{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:10:03Z","timestamp":1790651403755,"version":"4.1.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"11","funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM098254"],"award-info":[{"award-number":["GM098254"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM71896"],"award-info":[{"award-number":["GM71896"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-57684"],"award-info":[{"award-number":["MOP-57684"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-81294"],"award-info":[{"award-number":["MOP-81294"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2015,11,20]]},"DOI":"10.1021\/acschembio.5b00612","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T20:23:21Z","timestamp":1441830201000},"page":"2616-2623","source":"Crossref","is-referenced-by-count":46,"title":["Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic Inference"],"prefix":"10.1021","volume":"10","author":[{"given":"Sheila M.","family":"Pimentel-Elardo","sequence":"first","affiliation":[{"name":"Department\rof Biochemistry, Medical Sciences Building, University of Toronto, 1 King\u2019s College Circle, Toronto, Ontario M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry and Chemical Biology, McMaster University, 1280 Main\rSt. West, Hamilton, Ontario L8S 4M1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Ho","sequence":"additional","affiliation":[{"name":"Department\rof Biochemistry, Medical Sciences Building, University of Toronto, 1 King\u2019s College Circle, Toronto, Ontario M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikaela","family":"Ziko","sequence":"additional","affiliation":[{"name":"Department\rof Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St. West, Hamilton, Ontario L8S 4M1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Bueler","sequence":"additional","affiliation":[{"name":"Molecular Structure & Function Program, The Hospital for Sick Children Research Institute, 686 Bay St., Toronto, Ontario M5G 0A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Lu","sequence":"additional","affiliation":[{"name":"Keenan\rResearch Centre for Biomedical Sciences, St. Michael\u2019s Hospital, 30 Bond St., Toronto, Ontario M5B 1W8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Biophysics, University of California at San Francisco, Mission Bay, Genentech Hall 600 16th St., San Francisco, California 94158-2517, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvin","family":"Moser","sequence":"additional","affiliation":[{"name":"Advanced Chemistry Development Inc., 8 King St. East, Suite 107, Toronto, Ontario M5C 1B5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lee","sequence":"additional","affiliation":[{"name":"Advanced Chemistry Development Inc., 8 King St. East, Suite 107, Toronto, Ontario M5C 1B5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Agard","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Biophysics, University of California at San Francisco, Mission Bay, Genentech Hall 600 16th St., San Francisco, California 94158-2517, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Fairn","sequence":"additional","affiliation":[{"name":"Keenan\rResearch Centre for Biomedical Sciences, St. Michael\u2019s Hospital, 30 Bond St., Toronto, Ontario M5B 1W8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"Department\rof Biochemistry, Medical Sciences Building, University of Toronto, 1 King\u2019s College Circle, Toronto, Ontario M5S 1A8, Canada"},{"name":"Molecular Structure & Function Program, The Hospital for Sick Children Research Institute, 686 Bay St., Toronto, Ontario M5G 0A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Shoichet","sequence":"additional","affiliation":[{"name":"Department\rof Pharmaceutical Chemistry, University of California, San Francisco, 1700 4th St., Byers Hall Suite 508D, San Francisco California 94158-2550, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin R.","family":"Nodwell","sequence":"additional","affiliation":[{"name":"Department\rof Biochemistry, Medical Sciences Building, University of Toronto, 1 King\u2019s College Circle, Toronto, Ontario M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2005.1"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.11.001"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-005-0077-9"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2014.12"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/b817069j"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt449"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019077108"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1538"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108124108"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-013-1387-y"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2013.25"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2010.13"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-013-1348-5"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1240"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1534"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.06.013"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2685"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2011.59"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.29161-0"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201200619"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.49.2509"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.27.206"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/BF02884062"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1977.360160112"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.12.023"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.070508"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.119.4.773"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.21.15284"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.11.1.305"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1284"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1228"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/ci600197y"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2095"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/cb500393m"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1338"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1031"},{"key":"ref37\/cit37","volume-title":"Chemoinformatics in Drug Discovery","author":"Olah M.","year":"2005"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/ci8000259"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/nature08506"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/jm901613f"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.732"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/nature11159"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001712"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324161111"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/c3np70111e"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-395"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-4-5"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq537"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2422"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/bi00313a018"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.5b00612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T23:00:48Z","timestamp":1681599648000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.5b00612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,18]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11,20]]}},"alternative-id":["10.1021\/acschembio.5b00612"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.5b00612","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,18]]}}}