{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T08:28:11Z","timestamp":1793608091015,"version":"4.5.0"},"reference-count":118,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2025,1,17]]},"DOI":"10.1021\/acschembio.4c00608","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T22:45:26Z","timestamp":1735339526000},"page":"19-32","source":"Crossref","is-referenced-by-count":22,"title":["Click Chemistry Methodology: The Novel Paintbrush of Drug Design"],"prefix":"10.1021","volume":"20","author":[{"given":"Ioana","family":"Oprea","sequence":"first","affiliation":[{"name":"Biomedical Science Research Complex, Schools of Biology and Chemistry, University of Saint Andrews, North Haugh, St Andrews KY16 9ST, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1994-2009","authenticated-orcid":true,"given":"Terry K.","family":"Smith","sequence":"additional","affiliation":[{"name":"Biomedical Science Research Complex, Schools of Biology and Chemistry, University of Saint Andrews, North Haugh, St Andrews KY16 9ST, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/jo011148j"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5460.2007"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.10.034"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/bc700300f"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/ol0610946"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.106"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201903909"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201807497"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200903233"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566069"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5315.1125"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nbt765"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200705805"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.4c00084"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.trechm.2019.08.003"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ja044996f"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707090104"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/ol801141k"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201000419"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00184C"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/ar200037t"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/ja8053805"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906294"},{"key":"ref25\/ref25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0PY00375A"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202207640"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201309399"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909972116"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201200531"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/cb5009475"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/9780470559277.ch090167"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2022.116819"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/C0SC00373E"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1186\/s12953-017-0123-3"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/bip.21010"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297907010014"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3390\/molecules180910425"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20082"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2008.07.156"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA03538E"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.06.048"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/cr1002722"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2008.11.009"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201108130"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b02383"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/ja0302836"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00789"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/0958-1669(93)90072-5"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(03)00110-6"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.211"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200400656"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/ja015873n"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/ja00205a033"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.932"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/srep10916"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2013.02.001"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.04.019"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.9b00113"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2020.151889"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.12.2430"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.5b00198"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201503652"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/jo401780u"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.5b00668"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2021.116508"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200905087"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201101817"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201902489"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1039\/D2MD00197G"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.148"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2016.0657"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2017.0665"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1021\/jo400651k"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2019.130914"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200800441"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1039\/C3SC51753E"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB00007J"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC05159J"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1021\/ol0610946"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/14.18.7391"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201801757"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200790055"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200890131"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b01533"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1021\/ja3026714"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc14316f"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201307628"},{"issue":"12","key":"ref88\/cit88","first-page":"3402","volume":"52","author":"Yokota D. E.","year":"1992","journal-title":"Cancer Res."},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1230"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00750"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100042200"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)92882-6"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1007\/s12154-009-0032-8"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01280-07"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00751"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1042\/BST20140281"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-0388-4"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.2174\/156800912801784857"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182017000282"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1039\/B716115H"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.65.070196.001325"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.16.6105-6113.2000"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1039\/C2MD20299A"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201505964"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113193109"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25071515"},{"key":"ref107\/cit107","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-1-4939-9654-4_14","volume-title":"Bioconjugation: Methods and Protocols","author":"Zhang Y.","year":"2019"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.7b00633"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC06083F"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201800269"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC01334K"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.3c00286"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2022.2040987"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00335-7"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-023-01433-6"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01280-4"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-849802"},{"issue":"5","key":"ref118\/cit118","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.3390\/curroncol29050247","volume":"29","author":"Shiravand Y.","year":"2022","journal-title":"Curr. Oncol."}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.4c00608","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.4c00608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T06:22:06Z","timestamp":1740464526000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.4c00608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":118,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,17]]}},"alternative-id":["10.1021\/acschembio.4c00608"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.4c00608","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,27]]}}}