{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:51:11Z","timestamp":1792079471004,"version":"4.4.0"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A subset of endogenous steroids can be formed in the brain and exhibit brain-specific activities linked to neuronal health and disease. Despite the biological relevance of these so-called neurosteroids, molecular profiling of their effects is incomplete and their signature in the nuclear hormone receptor family that mediates signals of classical steroid hormones is elusive. Here, we present a comprehensive characterization of neurosteroids for nuclear receptor modulation and reveal pronounced inverse ROR\u03b3 agonism as a relevant molecular mechanism of several abundant neurosteroids, with an impact on circadian rhythms and transcriptomic profiles in cellular settings. Structural analysis of the DHEA-ROR\u03b3 interaction demonstrated orthosteric binding and pronounced rearrangements in the ROR\u03b3 ligand binding domain to a fully repressed state, rationalizing the strong inverse agonist efficacy.<\/jats:p>","DOI":"10.1021\/acschembio.6c00373","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T10:01:57Z","timestamp":1786615317000},"page":"2216-2223","source":"Crossref","is-referenced-by-count":0,"title":["Neurosteroids Inhibit ROR\u03b3 and Induce Major Rearrangement of Its Activation Motif"],"prefix":"10.1021","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-9584","authenticated-orcid":true,"given":"\u00darsula","family":"L\u00f3pez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , , ,","place":["Munich, Germany, 81377"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6053-9566","authenticated-orcid":true,"given":"Minh","family":"Sai","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , , ,","place":["Munich, Germany, 81377"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Ge","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , , ,","place":["Munich, Germany, 81377"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3777-4697","authenticated-orcid":true,"given":"Emily C.","family":"Hank","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , , ,","place":["Munich, Germany, 81377"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wein","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , , ,","place":["Munich, Germany, 81377"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian A.","family":"Marschner","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , , ,","place":["Munich, Germany, 81377"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasily","family":"Morozov","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , , ,","place":["Munich, Germany, 81377"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5359-8128","authenticated-orcid":true,"given":"Daniel","family":"Merk","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , , ,","place":["Munich, Germany, 81377"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2026101511062016100_cit1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-59259-829-8_4","article-title":"Steroid Hormones","volume-title":"Endocrinology: Basic and clinical principles","author":"Henley","year":"2005","edition":"2"},{"key":"2026101511062016100_cit2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2018.06.007","article-title":"Neuroactive Steroids, Neurosteroidogenesis and Sex","volume":"176","author":"Giatti","year":"2019","journal-title":"Prog. Neurobiol."},{"issue":"8","key":"2026101511062016100_cit3","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/s0306-4530(98)00071-7","article-title":"Neurosteroids: A Novel Function of the Brain","volume":"23","author":"Baulieu","year":"1998","journal-title":"Psychoneuroendocrinology"},{"key":"2026101511062016100_cit4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.neubiorev.2015.09.023","article-title":"Levels and Actions of Neuroactive Steroids in the Nervous System under Physiological and Pathological Conditions: Sex-Specific Features","volume":"67","author":"Melcangi","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"C","key":"2026101511062016100_cit5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/B978-0-444-53630-3.00008-7","article-title":"Neurosteroids: Endogenous Role in the Human Brain and Therapeutic Potentials","volume":"186","author":"Reddy","year":"2010","journal-title":"Prog. Brain Res."},{"key":"2026101511062016100_cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2024.106485","article-title":"Neurosteroids: A Potential Target for Neuropsychiatric Disorders","volume":"239","author":"Wang","year":"2024","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1","key":"2026101511062016100_cit7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41386-023-01626-z","article-title":"Neurosteroids: Mechanistic Considerations and Clinical Prospects","volume":"49","author":"Maguire","year":"2024","journal-title":"Neuropsychopharmacology"},{"issue":"9","key":"2026101511062016100_cit8","doi-asserted-by":"publisher","first-page":"706","DOI":"10.2174\/1871527317666180817153914","article-title":"Dehydroepiandrosterone (DHEA) for Depression: A Systematic Review and Meta-Analysis","volume":"17","author":"Peixoto","year":"2018","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"issue":"1","key":"2026101511062016100_cit9","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1016\/j.archger.2009.07.001","article-title":"Decreased Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulfate (DHEAS) Concentrations in Plasma of Alzheimer\u2019s Disease (AD) Patients","volume":"51","author":"Aldred","year":"2010","journal-title":"Arch. Gerontol. Geriatr."