{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T13:24:15Z","timestamp":1794230655658,"version":"4.9.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["T1 CRC-2025-00116"],"award-info":[{"award-number":["T1 CRC-2025-00116"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031554","name":"PRIMA Qu?bec","doi-asserted-by":"publisher","award":["PSOV2"],"award-info":[{"award-number":["PSOV2"]}],"id":[{"id":"10.13039\/100031554","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Sciences and Engineering Research Council of Canada (NSERC)","award":["RGPIN-2020-06778"],"award-info":[{"award-number":["RGPIN-2020-06778"]}],"id":[{"id":"https:\/\/ror.org\/01h531d29","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Canada 150 Research Chair in Bacterial Cell Biology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Surface-associated and device-related bacterial infections require materials that can both eliminate pathogens and prevent microbial colonization. However, antibacterial activity in solution and antifouling performance at interfaces are governed by distinct physicochemical principles, making their integration within a single material challenging. Here, we report a modular bottlebrush polymer (BBP) platform that decouples these functions through architectural design. A library of seven BBPs with monoblock and ABA triblock architectures was synthesized to independently control side-chain charge distribution and interfacial hydration. Multivalent cationic side chains promoted efficient bacterial killing in solution, whereas hydrated PEG or zwitterionic bottlebrush layers anchored by cationic termini formed stable antifouling coatings. In diabetic mice, the BBPs showed no evidence of local irritation, systemic toxicity, or impaired wound healing. In an infected wound model, bactericidal BBPs reduced bacterial burden, while antifouling BBPs suppressed local inflammation. Their combined application improved therapeutic outcomes, demonstrating the benefit of a functionally decoupled strategy. Collectively, these findings establish a generalizable architectural framework for designing multifunctional anti-infective materials.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.6c01161","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:01:20Z","timestamp":1791266480000},"page":"6484-6498","source":"Crossref","is-referenced-by-count":0,"title":["A Modular Bottlebrush Polymer Platform for Decoupled Antibacterial and Antifouling Strategies against Wound Infections"],"prefix":"10.1021","volume":"12","author":[{"given":"Chang-Sheng","family":"Wang","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-9317","authenticated-orcid":true,"given":"Cecile","family":"Berne","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , ,","place":["Montr\u00e9al, Canada, H3C 3J7"]},{"name":"Institut Courtois d\u2019Innovation Biom\u00e9dicale , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Dufresne","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Qu\u00e9bec \u00e0 Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H2X 1Y4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Raj","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Filippini","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermine","family":"Counil","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9392-1198","authenticated-orcid":true,"given":"Quoc Thang","family":"Phan","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duy Anh","family":"Pham","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Quebec, Canada, H3C 3J7"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Hassanpour","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Peng","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Hsuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Quebec, Canada, H3C 3J7"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florina G.","family":"Halmac","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves V.","family":"Brun","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , ,","place":["Montr\u00e9al, Canada, H3C 3J7"]},{"name":"Institut Courtois d\u2019Innovation Biom\u00e9dicale , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3342-3179","authenticated-orcid":true,"given":"Xavier","family":"Banquy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Qu\u00e9bec, Canada, H3T 1J4"]},{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Quebec, Canada, H3C 3J7"]},{"name":"Universit\u00e9 de Montr\u00e9al , , , ,","place":["Montr\u00e9al, Quebec, Canada, H3C 3J7"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"2026110907070407900_cit1","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s40121-025-01143-0","article-title":"Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control\u2014A Narrative Review","volume":"14","author":"Sandu","year":"2025","journal-title":"Infect. Dis. Ther."