol."},{"issue":"3","key":"2026081717142037200_cit146","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1021\/acs.nanolett.9b04018","article-title":"Liposomal 9-Aminoacridine for Treatment of Ischemic Stroke: From Drug Discovery to Drug Delivery","volume":"20","author":"Wang","year":"2020","journal-title":"Nano Lett."},{"issue":"1","key":"2026081717142037200_cit147","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1186\/s12951-025-03540-6","article-title":"Brain targeted lipid nanoparticles with Hv1 inhibitors alleviate neuroinflammation post-ischemic stroke","volume":"23","author":"Yang","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"26","key":"2026081717142037200_cit148","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201740","article-title":"Delivering the Promise of Gene Therapy with Nanomedicines in Treating Central Nervous System Diseases","volume":"9","author":"Luo","year":"2022","journal-title":"Adv. Sci."},{"issue":"Pt 4","key":"2026081717142037200_cit149","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.147081","article-title":"Unpacking the role of exosomal proteins and nucleic acids in ischemic stroke: Insights from diverse cellular sources","volume":"322","author":"Su","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"2026081717142037200_cit150","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1177\/0271678X19882264","article-title":"miR-98 reduces endothelial dysfunction by protecting blood-brain barrier (BBB) and improves neurological outcomes in mouse ischemia\/reperfusion stroke model","volume":"40","author":"Bernstein","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"3","key":"2026081717142037200_cit151","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1177\/0271678X16649964","article-title":"Hydrogel-delivered brain-derived neurotrophic factor promotes tissue repair and recovery after stroke","volume":"37","author":"Cook","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"2","key":"2026081717142037200_cit152","doi-asserted-by":"publisher","first-page":"404","DOI":"10.4103\/1673-5374.346466","article-title":"Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke","volume":"18","author":"Zhu","year":"2023","journal-title":"Neural Regen. Res."},{"issue":"1","key":"2026081717142037200_cit153","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s43556-023-00159-7","article-title":"MSCs overexpressing GDNF restores brain structure and neurological function in rats with intracerebral hemorrhage","volume":"4","author":"Jiang","year":"2023","journal-title":"Mol. Biomed."},{"issue":"19","key":"2026081717142037200_cit154","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202500598","article-title":"Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Ischemic Stroke Therapy","volume":"37","author":"Jia","year":"2025","journal-title":"Adv. Mater."},{"key":"2026081717142037200_cit155","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.actbio.2023.12.009","article-title":"Oligodendrocyte progenitor cell-specific delivery of lipid nanoparticles loaded with Olig2 synthetically modified messenger RNA for ischemic stroke therapy","volume":"174","author":"Xu","year":"2024","journal-title":"Acta Biomater."},{"key":"2026081717142037200_cit156","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3389\/fimmu.2020.00294","article-title":"Glial Cells: Role of the Immune Response in Ischemic Stroke","volume":"11","author":"Xu","year":"2020","journal-title":"Front. Immunol."},{"issue":"4","key":"2026081717142037200_cit157","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/aps.2016.162","article-title":"Regulation of microglial activation in stroke","volume":"38","author":"Zhao","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"issue":"33","key":"2026081717142037200_cit158","doi-asserted-by":"publisher","first-page":"37478","DOI":"10.1021\/acsami.2c10364","article-title":"Effect of Tetrahedral Framework Nucleic Acids on Neurological Recovery via Ameliorating Apoptosis and Regulating the Activation and Polarization of Astrocytes in Ischemic Stroke","volume":"14","author":"Zhou","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"15","key":"2026081717142037200_cit159","doi-asserted-by":"publisher","first-page":"7363","DOI":"10.1039\/D3NR05844A","article-title":"Framework nucleic acids as promising reactive oxygen species scavengers for anti-inflammatory therapy","volume":"16","author":"Zhu","year":"2024","journal-title":"Nanoscale"},{"key":"2026081717142037200_cit160","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.115131","article-title":"Astrogliosis and glial scar in ischemic stroke - focused on mechanism and treatment","volume":"385","author":"Chen","year":"2025","journal-title":"Exp. Neurol."},{"issue":"16","key":"2026081717142037200_cit161","doi-asserted-by":"publisher","first-page":"8543","DOI":"10.3390\/ijms22168543","article-title":"Repair Mechanisms of the Neurovascular Unit after Ischemic Stroke with a Focus on VEGF","volume":"22","author":"Moon","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026081717142037200_cit162","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.ymthe.2019.09.003","article-title":"A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion","volume":"28","author":"Chen","year":"2020","journal-title":"Mol. Ther."