{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:34:37Z","timestamp":1772735677371,"version":"3.50.1"},"reference-count":81,"publisher":"American Chemical Society (ACS)","issue":"6","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 1069"],"award-info":[{"award-number":["EXC 1069"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1093"],"award-info":[{"award-number":["SFB1093"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007215","name":"Verband der Chemischen Industrie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007215","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jim Easton Consortium for Alzheimer\u2019s Drug Discovery and Biomarker Development, University of California, Los Angeles"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2015,6,19]]},"DOI":"10.1021\/acschembio.5b00146","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T15:21:16Z","timestamp":1428333676000},"page":"1555-1569","source":"Crossref","is-referenced-by-count":49,"title":["Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism"],"prefix":"10.1021","volume":"10","author":[{"given":"Dahabada H. J.","family":"Lopes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Attar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayatri","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric Y.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenming","family":"Du","sequence":"additional","affiliation":[{"name":"Department\rof Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"McDaniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Som","family":"Dutt","sequence":"additional","affiliation":[{"name":"Institute\rof Organic Chemistry, University of Duisburg-Essen, 45141 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Bandmann","sequence":"additional","affiliation":[{"name":"Institute\rof Organic Chemistry, University of Duisburg-Essen, 45141 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenny","family":"Bravo-Rodriguez","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Kohlenforschung, 45470 M\u00fclheim an der Ruhr, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit","family":"Mittal","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Kohlenforschung, 45470 M\u00fclheim an der Ruhr, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank-Gerrit","family":"Kl\u00e4rner","sequence":"additional","affiliation":[{"name":"Institute\rof Organic Chemistry, University of Duisburg-Essen, 45141 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department\rof Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Sanchez-Garcia","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Kohlenforschung, 45470 M\u00fclheim an der Ruhr, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Schrader","sequence":"additional","affiliation":[{"name":"Institute\rof Organic Chemistry, University of Duisburg-Essen, 45141 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gal","family":"Bitan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"ref1\/cit1","first-page":"131","volume":"14","author":"Tunis S. L.","year":"2008","journal-title":"Am. J. Manag. Care"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.2337\/diacare.29.s1.06.s43","volume":"29","author":"American Diabetes Association (ADA)","year":"2006","journal-title":"Diabetes Care"},{"key":"ref3\/cit3","first-page":"93","volume":"80","author":"Rossi M. C.","year":"2009","journal-title":"Acta Biomed."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"917","DOI":"10.2337\/diacare.26.3.917","volume":"26","author":"Hogan P.","year":"2003","journal-title":"Diabetes Care"},{"key":"ref5\/cit5","first-page":"414","volume":"127","author":"Westermark P.","year":"1987","journal-title":"Am. J. Pathol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/1097-0282(2001)60:6<438::AID-BIP10182>3.0.CO;2-A","volume":"60","author":"Kapurniotu A.","year":"2001","journal-title":"Biopolymers"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0165-6147(93)90081-T","volume":"14","author":"Rink T. J.","year":"1993","journal-title":"Trends Pharmacol. Sci."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"9496","DOI":"10.1021\/bi060579z","volume":"45","author":"Knight J. D.","year":"2006","journal-title":"Biochemistry"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jmb.2009.07.077","volume":"393","author":"Williamson J. A.","year":"2009","journal-title":"J. Mol. Biol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"18283","DOI":"10.1021\/ja903814q","volume":"131","author":"Dupuis N. F.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1073\/pnas.87.13.5036","volume":"87","author":"Westermark P.","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-94-007-2774-8_7","volume-title":"Pre-fibrillar amyloidogenic protein assemblies\u2014common cytotoxins underlying degenerative diseases","author":"Degaki T. L.","year":"2012"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"13505","DOI":"10.1021\/bi701427q","volume":"46","author":"Luca S.","year":"2007","journal-title":"Biochemistry"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1016\/j.bpj.2010.07.014","volume":"99","author":"Reddy A. S.","year":"2010","journal-title":"Biophys. J."