},{"issue":"3","key":"2026110907070407900_cit2","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s12088-024-01221-w","article-title":"Current Strategies for Combating Biofilm-Forming Pathogens in Clinical Healthcare-Associated Infections","volume":"64","author":"Biswas","year":"2024","journal-title":"Indian J. Microbiol."},{"issue":"1","key":"2026110907070407900_cit3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s44259-024-00046-3","article-title":"Mechanisms of antimicrobial resistance in biofilms","volume":"2","author":"Liu","year":"2024","journal-title":"NPJ Antimicrob. Resist."},{"issue":"6870","key":"2026110907070407900_cit4","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"issue":"12","key":"2026110907070407900_cit5","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/nbt1267","article-title":"Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies","volume":"24","author":"Hancock","year":"2006","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"2026110907070407900_cit6","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1021\/jm900999h","article-title":"Structure\u2013Activity Relationships of Polymyxin Antibiotics","volume":"53","author":"Velkov","year":"2010","journal-title":"J. Med. Chem."},{"issue":"1","key":"2026110907070407900_cit7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.coi.2005.11.004","article-title":"Cationic host defense (antimicrobial) peptides","volume":"18","author":"Brown","year":"2006","journal-title":"Curr. Opin. Immunol."},{"key":"2026110907070407900_cit8","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202500583","article-title":"Uncovering Key Characteristics of Antibacterial Peptides through Machine Learning","volume":"47","author":"Roh","year":"2026","journal-title":"Macromol. Rapid Commun."},{"key":"2026110907070407900_cit9","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.actbio.2025.09.030","article-title":"Broad-spectrum antibacterial peptidopolysaccharides for targeted therapy of a drug-resistant bacterial liver abscess","volume":"206","author":"Yu","year":"2025","journal-title":"Acta Biomater."},{"issue":"13","key":"2026110907070407900_cit10","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.1021\/acs.langmuir.9b03266","article-title":"Film Properties and Antimicrobial Efficacy of Quaternized PDMAEMA Brushes: Short vs Long Alkyl Chain Length","volume":"36","author":"Koufakis","year":"2020","journal-title":"Langmuir"},{"issue":"8","key":"2026110907070407900_cit11","doi-asserted-by":"publisher","first-page":"9803","DOI":"10.1021\/acsomega.3c10233","article-title":"Contact-Killing Antibacterial Polystyrene Polymerized Using a Quaternized Cationic Initiator","volume":"9","author":"Jitsuhiro","year":"2024","journal-title":"ACS Omega"},{"issue":"5","key":"2026110907070407900_cit12","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1021\/bm061150q","article-title":"The Chemistry and Applications of Antimicrobial Polymers: A State-of-the-Art Review","volume":"8","author":"Kenawy","year":"2007","journal-title":"Biomacromolecules"},{"key":"2026110907070407900_cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2025.114384","article-title":"Influence of end-group functionality and composition on the antifungal activity and biocompatibility of polyacrylamide-based polymers","volume":"241","author":"Gmedhin","year":"2025","journal-title":"Eur. Polym. J."