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We report a Pd-catalyzed cyanide ion-free cyanation of aryl halides featuring a transmetallation potentially via halogen (X)-cyanide (CN\u2212) metathesis using potassium ferrocyanide as a bound CN\u2212 reservoir. Mechanistic studies, CN\u2212-sensing strip tests, and IR spectroscopy confirm that no free CN\u2013 is released at any stage, eliminating toxicity and downstream CN\u2212 liabilities. Stable AshPhos\u2212Pd nanoparticles formed within HPMC enable efficient cyanation across diverse (hetero)aryl bromides and chlorides under mild conditions. This approach likely combines process safety and environmental compliance, offering a scalable solution for late-stage CN\u2212 installation without the risks associated with free cyanide.<\/jats:p>","DOI":"10.1021\/acscatal.6c01639","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:17:37Z","timestamp":1778667457000},"page":"11324-11331","source":"Crossref","is-referenced-by-count":1,"title":["Transmetallation by Halogen-Cyanide Metathesis in Water: Application to Cyanide Ion-Free Palladium Catalyzed Cyanation"],"prefix":"10.1021","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2509-760X","authenticated-orcid":true,"given":"Ashish","family":"Dusunge","sequence":"first","affiliation":[{"name":"University of Missouri , , 601 S College Ave , , ,","place":["Columbia, Missouri, United States, 65211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh Hiralal","family":"Choudhary","sequence":"additional","affiliation":[{"name":"University of Missouri , , 601 S College Ave , , ,","place":["Columbia, Missouri, United States, 65211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1297-6145","authenticated-orcid":true,"given":"Jacek B.","family":"Jasinski","sequence":"additional","affiliation":[{"name":"University of Louisville , , , ,","place":["Louisville, Kentucky, United States, 40292"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried M.","family":"Braje","sequence":"additional","affiliation":[{"name":"AbbVie Deutschland GmbH & Co. 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