{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:28:08Z","timestamp":1778254088741,"version":"3.51.4"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"5","funder":[{"DOI":"10.13039\/501100000032","name":"Institute of Infection and Immunity","doi-asserted-by":"publisher","award":["MOP-114889"],"award-info":[{"award-number":["MOP-114889"]}],"id":[{"id":"10.13039\/501100000032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2016,5,20]]},"DOI":"10.1021\/acschembio.5b01070","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T20:56:22Z","timestamp":1456174582000},"page":"1339-1346","source":"Crossref","is-referenced-by-count":24,"title":["Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design"],"prefix":"10.1021","volume":"11","author":[{"given":"Angelia V.","family":"Bassenden","sequence":"first","affiliation":[{"name":"Department\rof Biochemistry, McGill University, McIntyre Medical Building, 3655\rPromenade Sir William Osler, Montreal, Quebec, Canada, H3G 1Y6"},{"name":"Groupe\rde Recherche Ax\u00e9 sur la Structure des Prot\u00e9ines, McGill University, Bellini Pavilion, 3649 Promenade Sir William Osler, Montreal, Quebec, Canada, H3G 0B1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Rodionov","sequence":"additional","affiliation":[{"name":"Department\rof Biochemistry, McGill University, McIntyre Medical Building, 3655\rPromenade Sir William Osler, Montreal, Quebec, Canada, H3G 1Y6"},{"name":"Groupe\rde Recherche Ax\u00e9 sur la Structure des Prot\u00e9ines, McGill University, Bellini Pavilion, 3649 Promenade Sir William Osler, Montreal, Quebec, Canada, H3G 0B1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department\rof Biochemistry, McGill University, McIntyre Medical Building, 3655\rPromenade Sir William Osler, Montreal, Quebec, Canada, H3G 1Y6"},{"name":"Groupe\rde Recherche Ax\u00e9 sur la Structure des Prot\u00e9ines, McGill University, Bellini Pavilion, 3649 Promenade Sir William Osler, Montreal, Quebec, Canada, H3G 0B1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert M.","family":"Berghuis","sequence":"additional","affiliation":[{"name":"Department\rof Biochemistry, McGill University, McIntyre Medical Building, 3655\rPromenade Sir William Osler, Montreal, Quebec, Canada, H3G 1Y6"},{"name":"Department\rof Microbiology and Immunology, McGill University, Duff Medical Building, 3775 University\rStreet, Montreal, Quebec, Canada, H3A 2B4"},{"name":"Groupe\rde Recherche Ax\u00e9 sur la Structure des Prot\u00e9ines, McGill University, Bellini Pavilion, 3649 Promenade Sir William Osler, Montreal, Quebec, Canada, H3G 0B1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.08.003"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/cb3005116"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.337"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1204073109"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32833eebfd"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1128\/mr.57.1.138-163.1993","volume":"57","author":"Shaw K.-J.","year":"1993","journal-title":"Microbiol. Rev."},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/bi200747f"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00149-09"},{"key":"ref9\/cit9","unstructured":"Stogios, P.J., Evdokimova, E., Minasov, G., Yim, V., Courvalin, P., Savchenko, A., and Anderson, W.F., and Center for Structural Genomics of Infections Disease. RCSB: Protein Data Bank.http:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=4evy(accessed December 3 2015) . Crystal structure of aminoglycoside antibiotic 6\u2032-N-acetytransferase AAC(6\u2032)-Ig from Acinetobacter haemolyticus in complex with tobramycin."},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.28.2.282"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/bi00410a045"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02180-14"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/bi00041a005"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1039\/C5MD00384A"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1086\/313949"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.01.006"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki347"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(02)00153-9"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki862"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.10.2323"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s101560050001"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/135.Supplement_2.S242"},{"key":"ref23\/cit23","first-page":"1026","volume":"113","author":"Zhoa C.","year":"2000","journal-title":"Chin. Med. J."},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2010.09.004"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00572-10"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/bi002827b"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2005.01.016"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-246-5_20"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1107\/S090744499900935X"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889809045701"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444994003112"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444905036693"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909047337"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909052925"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910007493"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889811041768"},{"key":"ref38\/cit38","unstructured":"Grade Web Server.http:\/\/grade.globalphasing.org\/(accessed December 3 2015) .Global Phasing Limited."}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.5b01070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T07:57:35Z","timestamp":1682236655000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.5b01070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,4]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5,20]]}},"alternative-id":["10.1021\/acschembio.5b01070"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.5b01070","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,4]]}}}