{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:52:53Z","timestamp":1781859173115,"version":"3.54.5"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["FT2023-0013"],"award-info":[{"award-number":["FT2023-0013"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["PR2022-0084"],"award-info":[{"award-number":["PR2022-0084"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["PR2023-0082"],"award-info":[{"award-number":["PR2023-0082"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["ST2015-0008"],"award-info":[{"award-number":["ST2015-0008"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement"},{"name":"JSPS Grant-in-Aid for Scientific Research (A)","award":["22H00439"],"award-info":[{"award-number":["22H00439"]}]},{"name":"JSPS Grant-in-Aid for Specially Promoted Research","award":["JP20H05618"],"award-info":[{"award-number":["JP20H05618"]}]},{"name":"Science for Life Laboratory, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2026,6,19]]},"DOI":"10.1021\/acschembio.6c00275","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:54:09Z","timestamp":1780980849000},"page":"1507-1515","source":"Crossref","is-referenced-by-count":0,"title":["A RaPID Macrocyclic Peptide Inhibitor of ROR1\/2 Strongly Reduces Proliferation of Diffuse Intrinsic Pontine Glioma Cells"],"prefix":"10.1021","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1964-9243","authenticated-orcid":true,"given":"Kilian","family":"Colas","sequence":"first","affiliation":[{"name":"Department of Chemistry, Graduate School of Science, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl O.","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Science for Life Laboratory","place":["Uppsala, Sweden"]},{"name":"Uppsala University","place":["Uppsala, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srijita","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Science for Life Laboratory","place":["Uppsala, Sweden"]},{"name":"Uppsala University","place":["Uppsala, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Giraud","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Science for Life Laboratory","place":["Uppsala, Sweden"]},{"name":"Uppsala University","place":["Uppsala, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik J.","family":"Swartling","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Science for Life Laboratory","place":["Uppsala, Sweden"]},{"name":"Uppsala University","place":["Uppsala, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6550-6203","authenticated-orcid":true,"given":"Takayuki","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Graduate School of Science, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-9186","authenticated-orcid":true,"given":"Hiroaki","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Graduate School of Science, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac161"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab200"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-023-01316-9"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13142398"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00237"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216876"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox107"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.680834"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-014-0059-7"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014760"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.01.010"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83535"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2025-2359"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02239-1"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/srep36447"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031127"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08952-9"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.09.085"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712148105"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1599355"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11797"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080812"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15041148"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1816262116"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202500247"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-24-2172"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.omton.2024.200927"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00190.x"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14983"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-025-01744-9"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00422"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ph18050617"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00135-8"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-023-00563-1"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-020-0525-1"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/bulcsj\/uoae018"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c01979"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.331"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","unstructured":"Katoh, T.; Goto, Y.; Suga, H.\n                      In Vitro Selection of Thioether-Closed Macrocyclic Peptide Ligands by Means of the RaPID System\n                      .\n                      Peptide Macrocycles: Methods and Protocols\n                      , Coppock, M. B.; Winton, A. J.; Springer, 2022; pp 247\u2013259.","DOI":"10.1007\/978-1-0716-1689-5_13"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00391"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.786269"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15630"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noae224"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3172"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.03.007"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.322"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-12-3832"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222879"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2218238120"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.21769\/bioprotoc.3253"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2024.106930"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00175"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.6c00275","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.6c00275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:13:10Z","timestamp":1781856790000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.6c00275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,19]]}},"alternative-id":["10.1021\/acschembio.6c00275"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.6c00275","relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv.15000878\/v1","asserted-by":"object"}]},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]}}}