{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:08:02Z","timestamp":1778836082263,"version":"3.51.4"},"reference-count":86,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA0913200"],"award-info":[{"award-number":["2022YFA0913200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005145","name":"Basic Research Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20250150"],"award-info":[{"award-number":["BK20250150"]}],"id":[{"id":"10.13039\/501100005145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177085"],"award-info":[{"award-number":["22177085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477092"],"award-info":[{"award-number":["22477092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases"},{"name":"Suzhou Medical College of Soochow University","award":["YXY2302015"],"award-info":[{"award-number":["YXY2302015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2026,5,15]]},"DOI":"10.1021\/acschembio.6c00132","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:02:57Z","timestamp":1775912577000},"page":"1146-1157","source":"Crossref","is-referenced-by-count":0,"title":["Expedient Chemical Synthesis of Ufmylated Histones Using Chemoenzymatic C-Terminal Hydrazinolysis of Ubiquitin-Fold Modifier 1"],"prefix":"10.1021","volume":"21","author":[{"given":"Xin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemistry and the First Affiliated Hospital of USTC, School of Life Sciences and School of Biomedical Engineering, Division of Life Sciences and Medicine, Joint Center for Biological Analytical Chemistry, Anhui Laboratory of Advanced Photonic Science and Technology","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Suzhou Key Laboratory of Drug Research for Prevention and Treatment of Hyperlipidemic Diseases","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy","place":["Suzhou, China"]},{"name":"The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Suzhou Key Laboratory of Drug Research for Prevention and Treatment of Hyperlipidemic Diseases","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengpiao","family":"Lu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Suzhou Key Laboratory of Drug Research for Prevention and Treatment of Hyperlipidemic Diseases","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Suzhou Key Laboratory of Drug Research for Prevention and Treatment of Hyperlipidemic Diseases","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Peng","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Suzhou Key Laboratory of Drug Research for Prevention and Treatment of Hyperlipidemic Diseases","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]},{"name":"Suzhou Key Laboratory of Geriatric Neurological Disorders, the First People\u2019s Hospital of Taicang","place":["Suzhou, China"]},{"name":"Taicang Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongrui","family":"Xu","sequence":"additional","affiliation":[{"name":"Suzhou Municipal Center for Disease Control and Prevention","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9315-900X","authenticated-orcid":true,"given":"Changlin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Chemistry and the First Affiliated Hospital of USTC, School of Life Sciences and School of Biomedical Engineering, Division of Life Sciences and Medicine, Joint Center for Biological Analytical Chemistry, Anhui Laboratory of Advanced Photonic Science and Technology","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4753-4769","authenticated-orcid":true,"given":"Guoqiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Suzhou Key Laboratory of Drug Research for Prevention and Treatment of Hyperlipidemic Diseases","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]},{"name":"Suzhou Key Laboratory of Geriatric Neurological Disorders, the First People\u2019s Hospital of Taicang","place":["Suzhou, China"]},{"name":"Taicang Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-5787","authenticated-orcid":true,"given":"Jia-Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Suzhou Key Laboratory of Drug Research for Prevention and Treatment of Hyperlipidemic Diseases","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-022-00468-7"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2020.11.005"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax8214"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09175-0"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-025-00944-y"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.11.034"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC03664B"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-024-01342-2"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201600638"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-024-2860-5"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.4c00642"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-024-1950-1"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201800432"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201204144"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03148-5"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201809232"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202300414"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00252"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.2c00203"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c20510"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05628-0"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC00681D"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.157"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC01721A"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201600551"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201503309"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201303844"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1039\/C5OB02323H"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ja308908p"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/cb9002255"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nature06906"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202413651"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2023.01.012"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC00332A"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c06156"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23636-5"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC05526F"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b13213"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b03572"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/psc.2976"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504483112"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2014.07.006"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.315"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00716"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC06683A"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-025-01985-2"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-025-2697-6"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu1864"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-024-01750-x"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-023-01141-1"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05841-y"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.08.001"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01067-7"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc3393"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03716-8"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03776-w"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04097-8"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6663"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.019.20190001"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2235"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10589"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.501"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00712"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201100996"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201203843"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.152"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c10091"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.023.202303397"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111168"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102016"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b00140"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2021.153383"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202002974"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201300608"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-019-0211-7"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202502884"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c13464"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200704195"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-019-9513-2"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1038\/38444"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.05.143"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.172171"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708756200"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12951"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.11.038"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf7586"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.6c00132","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.6c00132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:13:38Z","timestamp":1778832818000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.6c00132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,11]]},"references-count":86,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,15]]}},"alternative-id":["10.1021\/acschembio.6c00132"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.6c00132","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,11]]}}}