{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:02:49Z","timestamp":1789376569390,"version":"build-2803163510"},"reference-count":28,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["2023AH050063"],"award-info":[{"award-number":["2023AH050063"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2008085QE210"],"award-info":[{"award-number":["2008085QE210"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) is characterized by a chronic inflammatory microenvironment with excessive reactive oxygen species (ROS) and progressive cartilage degeneration. To address these challenges, we developed a ROS-responsive, water\u2013oil biphasic separable microneedle patch (CKCA MN) for transdermal therapy. This microneedle utilizes hyaluronic acid (HA) as a rapidly dissolving substrate, and its needle tip comprises a coordination-crosslinked hydrogel formed by Ce3+ and alendronate (Aln), loaded with cinnamaldehyde (CM) as the oil-phase carrier encapsulating kartogenin (KGN). The needle tip can rapidly dissociate from the base and selectively remain in the dermis, enabling localized therapeutic delivery for OA. Within the needle tip, the aqueous phase degrades under the trigger of ROS. Ce3+ efficiently scavenges ROS via the Ce3+\/Ce4+ redox cycle, while Aln binds to the bone surface and suppresses osteoclast activity. Concurrently, the oil phase can directly neutralize ROS and facilitate sustained release of KGN, which drives chondrogenic differentiation of endogenous progenitor cells. Critically, the oil phase can precisely regulate the degradation kinetics of the Ce\u2013Aln hydrogel, thereby establishing a dual-phase release curve: Ce3+-driven anti-inflammatory effects followed by KGN-mediated cartilage matrix synthesis and structural restoration. The presence of the oil phase can reduce the degradation rate of the needle tip, from 24 to 120 h of degradation release. The treatment with the CKCA MN resulted in a 3\u20134-fold decrease in inflammatory factors and cartilage remodeling. Collectively, the CKCA MN leverages ROS-responsive degradation to spatiotemporally regulate drug release, thereby achieving a synergistic therapeutic cascade of \"anti-inflammation, subchondral bone protection, and cartilage regeneration,\" which addresses the interconnected pathological mechanisms underlying OA progression.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.6c00816","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:01:53Z","timestamp":1787004113000},"page":"4803-4818","source":"Crossref","is-referenced-by-count":0,"title":["ROS-Responsive, Water\u2013Oil Biphasic Hydrogel-Based Separable Microneedle System for Intra-Articular Delivery in Osteoarthritis Therapy"],"prefix":"10.1021","volume":"12","author":[{"given":"Xian","family":"Zhang","sequence":"first","affiliation":[{"name":"Anhui University , , 111 Jiulong Road , , ,","place":["Hefei, Anhui Province, P. R. China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Anhui University , , 111 Jiulong Road , , ,","place":["Hefei, Anhui Province, P. R. China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChengRong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui University , , 111 Jiulong Road , , ,","place":["Hefei, Anhui Province, P. R. China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoQing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui University , , 111 Jiulong Road , , ,","place":["Hefei, Anhui Province, P. R. China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Ningbo Zhengli Pharmaceutical Packaging Co., Ltd. , 38 Hongsheng Road , , ,","place":["Ningbo, Zhejiang Province, P. R. China, 315033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Ye","sequence":"additional","affiliation":[{"name":"Ningbo Zhengli Pharmaceutical Packaging Co., Ltd. , 38 Hongsheng Road , , ,","place":["Ningbo, Zhejiang Province, P. R. China, 315033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-1126","authenticated-orcid":true,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Anhui University , , 111 Jiulong Road , , ,","place":["Hefei, Anhui Province, P. R. China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1467-915X","authenticated-orcid":true,"given":"Guoqing","family":"Yan","sequence":"additional","affiliation":[{"name":"Anhui University , , 111 Jiulong Road , , ,","place":["Hefei, Anhui Province, P. R. China, 230601"]},{"name":"Xi'an Jiaotong University , , ,","place":["Xi'an, China, 710049"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"11","key":"2026091400071096900_cit1","doi-asserted-by":"publisher","first-page":"8125","DOI":"10.1021\/acsnano.3c11848","article-title":"Nanomedicines Promote Cartilage Regeneration in Osteoarthritis by Synergistically Enhancing Chondrogenesis of Mesenchymal Stem Cells and Regulating Inflammatory Environment","volume":"18","author":"Cui","year":"2024","journal-title":"ACS Nano"},{"issue":"32","key":"2026091400071096900_cit2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401507","article-title":"Controlled Release of Ceria and Ferric Oxide Nanoparticles via Collagen Hydrogel for Enhanced Osteoarthritis Therapy","volume":"13","author":"Chen","year":"2024","journal-title":"Adv. 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