},{"issue":"12","key":"2026110907070407900_cit14","doi-asserted-by":"publisher","first-page":"5350","DOI":"10.1021\/acs.biomac.2c01187","article-title":"Shape Matters: Highly Selective Antimicrobial Bottle Brush Copolymers via a One-Pot RAFT Polymerization Approach","volume":"23","author":"Lehnen","year":"2022","journal-title":"Biomacromolecules"},{"issue":"46","key":"2026110907070407900_cit15","doi-asserted-by":"publisher","first-page":"29657","DOI":"10.1021\/acsomega.0c01355","article-title":"Fluorinated Quaternary Chitosan Derivatives: Synthesis, Characterization, Antibacterial Activity, and Killing Kinetics","volume":"5","author":"Cele","year":"2020","journal-title":"ACS Omega"},{"issue":"11","key":"2026110907070407900_cit16","doi-asserted-by":"publisher","first-page":"5981","DOI":"10.1073\/pnas.111143098","article-title":"Designing surfaces that kill bacteria on contact","volume":"98","author":"Tiller","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"7","key":"2026110907070407900_cit17","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1021\/acs.biomac.5c00145","article-title":"Poly (Oligo (Ethylene Glycol) Methacrylate)-Based Polymers in Biomedical Applications: Preparation and Applications","volume":"26","author":"Singh","year":"2025","journal-title":"Biomacromolecules"},{"issue":"14","key":"2026110907070407900_cit18","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1039\/d1tb02675e","article-title":"Recent progress and perspectives in applications of 2-methacryloyloxyethyl phosphorylcholine polymers in biodevices at small scales","volume":"10","author":"Seetasang","year":"2022","journal-title":"J. Mater. Chem. B"},{"issue":"24","key":"2026110907070407900_cit19","doi-asserted-by":"publisher","first-page":"16847","DOI":"10.1021\/acsapm.5c03592","article-title":"Stimuli-Responsive \u201cArm-First\u201d Star Copolymers for Antibacterial Activity and Biocompatibility","volume":"7","author":"Aquib","year":"2025","journal-title":"ACS Appl. Polym. Mater."},{"issue":"5","key":"2026110907070407900_cit20","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202300452","article-title":"Effect of Star Topology Versus Linear Polymers on Antifungal Activity and Mammalian Cell Toxicity","volume":"24","author":"Schaefer","year":"2024","journal-title":"Macromol. Biosci."},{"issue":"7","key":"2026110907070407900_cit21","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1021\/acs.biomac.3c00150","article-title":"Synthetic Star Nanoengineered Antimicrobial Polymers as Antibiofilm Agents: Bacterial Membrane Disruption and Cell Aggregation","volume":"24","author":"Laroque","year":"2023","journal-title":"Biomacromolecules"},{"issue":"7","key":"2026110907070407900_cit22","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1021\/acs.biomac.3c00298","article-title":"Topology Effects of Poly(2-ethyl-2-oxazoline) Brushes with Various Architectures for Antifouling Behavior under Shear Flow","volume":"24","author":"Xing","year":"2023","journal-title":"Biomacromolecules"},{"key":"2026110907070407900_cit23","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.colsurfb.2017.08.021","article-title":"Effects of polymer topology on biointeractions of polymer brushes: Comparison of cyclic and linear polymers","volume":"159","author":"Wei","year":"2017","journal-title":"Colloids Surf., B"},{"issue":"45","key":"2026110907070407900_cit24","doi-asserted-by":"publisher","first-page":"19057","DOI":"10.1039\/d4sc05797j","article-title":"Effect of cyclic topology versus linear terpolymers on antibacterial activity and biocompatibility: antimicrobial peptide avatars","volume":"15","author":"Aquib","year":"2024","journal-title":"Chem. Sci."},{"key":"2026110907070407900_cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2021.101387","article-title":"Bottlebrush polymers: From controlled synthesis, self-assembly, properties to applications","volume":"116","author":"Li","year":"2021","journal-title":"Prog. Polym. Sci."},{"issue":"6","key":"2026110907070407900_cit26","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1021\/acs.biomac.1c00247","article-title":"Nonbiofouling Coatings Using Bottlebrushes with Concentrated Polymer Brush Architecture","volume":"22","author":"Yoshikawa","year":"2021","journal-title":"Biomacromolecules"},{"key":"2026110907070407900_cit27","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.actbio.2026.02.004","article-title":"Mucin-inspired bottlebrush polymer hydrogel for postoperative adhesion prevention","volume":"213","author":"Ren","year":"2026","journal-title":"Acta Biomater."},{"issue":"12","key":"2026110907070407900_cit28","doi-asserted-by":"publisher","first-page":"4140","DOI":"10.1021\/acs.chemmater.8b01676","article-title":"Intermolecular Interactions between Bottlebrush Polymers Boost the Protection of Surfaces against Frictional Wear","volume":"30","author":"Faivre","year":"2018","journal-title":"Chem. Mater."