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"16066","DOI":"10.1021\/jp409755y","volume":"117","author":"Miller C.","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bpc.2012.03.010","volume":"167","author":"Murphy R. D.","year":"2012","journal-title":"Biophys. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1021\/ja1081537","volume":"133","author":"Dupuis N. F.","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1021\/jp108870q","volume":"115","author":"Laghaei R.","year":"2011","journal-title":"J. Phys. Chem. B"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"16092","DOI":"10.1021\/ja403147m","volume":"135","author":"Qiao Q.","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"3","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1042\/bj3220859","volume":"322","author":"Tomiyama T.","year":"1997","journal-title":"Biochem. J."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/368756a0","volume":"368","author":"Lorenzo A.","year":"1994","journal-title":"Nature"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1042\/bj20030422","volume":"374","author":"Aitken J. F.","year":"2003","journal-title":"Biochem. J."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0014-5793(01)02972-6","volume":"507","author":"Harroun T. A.","year":"2001","journal-title":"FEBS Lett."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1021\/bi800043d","volume":"47","author":"Levy M.","year":"2008","journal-title":"Biochemistry"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/pro.2518","volume":"23","author":"Hebda J. A.","year":"2014","journal-title":"Protein Sci."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1073\/pnas.0507471103","volume":"103","author":"Yan L. M.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jmb.2010.05.001","volume":"400","author":"Meng F.","year":"2010","journal-title":"J. Mol. Biol."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0022-2836(02)00164-X","volume":"318","author":"Scrocchi L. A.","year":"2002","journal-title":"J. Mol. Biol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/anie.200901694","volume":"49","author":"Saraogi I.","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"16958","DOI":"10.1021\/ja206279b","volume":"133","author":"Sinha S.","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"10727","DOI":"10.1074\/jbc.M113.524520","volume":"289","author":"Acharya S.","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"12086","DOI":"10.1021\/ja035212l","volume":"125","author":"Molt O.","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"14415","DOI":"10.1021\/ja052806a","volume":"127","author":"Fokkens M.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1021\/ja058410g","volume":"128","author":"Kl\u00e4rner F. G.","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.1021\/bi702518m","volume":"47","author":"Meng F.","year":"2008","journal-title":"Biochemistry"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s13311-012-0105-1","volume":"9","author":"Prabhudesai S.","year":"2012","journal-title":"Neurotherapeutics"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1021\/bi800828u","volume":"47","author":"Yonemoto I. T.","year":"2008","journal-title":"Biochemistry"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.chembiol.2005.05.010","volume":"12","author":"Tatarek-Nossol M.","year":"2005","journal-title":"Chem. Biol."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1021\/acs.jpcb.5b00692","volume":"119","author":"Zheng X.","year":"2015","journal-title":"J. Phys. Chem B."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.brainresbull.2003.09.011","volume":"62","author":"Datki Z.","year":"2003","journal-title":"Brain Res. Bull."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/cbir.2000.0643","volume":"25","author":"Saafi E. L.","year":"2001","journal-title":"Cell Biol. Int."},{"key":"ref42\/cit42","first-page":"289","volume":"5","author":"Duke R. C.","year":"1986","journal-title":"Lymphokine Res."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nchem.1570","volume":"5","author":"Bier D.","year":"2013","journal-title":"Nat. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"11982","DOI":"10.1074\/jbc.M809085200","volume":"284","author":"Patil S. M.","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1016\/j.bbamem.2011.06.012","volume":"1808","author":"Nanga R. P.","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"9824","DOI":"10.1021\/ja801441j","volume":"130","author":"Talbiersky P.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.1002\/ejoc.201301211","volume":"2013","author":"Dutt S.","year":"2013","journal-title":"Eur. J. Org. Chem."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.bbrc.2012.05.013","volume":"422","author":"Sparks S.","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.chembiol.2014.05.007","volume":"21","author":"Kumar S.","year":"2014","journal-title":"Chem. Biol."