{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:44:50Z","timestamp":1780631090022,"version":"3.54.1"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2004102"],"award-info":[{"award-number":["2004102"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Purdue Drug Discovery Endowment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2021,9,17]]},"DOI":"10.1021\/acschembio.1c00342","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T18:33:00Z","timestamp":1630693980000},"page":"1663-1670","source":"Crossref","is-referenced-by-count":16,"title":["c-di-GMP Induces COX-2 Expression in Macrophages in a STING-Independent Manner"],"prefix":"10.1021","volume":"16","author":[{"given":"Modi","family":"Wang","sequence":"first","affiliation":[{"name":"Purdue Institute for Drug Discovery, West Lafayette, Indiana 47907, United States"},{"name":"Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riddhi","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Purdue Institute for Drug Discovery, West Lafayette, Indiana 47907, United States"},{"name":"Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson W. S.","family":"Ong","sequence":"additional","affiliation":[{"name":"Purdue Institute for Drug Discovery, West Lafayette, Indiana 47907, United States"},{"name":"Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-9359","authenticated-orcid":true,"given":"Herman O.","family":"Sintim","sequence":"additional","affiliation":[{"name":"Purdue Institute for Drug Discovery, West Lafayette, Indiana 47907, United States"},{"name":"Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States"},{"name":"Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,9,3]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.69.1.145"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00780.x"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf478"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.6.2317"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-7276-8_5"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevNeurobiol.v13.i1.30"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(20010201)49:2<176::AID-ANA37>3.0.CO;2-X"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27411"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.523"},{"key":"ref10\/cit10","first-page":"1061","volume":"64","author":"Rolland P. H.","year":"1980","journal-title":"J. Natl. Cancer Inst."},{"key":"ref11\/cit11","first-page":"4779","volume":"45","author":"Fulton A. M.","year":"1985","journal-title":"Cancer Res."},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf125"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704290"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/13.8.1013"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.4332"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00782-9"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1080\/10799893.2017.1360350"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2109"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.4.2171"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/nature10429"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232458"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2002144117"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00916-z"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1087-y"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1126\/science.369.6506.930-q"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-13-0123"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/C8MD00555A"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2886"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01413.x"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA04603D"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.01.009"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1006-9"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2152"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01082-08"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2757"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0251-z"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.014"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100088"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.190"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC03439J"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat1022"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.12.045"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.053"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1177\/1753425913507097"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.04.031"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0705-y"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1210\/me.2015-1027"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X0900676X"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.69"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00267"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.08.029"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706718"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.1c00342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T17:50:42Z","timestamp":1682617842000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.1c00342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,3]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9,17]]}},"alternative-id":["10.1021\/acschembio.1c00342"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.1c00342","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,3]]}}}