{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:43:12Z","timestamp":1791423792253,"version":"4.3.3"},"reference-count":25,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["210719"],"award-info":[{"award-number":["210719"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2023,11,17]]},"DOI":"10.1021\/acschembio.3c00491","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T22:23:05Z","timestamp":1697667785000},"page":"2430-2438","source":"Crossref","is-referenced-by-count":3,"title":["Mechanistic Analysis of Bioorthogonal Double Strain-Promoted Alkyne\u2013Nitrone Cycloadditions Involving Dibenzocyclooctadiyne"],"prefix":"10.1021","volume":"18","author":[{"given":"Didier A.","family":"Bilodeau","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of Ottawa, 150 Louis-Pasteur, Ottawa, Ontario, Canada K1N 6N5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn D.","family":"Margison","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of Ottawa, 150 Louis-Pasteur, Ottawa, Ontario, Canada K1N 6N5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi Sedghi","family":"Masoud","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of Ottawa, 150 Louis-Pasteur, Ottawa, Ontario, Canada K1N 6N5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-8945","authenticated-orcid":true,"given":"John Paul","family":"Pezacki","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of Ottawa, 150 Louis-Pasteur, Ottawa, Ontario, Canada K1N 6N5"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/9783527683451.ch14","volume-title":"Chemoselective and Bioorthogonal Ligation Reactions","author":"Gordon C. G.","year":"2017"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00832"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1295\/polymj.2.36"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/pol.1968.150060826"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/polc.5070160756"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202003386"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1039\/C9PY01362H"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.9b01609"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3765(20020503)8:9<2000::AID-CHEM2000>3.0.CO;2-B"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB01745C"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201808054"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b03459"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1039\/c0ob00003e"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1039\/c3ob00043e"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201000408"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc13808a"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2014.05.023"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/jo502248p"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201900627"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/c2ob07165g"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ja0734086"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00265"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA05092J"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00063"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.2c00569"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.3c00491","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.3c00491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T09:26:52Z","timestamp":1700213212000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.3c00491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11,17]]}},"alternative-id":["10.1021\/acschembio.3c00491"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.3c00491","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,18]]}}}