{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:57:42Z","timestamp":1789408662037,"version":"build-2803163510"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"9","funder":[{"DOI":"10.13039\/100001605","name":"Epilepsy Foundation","doi-asserted-by":"publisher","award":["225243"],"award-info":[{"award-number":["225243"]}],"id":[{"id":"10.13039\/100001605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008564","name":"School of Medicine, Case Western Reserve University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008564","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK53307"],"award-info":[{"award-number":["R01 DK53307"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL007567"],"award-info":[{"award-number":["T32 HL007567"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2015,9,18]]},"DOI":"10.1021\/acschembio.5b00479","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T18:52:09Z","timestamp":1436813529000},"page":"2135-2148","source":"Crossref","is-referenced-by-count":36,"title":["L-type Calcium Channel Blockers Enhance Trafficking and Function of Epilepsy-associated \u03b11(D219N) Subunits of GABA<sub>A<\/sub> Receptors"],"prefix":"10.1021","volume":"10","author":[{"given":"Dong-Yun","family":"Han","sequence":"first","affiliation":[{"name":"Department\rof Physiology and Biophysics, \u2021Department of Pharmacology, \u00a7Center for Proteomics\rand Bioinformatics and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Jhih","family":"Guan","sequence":"additional","affiliation":[{"name":"Department\rof Physiology and Biophysics, \u2021Department of Pharmacology, \u00a7Center for Proteomics\rand Bioinformatics and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department\rof Physiology and Biophysics, \u2021Department of Pharmacology, \u00a7Center for Proteomics\rand Bioinformatics and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hatzoglou","sequence":"additional","affiliation":[{"name":"Department\rof Physiology and Biophysics, \u2021Department of Pharmacology, \u00a7Center for Proteomics\rand Bioinformatics and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Wei","family":"Mu","sequence":"additional","affiliation":[{"name":"Department\rof Physiology and Biophysics, \u2021Department of Pharmacology, \u00a7Center for Proteomics\rand Bioinformatics and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2011"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013185"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209235"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141448"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.05.003"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.013474"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.763"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-3209-8_83"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.275"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060026"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.368"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10222"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004641"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.043"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/pr400535z"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nature12439"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.186999"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.26.010302.081210"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/cr300044d"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1124\/mol.115.097998"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.17.030194.003033"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.06.002"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2010"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/ng885"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07767.x"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(04)00109-2"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/nature13293"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508305200"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.09.020"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.580324"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1523\/JNEUROSCI.17-17-06587.1997","volume":"17","author":"Gorrie G. H.","year":"1997","journal-title":"J. Neurosci."},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.05.030"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.01.005"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413111111"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.04.002"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.10.012"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2009.02.014"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.543215"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801708200"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301420200"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/jm900036m"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.570200"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1385\/MN:26:2-3:251"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.1.89"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9899"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1126\/science.2551039"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.04.015"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2320-10.2010"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(90)82392-4"},{"key":"ref51\/cit51","first-page":"F96","volume":"28","author":"Coe H.","year":"2009","journal-title":"Gen. Physiol. Biophys."},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00494-5"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02856"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90395-X"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-1849-1"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003120"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801046200"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.5b00479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T23:08:34Z","timestamp":1681600114000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.5b00479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,21]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9,18]]}},"alternative-id":["10.1021\/acschembio.5b00479"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.5b00479","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,21]]}}}