},{"issue":"5","key":"2026081717142037200_cit163","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1007\/s12975-025-01331-7","article-title":"Glial Cell Reprogramming in Ischemic Stroke: A Review of Recent Advancements and Translational Challenges","volume":"16","author":"Gre\u0219i\u021b\u0103","year":"2025","journal-title":"Transl. Stroke Res."},{"key":"2026081717142037200_cit164","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2025.101436","article-title":"Breaking through barrier: The emerging role of nucleic acids-based drug delivery in stroke","volume":"151","author":"Yin","year":"2025","journal-title":"Prog. Mater. Sci."},{"issue":"6","key":"2026081717142037200_cit165","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.4103\/NRR.NRR-D-25-00120","article-title":"Nanomedicines and stroke: Advantages in chronic inflammation treatment and neural regeneration","volume":"21","author":"Liu","year":"2026","journal-title":"Neural Regen. Res."},{"issue":"8","key":"2026081717142037200_cit166","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.3390\/pharmaceutics14081560","article-title":"pH-Responsive Lipid Nanoparticles Achieve Efficient mRNA Transfection in Brain Capillary Endothelial Cells","volume":"14","author":"Sakurai","year":"2022","journal-title":"Pharmaceutics"},{"key":"2026081717142037200_cit167","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122799","article-title":"All in one\" lipid-polymer nanodelivery system for gene therapy of ischemic diseases","volume":"313","author":"Chen","year":"2025","journal-title":"Biomaterials"},{"issue":"2","key":"2026081717142037200_cit168","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1021\/acs.nanolett.4c05186","article-title":"Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain","volume":"25","author":"Han","year":"2025","journal-title":"Nano Lett."},{"issue":"1","key":"2026081717142037200_cit169","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2024.102131","article-title":"Anti-miRNA103\/107 encapsulated in transferrin-conjugated lipid nanoparticles crosses blood-brain barrier and reduces brain ischemic damage","volume":"35","author":"Cepparulo","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"1","key":"2026081717142037200_cit170","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12974-025-03541-0","article-title":"Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage","volume":"22","author":"Reyes-Esteves","year":"2025","journal-title":"J. Neuroinflamm."},{"issue":"12","key":"2026081717142037200_cit171","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.3390\/nano12122072","article-title":"Peptidomimetic Lipid-Nanoparticle-Mediated Knockdown of TLR4 in CNS Protects against Cerebral Ischemia\/Reperfusion Injury in Mice","volume":"12","author":"Ganbold","year":"2022","journal-title":"Nanomaterials (Basel)"},{"issue":"4","key":"2026081717142037200_cit172","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jpha.2018.07.002","article-title":"Analytical methods for investigating in vivo fate of nanoliposomes: A review","volume":"8","author":"Su","year":"2018","journal-title":"J. Pharm. Anal."},{"issue":"2","key":"2026081717142037200_cit173","doi-asserted-by":"publisher","DOI":"10.1002\/sstr.202100118","article-title":"Photothermal-activatable liposome carrying tissue plasminogen activator for photoacoustic image-guided ischemic stroke treatment","volume":"3","author":"Cai","year":"2022","journal-title":"Small Structures"},{"issue":"10","key":"2026081717142037200_cit174","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.7150\/thno.15492","article-title":"Label-free CEST MRI Detection of Citicoline-Liposome Drug Delivery in Ischemic Stroke","volume":"6","author":"Liu","year":"2016","journal-title":"Theranostics"},{"issue":"1-2","key":"2026081717142037200_cit175","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ijpharm.2016.04.046","article-title":"Neuroprotection against cerebral ischemia\/reperfusion injury by intravenous administration of liposomal fasudil","volume":"506","author":"Fukuta","year":"2016","journal-title":"Int. J. Pharm."},{"key":"2026081717142037200_cit176","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114849","article-title":"Blood brain barrier-targeted lipid nanoparticles improved the neuroprotection of Ferrostatin-1 against cerebral ischemic damage in an experimental stroke model","volume":"379","author":"Shi","year":"2024","journal-title":"Exp. Neurol."