},{"issue":"17","key":"2026110907070407900_cit29","doi-asserted-by":"publisher","first-page":"6199","DOI":"10.1021\/ja501770y","article-title":"Bioinspired Bottle-Brush Polymer Exhibits Low Friction and Amontons-like Behavior","volume":"136","author":"Banquy","year":"2014","journal-title":"J. Am. Chem. Soc."},{"issue":"19","key":"2026110907070407900_cit30","doi-asserted-by":"publisher","first-page":"15469","DOI":"10.1039\/c5ra24361k","article-title":"Antibacterial low molecular weight cationic polymers: dissecting the contribution of hydrophobicity, chain length and charge to activity","volume":"6","author":"Grace","year":"2016","journal-title":"RSC Adv."},{"issue":"9","key":"2026110907070407900_cit31","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1021\/cr940534g","article-title":"Atom Transfer Radical Polymerization","volume":"101","author":"Matyjaszewski","year":"2001","journal-title":"Chem. Rev."},{"issue":"9","key":"2026110907070407900_cit32","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1021\/acschembio.3c00351","article-title":"Cationic Polymers Enable Internalization of Negatively Charged Chemical Probes into Bacteria","volume":"18","author":"Lembke","year":"2023","journal-title":"ACS Chem. Biol."},{"issue":"5","key":"2026110907070407900_cit33","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1002\/anie.201808987","article-title":"Biomimetic Bottlebrush Polymer Coatings for Fabrication of Ultralow Fouling Surfaces","volume":"58","author":"Xia","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"issue":"8","key":"2026110907070407900_cit34","doi-asserted-by":"publisher","first-page":"12687","DOI":"10.1021\/acsnano.1c04206","article-title":"Functional hydrogels as wound dressing to enhance wound healing","volume":"15","author":"Liang","year":"2021","journal-title":"ACS Nano"},{"issue":"4","key":"2026110907070407900_cit35","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00020-18","article-title":"Methicillin-resistant Staphylococcus aureus: molecular characterization, evolution, and epidemiology","volume":"31","author":"Lakhundi","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"issue":"1","key":"2026110907070407900_cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-11891-1","article-title":"Quaternized chitosan derivatives inhibit growth and affect biofilm formation of Staphylococcus aureus","volume":"15","author":"Miranda","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"2026110907070407900_cit37","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.bbamem.2008.08.023","article-title":"Lipid domains in bacterial membranes and the action of antimicrobial agents","volume":"1788","author":"Epand","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"11","key":"2026110907070407900_cit38","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1021\/bm900784x","article-title":"Structural Determinants of Antimicrobial Activity and Biocompatibility in Membrane-Disrupting Methacrylamide Random Copolymers","volume":"10","author":"Palermo","year":"2009","journal-title":"Biomacromolecules"},{"issue":"12","key":"2026110907070407900_cit39","doi-asserted-by":"publisher","first-page":"4128","DOI":"10.1021\/ja044205+","article-title":"Amphiphilic Polymethacrylate Derivatives as Antimicrobial Agents","volume":"127","author":"Kuroda","year":"2005","journal-title":"J. Am. Chem. Soc."},{"issue":"11","key":"2026110907070407900_cit40","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.162","article-title":"Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers","volume":"1","author":"Lam","year":"2016","journal-title":"Nat. Microbiol."},{"issue":"10","key":"2026110907070407900_cit41","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202312651","article-title":"Anisotropy in Antimicrobial Bottle Brush Copolymers and Its Influence on Biological Activity","volume":"34","author":"Lehnen","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"2026110907070407900_cit42","doi-asserted-by":"publisher","DOI":"10.3390\/nano10030536","article-title":"Renewable Fabric Surface-Initiated ATRP Polymerizations: Towards Mixed Polymer Brushes","volume":"10","author":"Raj","year":"2020","journal-title":"Nanomaterials"},{"issue":"7","key":"2026110907070407900_cit43","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.progpolymsci.2008.05.001","article-title":"Cylindrical molecular brushes: Synthesis, characterization, and properties","volume":"33","author":"Sheiko","year":"2008","journal-title":"Prog. Polym. Sci."