{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:52:52Z","timestamp":1781859172921,"version":"3.54.5"},"reference-count":85,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R35NS116846"],"award-info":[{"award-number":["R35NS116846"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["963835"],"award-info":[{"award-number":["963835"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2026,6,19]]},"DOI":"10.1021\/acschembio.6c00337","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:48:53Z","timestamp":1778219333000},"page":"1562-1575","source":"Crossref","is-referenced-by-count":0,"title":["An RNA-Focused DNA-Encoded Library Platform for Discovering Ligands of Pathogenic r(G\n                    <sub>4<\/sub>\n                    C\n                    <sub>2<\/sub>\n                    )\n                    <sup>exp<\/sup>\n                    RNA"],"prefix":"10.1021","volume":"21","author":[{"given":"Xueyi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States"},{"name":"Department of Chemistry","place":["Jupiter, United States"]},{"name":"The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology Way","place":["Jupiter, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Taghavi","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Jupiter, United States"]},{"name":"The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology Way","place":["Jupiter, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Akahori","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Jupiter, United States"]},{"name":"The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology Way","place":["Jupiter, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Pedrini","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Jupiter, United States"]},{"name":"The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology Way","place":["Jupiter, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1664-6191","authenticated-orcid":true,"given":"Takahiro","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Jupiter, United States"]},{"name":"The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology Way","place":["Jupiter, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8486-1796","authenticated-orcid":true,"given":"Matthew D.","family":"Disney","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States"},{"name":"Department of Chemistry","place":["Jupiter, United States"]},{"name":"The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology Way","place":["Jupiter, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/science.166.3903.393"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2016.05.021"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a034769"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.93"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b13419"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5381"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.211"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00521-4"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00713-6"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805130105"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ja073993a"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201701644"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b04880"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00084-5"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c08852"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c07217"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.2c00797"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-023-01458-4"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b08085"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c09213"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00714"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC00961C"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.0c00357"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2114971119"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08883"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac173"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.202300073"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.slasd.2024.100204"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.5b00106"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/354082a0"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00855"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0047-2"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4065"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1315438110"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1149-y"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu120"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/nature20413"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1126\/science.adv2600"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2210532119"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd5991"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.07.041"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00001"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201707641"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.8b00049"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2018.08.003"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1177\/2472555219885373"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2119"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.5b00198"},{"key":"ref51\/cit51","unstructured":"RDKit: Open-Source\nCheminformatics\n                      . https:\/\/www.rdkit.org."},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/ci100050t"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1101\/2025.06.16.659994"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-025-01190-4"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/cr9600114"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/nature13067"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn517"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C113.502336"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.10.018"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201707850"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1177\/108705719600100111"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/co500030f"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.2307\/2346830"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-018-0258-y"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.0c01006"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/ct200162x"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00768"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/ja507448y"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c01929"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.029"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1021\/ja9020149"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201804368"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1021\/cb400265y"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2020.05.011"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01742"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b08039"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006280"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2005447117"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202511839"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1038\/s44386-025-00007-4"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00452"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00789"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202000445"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1021\/ja906877y"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06091-8"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.6c00337","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.6c00337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:13:20Z","timestamp":1781856800000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.6c00337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":85,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,19]]}},"alternative-id":["10.1021\/acschembio.6c00337"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.6c00337","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]}}}