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1039\/c3cc41452c","volume":"49","author":"Kumar S.","year":"2013","journal-title":"Chem. Commun. (Cambridge, England)"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"18223","DOI":"10.1021\/ja1069882","volume":"132","author":"Liu G.","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref52\/cit52","first-page":"205","volume":"350","author":"Zhou R.","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"752","DOI":"10.2337\/diab.39.6.752","volume":"39","author":"Butler P. C.","year":"1990","journal-title":"Diabetes"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1172\/JCI114528","volume":"85","author":"Ogawa A.","year":"1990","journal-title":"J. Clin. Invest."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"R1475","DOI":"10.1152\/ajpregu.00703.2009","volume":"298","author":"Lutz T. A.","year":"2010","journal-title":"Am. J. Physiol Regul. Integr. Comp. Physiol."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/0024-3205(93)90480-Q","volume":"52","author":"Young A. A.","year":"1993","journal-title":"Life Sci."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s13311-013-0256-8","volume":"11","author":"Ferreira N.","year":"2014","journal-title":"Neurotherapeutics"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/2050-6511-15-23","volume":"15","author":"Attar A.","year":"2014","journal-title":"BMC Pharmacol. Toxicol."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1021\/cn200133x","volume":"3","author":"Sinha S.","year":"2012","journal-title":"ACS Chem. Neurosci."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1093\/brain\/aws289","volume":"135","author":"Attar A.","year":"2012","journal-title":"Brain"},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1021\/cn3000247","volume":"3","author":"Sinha S.","year":"2012","journal-title":"ACS Chem. Neurosci."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.2174\/13816128113199990496","volume":"20","author":"Attar A.","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0092-8674(93)90635-4","volume":"73","author":"Jarrett J. T.","year":"1993","journal-title":"Cell"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1126\/science.1222951","volume":"336","author":"Prusiner S. B.","year":"2012","journal-title":"Science"},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-1-61779-551-0_2","volume":"849","author":"Lopes D. H.","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"e7694","DOI":"10.1371\/journal.pone.0007694","volume":"4","author":"Rahimi F.","year":"2009","journal-title":"PLoS One"},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1042\/BJ20101391","volume":"433","author":"Maiti P.","year":"2010","journal-title":"Biochem. J."},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1196\/annals.1299.114","volume":"1010","author":"Corsaro A.","year":"2003","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/jcc.20065","volume":"25","author":"Mackerell A. D.","year":"2004","journal-title":"J. Comput. Chem."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1002\/jcc.21816","volume":"32","author":"Zoete V.","year":"2011","journal-title":"J. Comput. Chem."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1021\/jo4009673","volume":"78","author":"Dutt S.","year":"2013","journal-title":"J. Org. Chem."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ct700301q","volume":"4","author":"Hess B.","year":"2008","journal-title":"J. Chem. Theory Comput"},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"Jorgensen W. L.","year":"1983","journal-title":"J. Chem. Phys."},{"key":"ref74\/cit74","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1063\/1.469273","volume":"102","author":"Tironi I. G.","year":"1995","journal-title":"J. Chem. Phys."},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","volume":"18","author":"Hess B.","year":"1997","journal-title":"J. Comput. Chem."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","volume":"98","author":"Darden T.","year":"1993","journal-title":"J. Chem. Phys."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1063\/1.470117","volume":"103","author":"Essmann U.","year":"1995","journal-title":"J. Chem. Phys."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1039\/b716554d","volume":"10","author":"Patriksson A.","year":"2008","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0009-2614(01)00055-0","volume":"335","author":"Okabe T.","year":"2001","journal-title":"Chem. Phys. Lett."},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1143\/JPSJ.65.1604","volume":"65","author":"Hukushima K.","year":"1996","journal-title":"J. Phys. Soc. Jpn."},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/(SICI)1521-3773(19990115)38:1\/2<236::AID-ANIE236>3.0.CO;2-M","volume":"38","author":"Daura X.","year":"1999","journal-title":"Angew. Chem., Int. Ed."}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.5b00146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T11:26:48Z","timestamp":1681471608000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.5b00146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,16]]},"references-count":81,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6,19]]}},"alternative-id":["10.1021\/acschembio.5b00146"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.5b00146","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,16]]}}}