{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:41:55Z","timestamp":1793090515885,"version":"4.5.0"},"reference-count":26,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2024,11,15]]},"DOI":"10.1021\/acschembio.4c00571","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T19:18:01Z","timestamp":1729192681000},"page":"2372-2382","source":"Crossref","is-referenced-by-count":12,"title":["Novel Corrector for Variants of SLC6A8: A Therapeutic Opportunity for Creatine Transporter Deficiency"],"prefix":"10.1021","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3226-5778","authenticated-orcid":true,"given":"Lara N.","family":"Gechijian","sequence":"first","affiliation":[{"name":"Jnana Therapeutics, Boston, Massachusetts 02210, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Muncipinto","sequence":"additional","affiliation":[{"name":"Third Harmonic Bio, Cambridge, Massachusetts 02139, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Justin","family":"Rettenmaier","sequence":"additional","affiliation":[{"name":"Jnana Therapeutics, Boston, Massachusetts 02210, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Labenski","sequence":"additional","affiliation":[{"name":"Jnana Therapeutics, Boston, Massachusetts 02210, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Rusu","sequence":"additional","affiliation":[{"name":"Apple Tree Partners, New York, New York 10169, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Rosskamp","sequence":"additional","affiliation":[{"name":"Jnana Therapeutics, Boston, Massachusetts 02210, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Conway","sequence":"additional","affiliation":[{"name":"Jnana Therapeutics, Boston, Massachusetts 02210, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"van Kalken","sequence":"additional","affiliation":[{"name":"Jnana Therapeutics, Boston, Massachusetts 02210, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Gross","sequence":"additional","affiliation":[{"name":"Oregon State University, Portland, Oregon 97331, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna","family":"Iantosca","sequence":"additional","affiliation":[{"name":"Atavistik Bio, Cambridge, Massachusetts 02140, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8199-5959","authenticated-orcid":true,"given":"William","family":"Crotty","sequence":"additional","affiliation":[{"name":"Neumora Tx, Watertown, Massachusetts 02472, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Mathis","sequence":"additional","affiliation":[{"name":"Jnana Therapeutics, Boston, Massachusetts 02210, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyejin","family":"Park","sequence":"additional","affiliation":[{"name":"Jnana Therapeutics, Boston, Massachusetts 02210, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Rabin","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Westgate","sequence":"additional","affiliation":[{"name":"DG Medicines, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1207-9671","authenticated-orcid":true,"given":"Matthew","family":"Lyons","sequence":"additional","affiliation":[{"name":"University of California, San Francisco, California 90095, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Deshusses","sequence":"additional","affiliation":[{"name":"University of North Carolina, Chapel Hill, North Carolina 27599, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Brandon","sequence":"additional","affiliation":[{"name":"Neumora Tx, Watertown, Massachusetts 02472, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-3928","authenticated-orcid":true,"given":"Dean G.","family":"Brown","sequence":"additional","affiliation":[{"name":"Jnana Therapeutics, Boston, Massachusetts 02210, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather S.","family":"Blanchette","sequence":"additional","affiliation":[{"name":"Jnana Therapeutics, Boston, Massachusetts 02210, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Pullen","sequence":"additional","affiliation":[{"name":"ArtBio, Cambridge, Massachusetts 02139, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8388-5865","authenticated-orcid":true,"given":"Lyn H.","family":"Jones","sequence":"additional","affiliation":[{"name":"Center for Protein Degradation, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02215, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel C.","family":"Barrish","sequence":"additional","affiliation":[{"name":"RA Capital Ventures, Boston, Massachusetts 02116, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1908639"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00169.2005"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105787108"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-006-0162-9"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1086\/323765"},{"key":"ref6\/cit6","first-page":"1897","volume-title":"The Metabolic and Molecular Basis of Inherited Disease","author":"Von Figura K.","year":"2001","edition":"8"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2010.01460.x"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.79"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(96)04116-5"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101658"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34208"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b16-00582"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21438"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1086\/320595"},{"key":"ref15\/cit15","first-page":"249","volume-title":"Targeting Trafficking in Drug Development","author":"Freissmuth M.","year":"2018"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.12.022"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0271-6"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.9b00956"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20532"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.03.015"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1177\/1087057108321531"},{"key":"ref22\/cit22","unstructured":"Labenski, M. T., Rettenmaier, T., Jones, L., Muncipinto, G. Reactive affinity probe-interaction discovery platform. WO 2021076680 A1, 2021. https:\/\/patents.google.com\/patent\/WO2021076680A1\/en."},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1159\/000111450"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/4801"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-013-9619-x"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016187"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.4c00571","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.4c00571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T09:32:42Z","timestamp":1731663162000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.4c00571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11,15]]}},"alternative-id":["10.1021\/acschembio.4c00571"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.4c00571","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,17]]}}}