},{"issue":"12","key":"2026081717142037200_cit177","doi-asserted-by":"publisher","first-page":"5107","DOI":"10.1016\/j.apsb.2023.06.011","article-title":"Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment","volume":"13","author":"Zhang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"5","key":"2026081717142037200_cit178","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.3390\/ijms25052927","article-title":"The Optimization Design of Macrophage Membrane Camouflaging Liposomes for Alleviating Ischemic Stroke Injury through Intranasal Delivery","volume":"25","author":"Liu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"2026081717142037200_cit179","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114542","article-title":"Multidrug-loaded liposomes prevent ischemic stroke through intranasal administration","volume":"162","author":"Yu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"2026081717142037200_cit180","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.jconrel.2016.01.017","article-title":"Intranasal delivery of bFGF with nanoliposomes enhances in vivo neuroprotection and neural injury recovery in a rodent stroke model","volume":"224","author":"Zhao","year":"2016","journal-title":"J. Controlled Release"},{"key":"2026081717142037200_cit181","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3389\/fnins.2018.00453","article-title":"Recent Advances in the Therapeutic and Diagnostic Use of Liposomes and Carbon Nanomaterials in Ischemic Stroke","volume":"12","author":"Fernandes","year":"2018","journal-title":"Front. Neurosci."},{"issue":"11","key":"2026081717142037200_cit182","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.3390\/pharmaceutics17111447","article-title":"Nanoparticle-Mediated Nose-to-Brain Delivery for Ischemic Stroke Therapy: Preclinical Insights","volume":"17","author":"Park","year":"2025","journal-title":"Pharmaceutics"},{"issue":"24","key":"2026081717142037200_cit183","doi-asserted-by":"publisher","first-page":"22065","DOI":"10.1021\/acsnano.5c02105","article-title":"Inflammatory Oriented Nanospheres-Reconstructed Extracellular Matrix in Ischemic Stroke","volume":"19","author":"Gao","year":"2025","journal-title":"ACS Nano"},{"issue":"21","key":"2026081717142037200_cit184","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312897","article-title":"Blood-Brain Barrier-Penetrating and Lesion-Targeting Nanoplatforms Inspired by the Pathophysiological Features for Synergistic Ischemic Stroke Therapy","volume":"36","author":"Tang","year":"2024","journal-title":"Adv. Mater."},{"issue":"11","key":"2026081717142037200_cit185","doi-asserted-by":"publisher","first-page":"17802","DOI":"10.1021\/acsnano.2c08774","article-title":"Exosomes\u2500Nature's Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics","volume":"16","author":"Tenchov","year":"2022","journal-title":"ACS Nano"},{"issue":"37","key":"2026081717142037200_cit186","doi-asserted-by":"publisher","first-page":"33567","DOI":"10.1021\/acsnano.5c11417","article-title":"Hybrid Exosome-Liposome Nanoparticles for Dual Modulation of Neuroinflammation and Lipid Metabolism in Ischemic Stroke","volume":"19","author":"Xie","year":"2025","journal-title":"ACS Nano"},{"issue":"1","key":"2026081717142037200_cit187","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/s12951-022-01450-5","article-title":"Advances of nano drug delivery system for the theranostics of ischemic stroke","volume":"20","author":"Lv","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"2026081717142037200_cit188","doi-asserted-by":"publisher","first-page":"445","DOI":"10.2147\/IJN.S231853","article-title":"Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies","volume":"15","author":"Alkaff","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"1-2","key":"2026081717142037200_cit189","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41434-021-00304-3","article-title":"Progress on siRNA-based gene therapy targeting secondary injury after intracerebral hemorrhage","volume":"30","author":"Almarghalani","year":"2023","journal-title":"Gene Ther."},{"issue":"1","key":"2026081717142037200_cit190","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1186\/s12951-024-02673-4","article-title":"Polymeric nanocarriers delivery systems in ischemic stroke for targeted therapeutic strategies","volume":"22","author":"Zhu","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"2026081717142037200_cit191","doi-asserted-by":"publisher","first-page":"4377","DOI":"10.2147\/IJN.S463333","article-title":"Advances in Engineered Nanoparticles for the Treatment of Ischemic Stroke by Enhancing Angiogenesis","volume":"19","author":"Wang","year":"2024","journal-title":"Int. J. Nanomed."}],"container-title":["ACS Biomaterials Science &amp; Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.6c00712","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/abseba\/article-pdf\/12\/8\/3985\/66330722\/ab-2026-00712j.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/abseba\/article-pdf\/12\/8\/3985\/66330722\/ab-2026-00712j.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:32:49Z","timestamp":1787002369000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/abseba\/article\/12\/8\/3985\/5236765\/Spatiotemporal-Strategies-for-Lipid-Based"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":191,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,29]]},"published-print":{"date-parts":[[2026,8,10]]}},"URL":"https:\/\/doi.org\/10.1021\/acsbiomaterials.6c00712","relation":{},"ISSN":["2373-9878"],"issn-type":[{"value":"2373-9878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]}}}