},{"issue":"8","key":"2026110907070407900_cit44","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1039\/c4cs00329b","article-title":"Structure, function, self-assembly, and applications of bottlebrush copolymers","volume":"44","author":"Verduzco","year":"2015","journal-title":"Chem. Soc. Rev."},{"issue":"5","key":"2026110907070407900_cit45","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1038\/jid.2015.21","article-title":"Silver Sulfadiazine Retards Wound Healing in Mice via Alterations in Cytokine Expression","volume":"135","author":"Rosen","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"2026110907070407900_cit46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1159\/000093928","article-title":"Silver in Health Care: Antimicrobial Effects and Safety in Use","volume":"33","author":"Lansdown","year":"2026","journal-title":"Biofunctional Textiles and the Skin"},{"issue":"1","key":"2026110907070407900_cit47","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.biotechadv.2008.09.002","article-title":"Silver nanoparticles as a new generation of antimicrobials","volume":"27","author":"Rai","year":"2009","journal-title":"Biotechnol. Adv."},{"issue":"2","key":"2026110907070407900_cit48","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.burns.2006.06.010","article-title":"Effect of silver on burn wound infection control and healing: Review of the literature","volume":"33","author":"Atiyeh","year":"2007","journal-title":"Burns"},{"issue":"9","key":"2026110907070407900_cit49","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrmicro.2016.94","article-title":"Biofilms: an emergent form of bacterial life","volume":"14","author":"Flemming","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"2026110907070407900_cit50","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.cmi.2014.10.024","article-title":"ESCMID\u2217 guideline for the diagnosis and treatment of biofilm infections 2014","volume":"21","author":"H\u00f8iby","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"2026110907070407900_cit51","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1146\/annurev.biochem.71.110601.135414","article-title":"Lipopolysaccharide Endotoxins","volume":"71","author":"Raetz","year":"2002","journal-title":"Annu. Rev. Biochem."},{"issue":"12","key":"2026110907070407900_cit52","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1039\/c4py01802h","article-title":"Synthesis of well-defined \u03b1,\u03c9-telechelic multiblock copolymers in aqueous medium: in situ generation of \u03b1,\u03c9-diols","volume":"6","author":"Simula","year":"2015","journal-title":"Polym. Chem."},{"issue":"19","key":"2026110907070407900_cit53","doi-asserted-by":"publisher","first-page":"8324","DOI":"10.1021\/acs.macromol.0c01083","article-title":"Understanding the Synthesis of Linear\u2013Bottlebrush\u2013Linear Block Copolymers: Toward Plastomers with Well-Defined Mechanical Properties","volume":"53","author":"Cong","year":"2020","journal-title":"Macromolecules"},{"issue":"4","key":"2026110907070407900_cit54","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1111\/j.1365-2958.2010.07267.x","article-title":"A bacterial extracellular DNA inhibits settling of motile progeny cells within a biofilm","volume":"77","author":"Berne","year":"2010","journal-title":"Mol. Microbiol."},{"issue":"4","key":"2026110907070407900_cit55","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"1","author":"Furman","year":"2021","journal-title":"Current Protocols"}],"container-title":["ACS Biomaterials Science &amp; Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.6c01161","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/abseba\/article-pdf\/12\/11\/6484\/68752196\/ab-2026-011612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/abseba\/article-pdf\/12\/11\/6484\/68752196\/ab-2026-011612.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T12:29:29Z","timestamp":1794227369000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/abseba\/article\/12\/11\/6484\/5444933\/A-Modular-Bottlebrush-Polymer-Platform-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":55,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,10,6]]},"published-print":{"date-parts":[[2026,11,9]]}},"URL":"https:\/\/doi.org\/10.1021\/acsbiomaterials.6c01161","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1021\/acsbiomaterials.6c01161.s001","asserted-by":"subject"}]},"ISSN":["2373-9878"],"issn-type":[{"value":"2373-9878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]}}}