{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:46:09Z","timestamp":1791794769059,"version":"4.3.4"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["FA9550-23-1-0253"],"award-info":[{"award-number":["FA9550-23-1-0253"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006686","name":"University of Miami","doi-asserted-by":"publisher","award":["UM-PRA-2025-5714"],"award-info":[{"award-number":["UM-PRA-2025-5714"]}],"id":[{"id":"10.13039\/100006686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Highly elastomeric materials are routinely found in nature that are generated from enzymatic cross-linking of proteins such as resilin. This process can be recreated on the benchtop using conventional photocatalytic approaches, which can be highly efficient; however, due to the large size of the elastomer generated via protein cross-linking, confirmation of the final structure remains elusive. Herein, we explore photocatalytic cross-linking of smaller resilin-like peptides (RLPs), taken from the resilin protein, which do not precipitate upon cross-linking. Using a [Ru(bpy)3]2+-based photocatalytic process, significant peptide degradation was observed, which dominated the reaction. Alternatively, enzymatic cross-linking of the peptides was observed to generate the anticipated product. Similar studies were conducted on a larger peptide construct where both the photocatalytic and enzymatic cross-linking process generated elastomeric materials with differing morphologies. AFM-based analysis confirmed vastly different Young\u2019s moduli based upon the cross-linking strategy. Computational modeling was used to predict likely molecular-level structures and mechanical properties of the elastomer materials based on both the photocatalytic and enzymatic preparation processes, indicating that the case where the rate of cross-linking is greater than that of chain fragmentation is the more likely photocatalytic scenario, based on the trends in predicted Young\u2019s modulus.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.6c01174","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:02:27Z","timestamp":1790712147000},"page":"5323-5332","source":"Crossref","is-referenced-by-count":0,"title":["Divergent Outcomes in Resilin-Like Peptide Cross-linking: Unexpected Photocatalytic Damage vs Enzymatic Success"],"prefix":"10.1021","volume":"12","author":[{"given":"Sradha M.","family":"Thomas","sequence":"first","affiliation":[{"name":"University of Miami , , , ,","place":["Coral Gables, Florida, United States, 33146"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0987-8122","authenticated-orcid":true,"given":"Che","family":"Zhang","sequence":"additional","affiliation":[{"name":"Deakin University , , , ,","place":["Geelong, Victoria, Australia, 3216"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1025-1191","authenticated-orcid":true,"given":"Haixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Miami , , , ,","place":["Coral Gables, Florida, United States, 33146"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-5765","authenticated-orcid":true,"given":"Yuxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Deakin University , , , ,","place":["Geelong, Victoria, Australia, 3216"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8383-4240","authenticated-orcid":true,"given":"Sanaz","family":"Farajollahi","sequence":"additional","affiliation":[{"name":"Wright-Patterson Air Force Base , , , ,","place":["Dayton, Ohio, United States, 45433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9336-2144","authenticated-orcid":true,"given":"Patrick M.","family":"Dennis","sequence":"additional","affiliation":[{"name":"Wright-Patterson Air Force Base , , , ,","place":["Dayton, Ohio, United States, 45433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Miami , , , ,","place":["Coral Gables, Florida, United States, 33146"]},{"name":"University of Miami , , , ,","place":["Coral Gables, Florida, United States, 33146"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7614-7258","authenticated-orcid":true,"given":"Marc R.","family":"Knecht","sequence":"additional","affiliation":[{"name":"University of Miami , , , ,","place":["Coral Gables, Florida, United States, 33146"]},{"name":"University of Miami , , , ,","place":["Miami, Florida, United States, 33136"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0233-9484","authenticated-orcid":true,"given":"Tiffany R.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Deakin University , , , ,","place":["Geelong, Victoria, Australia, 3216"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"5","key":"2026101202072072500_cit1","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1021\/acsbiomaterials.6b00469","article-title":"Biomechanical Design of Elastic Protein Biomaterials: A Balance of Protein Structure and Conformational Disorder","volume":"3","author":"Muiznieks","year":"2017","journal-title":"ACS Biomater. 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