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In this work, we demonstrated the multifunctional nanoparticle (QL@PS NP)-armored Lactobacillus rhamnosus (LAB) with inflammation targeting and regulation activity for inflammatory bowel disease (IBD) treatment. QL@PS NPs were assembled by quercetin (Que), lipoic acid (LA), and phosphatidylserine (PS), which could target macrophages and degrade in reactive oxygen species (ROS)-rich lesion sites, exhibiting excellent antioxidant and anti-inflammatory capability in vitro. QL@PS NPs were coated on the surface of thiolated LAB under a cell-friendly condition, and the resulting nanoarmored probiotic (LAB@NPs) could protect LAB from the gastrointestinal assaults and ROS damage. LAB@NPs are more likely to be up-taken by macrophages, scavenging oxidative stress and regulating the inflammatory microenvironment of colitis lesions through the synergistic effect of probiotics and QL@PS NPs. In vivo experimental results certified that LAB@NPs achieved notable lesion-specific therapeutic efficacy in mouse colitis models, significantly ameliorating colon shortening, reducing inflammatory reactions and pathological tissue damage. This work provides a facile and effective strategy to construct nanoarmored probiotics for therapy of IBD.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.6c00800","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T02:01:16Z","timestamp":1785981676000},"page":"5051-5062","source":"Crossref","is-referenced-by-count":0,"title":["Oral Nanoarmored\n                    <i>Lactobacillus rhamnosus<\/i>\n                    with Inflammation Targeting and Scavenging Activities for Colitis Lesion-Specific Therapy"],"prefix":"10.1021","volume":"12","author":[{"given":"Wen","family":"Li","sequence":"first","affiliation":[{"name":"Anhui Normal University , , ,","place":["Wuhu, P. R. 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