{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:46:07Z","timestamp":1791794767059,"version":"4.3.4"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2019C04020"],"award-info":[{"award-number":["2019C04020"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03075"],"award-info":[{"award-number":["2024C03075"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471400"],"award-info":[{"award-number":["32471400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ24E020002"],"award-info":[{"award-number":["LZ24E020002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Astaxanthin is a high-value ketocarotenoid with potent antioxidant activity and wide applications in nutraceutical, cosmetic, and aquaculture industries. The green microalga Haematococcus pluvialis represents the most promising natural source; however, its efficient production requires precise control of growth and stress conditions, while free cells remain susceptible to environmental and mechanical stress. Hydrogel encapsulation offers a protective microenvironment, yet conventional alginate systems are limited by poor mechanical stability and uncontrolled swelling. Here, we report calcium alginate-based biomimetic mineralized core-shell capsules for the encapsulation, cultivation, and high-light-induced astaxanthin production of H. pluvialis. Capsules were fabricated by ionic crosslinking of alginate containing KH2PO4 with a CMC\/CaCl2 precursor solution, enabling in situ calcium phosphate formation within the capsule shell. Comprehensive characterization confirmed successful mineralization, reduced swelling, enhanced inorganic content, and improved mechanical strength. Encapsulated cells exhibited sustained growth and metabolic activity under moderate light without cytotoxic effects. Upon high-light exposure, both free and encapsulated cells showed a characteristic transition from green to red, accompanied by a significant increase in astaxanthin content. Notably, astaxanthin accumulation was comparable to that of controls. This study establishes a scalable encapsulation strategy that enhances structural stability without compromising biological function, offering potential for industrial microalgal cultivation and astaxanthin production.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.6c00751","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:01:25Z","timestamp":1790463685000},"page":"5380-5389","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Mineralized Capsules for\n                    <i>Haematococcus pluvialis<\/i>\n                    Clustering and Functional Regulation"],"prefix":"10.1021","volume":"12","author":[{"given":"Peihan","family":"Kang","sequence":"first","affiliation":[{"name":"Zhejiang Sci-Tech University , , , ,","place":["Hangzhou, Zhejiang, China, 310018"]},{"name":"Zhejiang Sci-Tech University , , , ,","place":["Hangzhou, Zhejiang, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Sci-Tech University , , , ,","place":["Hangzhou, Zhejiang, China, 310018"]},{"name":"Zhejiang Sci-Tech University , , , ,","place":["Hangzhou, Zhejiang, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-7058","authenticated-orcid":true,"given":"Xiangdong","family":"Kong","sequence":"additional","affiliation":[{"name":"Zhejiang Sci-Tech University , , , ,","place":["Hangzhou, Zhejiang, China, 310018"]},{"name":"Zhejiang Sci-Tech University , , , ,","place":["Hangzhou, Zhejiang, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1225-3051","authenticated-orcid":true,"given":"Ruibo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Zhejiang Sci-Tech University , , , ,","place":["Hangzhou, Zhejiang, China, 310018"]},{"name":"Zhejiang Sci-Tech University , , , ,","place":["Hangzhou, Zhejiang, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"2026101202065147400_cit1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1737001","article-title":"Astaxanthin as a neuroprotective modulator of synaptic plasticity, learning, and memory: mechanistic insights and therapeutic perspectives in neurodegenerative aging","volume":"17","author":"Guo","year":"2026","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"2026101202065147400_cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41538-025-00653-y","article-title":"Food-grade nanostructured delivery systems for oral administration of astaxanthin: Bioprocessing strategies and therapeutic applications","volume":"10","author":"Jiang","year":"2025","journal-title":"NPJ Sci. Food"},{"key":"2026101202065147400_cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.141428","article-title":"Advance toward function, production, and delivery of natural astaxanthin: A promising candidate for food ingredients with future perspectives","volume":"463","author":"Zhang","year":"2025","journal-title":"Food Chem."},{"key":"2026101202065147400_cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.Biotechadv.2025.108519","article-title":"Advancements of astaxanthin production in Haematococcus pluvialis: Update insight and way forward","volume":"79","author":"Cui","year":"2025","journal-title":"Biotechnol. Adv."},{"key":"2026101202065147400_cit5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.tifs.2023.04.014","article-title":"Chemical inducers regulate ROS signalling to stimulate astaxanthin production in Haematococcus pluvialis under environmental stresses: A review","volume":"136","author":"Li","year":"2023","journal-title":"Trends Food Sci. Technol."},{"issue":"4","key":"2026101202065147400_cit6","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1080\/07388551.2024.2410364","article-title":"Astaxanthin biosynthesis for functional food development and space missions","volume":"45","author":"Xie","year":"2025","journal-title":"Crit. Rev. Biotechnol."},{"issue":"1","key":"2026101202065147400_cit7","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms14010253","article-title":"Resolving the \u201cThick-Wall Challenge\u201d in Haematococcus pluvialis: From Metabolic Reprogramming to Clinical Translation","volume":"14","author":"Chen","year":"2026","journal-title":"Microorganisms"},{"key":"2026101202065147400_cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.Biortech.2023.130150","article-title":"The combination of uridine and nitrogen-deprivation promotes the efficient formation of astaxanthin-rich motile cells in Haematococcus pluvialis","volume":"393","author":"Hailiang","year":"2024","journal-title":"Bioresour. 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