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Tumor treating fields (TTFs) provide a non-invasive strategy by disrupting cancer cell mitosis using alternating electric fields, but current systems rely on external electrodes and suffer from low field penetration. By producing localized electric fields in response to mechanical stimulation, implantable piezoelectric nanofibers present a viable self-powered substitute. Here, we designed composite nanofibers by incorporating Mn\u2013Ti bimetallic metal\u2013organic framework (MT-MOF) into electrospun polyacrylonitrile (PAN) nanofibers. These composite nanofibers enhance piezoelectric output, enabling physiological motion-activated in situ TTFs generation for localized therapy without external wiring. Under ultrasound (US) stimulation, MT-MOF loaded nanofibers exhibits an output voltage of 0.35 V, generating adequate alternating electric fields to induce tumor apoptosis and ultimately promote cancer cell death. Good biocompatibility toward normal cells was demonstrated. In vivo experiments demonstrated that MT-MOF\/PAN nanofibers effectively suppressed GBM tumor growth, highlighting their potential as a platform for implantable cancer treatment systems.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.6c00905","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:11:56Z","timestamp":1784034716000},"page":"4562-4572","source":"Crossref","is-referenced-by-count":0,"title":["Metal\u2013Organic Framework Composite Piezoelectric Nanofibers for Wireless Tumor Treating Fields Therapy"],"prefix":"10.1021","volume":"12","author":[{"given":"Shiqin","family":"Dai","sequence":"first","affiliation":[{"name":"National Institute for Materials Science (NIMS) , , , ,","place":["Tsukuba, Ibaraki, Japan, 305-0044"]},{"name":"University of Tsukuba , , , ,","place":["Tsukuba, Ibaraki, Japan, 305-0006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5617-4726","authenticated-orcid":true,"given":"Ahmed","family":"Nabil","sequence":"additional","affiliation":[{"name":"National Institute for Materials Science (NIMS) , , , ,","place":["Tsukuba, Ibaraki, Japan, 305-0044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"University of Tsukuba , , ,","place":["Tsukuba, Japan, 305-8575"]},{"name":"University of Tsukuba Hospital , , ,","place":["Tsukuba, Japan, 305-8576"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyasha","family":"Abulimiti","sequence":"additional","affiliation":[{"name":"University of Tsukuba , , ,","place":["Tsukuba, Japan, 305-8575"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sugawara","sequence":"additional","affiliation":[{"name":"University of Tsukuba Hospital , , ,","place":["Tsukuba, Japan, 305-8576"]},{"name":"University of Tsukuba , , ,","place":["Tsukuba, Japan, 305-8575"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Ebara","sequence":"additional","affiliation":[{"name":"National Institute for Materials Science (NIMS) , , , ,","place":["Tsukuba, Ibaraki, Japan, 305-0044"]},{"name":"University of Tsukuba , , , ,","place":["Tsukuba, Ibaraki, Japan, 305-0006"]},{"name":"Tokyo University of Science , , ,","place":["Tokyo, Japan, 125-8585"]},{"name":"Chulalongkorn University , , ,","place":["Bangkok, Thailand, 10330"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"issue":"7","key":"2026081717161335900_cit1","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1001\/jama.2023.0023","article-title":"Glioblastoma and other primary brain malignancies in adults: a review","volume":"329","author":"Schaff","year":"2023","journal-title":"JAMA"},{"issue":"1","key":"2026081717161335900_cit2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17010146","article-title":"Glioblastoma: Clinical Presentation, Multidisciplinary Management, and Long-Term Outcomes","volume":"17","author":"Sipos","year":"2025","journal-title":"Cancers"},{"issue":"2","key":"2026081717161335900_cit3","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13020216","article-title":"Maximal safe resection in glioblastoma surgery: a systematic review of advanced intraoperative image-guided techniques","volume":"13","author":"Bonosi","year":"2023","journal-title":"Brain Sci."},{"issue":"1","key":"2026081717161335900_cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05301-9","article-title":"The tumour microenvironment, treatment resistance and recurrence in glioblastoma","volume":"22","author":"White","year":"2024","journal-title":"J. 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