},{"key":"2026101511062016100_cit10","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000304","article-title":"Dehydroepiandrosterone (DHEA) Supplementation for Cognitive Function","author":"Huppert","year":"2001","journal-title":"Cochrane Database Syst. Rev."},{"issue":"8","key":"2026101511062016100_cit11","doi-asserted-by":"publisher","first-page":"941","DOI":"10.2174\/1389557522666220919125817","article-title":"Dehydroepiandrosterone (DHEA): Pharmacological Effects and Potential Therapeutic Application","volume":"23","author":"Nenezic","year":"2023","journal-title":"Mini Rev. Med. Chem."},{"key":"2026101511062016100_cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2019.100788","article-title":"Neurosteroids as Regulators of Neuroinflammation","volume":"55","author":"Yilmaz","year":"2019","journal-title":"Front. Neuroendocrinol."},{"key":"2026101511062016100_cit13","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3389\/fendo.2019.00169","article-title":"Neurosteroid Actions in Memory and Neurologic\/Neuropsychiatric Disorders","volume":"10","author":"Ratner","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"7","key":"2026101511062016100_cit14","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.tips.2016.04.003","article-title":"Clinical Potential of Neurosteroids for CNS Disorders","volume":"37","author":"Reddy","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"issue":"3","key":"2026101511062016100_cit15","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00210-005-1022-1","article-title":"The Effects of the Neurosteroids: Pregnenolone, Progesterone and Dehydroepiandrosterone on Muscarinic Receptor-Induced Responses in Xenopus Oocytes Expressing M1 and M3 Receptors","volume":"371","author":"Horishita","year":"2005","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"2026101511062016100_cit16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/bs.vh.2018.02.003","article-title":"Mechanisms of Action of Dehydroepiandrosterone","volume":"108","author":"Clark","year":"2018","journal-title":"Vitam. Horm."},{"issue":"1","key":"2026101511062016100_cit17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s0092-8674(00)80900-9","article-title":"An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway","volume":"92","author":"Kliewer","year":"1998","journal-title":"Cell"},{"key":"2026101511062016100_cit18","doi-asserted-by":"publisher","first-page":"280704","DOI":"10.3389\/fneur.2017.00442","article-title":"Neuroactive Steroids: Receptor Interactions and Responses","volume":"8","author":"Tuem","year":"2017","journal-title":"Front. Neurol."},{"issue":"36","key":"2026101511062016100_cit19","doi-asserted-by":"publisher","first-page":"11896","DOI":"10.1523\/JNEUROSCI.1898-10.2010","article-title":"Activation of the Liver X Receptor Increases Neuroactive Steroid Levels and Protects from Diabetes-Induced Peripheral Neuropathy","volume":"30","author":"Cermenati","year":"2010","journal-title":"J. Neurosci."},{"issue":"14","key":"2026101511062016100_cit20","doi-asserted-by":"publisher","first-page":"9592","DOI":"10.1021\/acs.jmedchem.1c00186","article-title":"Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation","volume":"64","author":"Willems","year":"2021","journal-title":"J. Med. Chem."},{"issue":"14","key":"2026101511062016100_cit21","doi-asserted-by":"publisher","first-page":"9548","DOI":"10.1021\/acs.jmedchem.2c00585","article-title":"Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration","volume":"65","author":"Willems","year":"2022","journal-title":"J. Med. Chem."},{"issue":"4","key":"2026101511062016100_cit22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/s41580-018-0096-9","article-title":"Crosstalk between Metabolism and Circadian Clocks","volume":"20","author":"Reinke","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"2026101511062016100_cit23","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/nri3386","article-title":"Circadian Control of the Immune System","volume":"13","author":"Scheiermann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"2026101511062016100_cit24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrd4100","article-title":"REV-ERB and ROR Nuclear Receptors as Drug Targets","volume":"13","author":"Kojetin","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"issue":"15","key":"2026101511062016100_cit25","doi-asserted-by":"publisher","first-page":"10519","DOI":"10.1021\/acs.jmedchem.0c02178","article-title":"Agonist Lock Touched and Untouched Retinoic Acid Receptor-Related Orphan Receptor-\u0393t (ROR\u03b3t) Inverse Agonists: Classification Based on the Molecular Mechanisms of Action","volume":"64","author":"Sun","year":"2021","journal-title":"J. Med. Chem."},{"issue":"24","key":"2026101511062016100_cit26","doi-asserted-by":"publisher","first-page":"10976","DOI":"10.1021\/acs.jmedchem.8b00588","article-title":"Combating Autoimmune Diseases with Retinoic Acid Receptor-Related Orphan Receptor-\u03b3 (ROR\u03b3 or RORc) Inhibitors: Hits and Misses","volume":"61","author":"Pandya","year":"2018","journal-title":"J. Med. Chem."},{"issue":"13","key":"2026101511062016100_cit27","doi-asserted-by":"publisher","first-page":"9238","DOI":"10.1021\/acs.jmedchem.1c00475","article-title":"Structure-Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor \u0393t","volume":"64","author":"Meijer","year":"2021","journal-title":"J. Med. Chem."},{"issue":"5","key":"2026101511062016100_cit28","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1210\/me.2009-0507","article-title":"Structural Basis for Hydroxycholesterols as Natural Ligands of Orphan Nuclear Receptor RORgamma","volume":"24","author":"Jin","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"2026101511062016100_cit29","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nchembio.1714","article-title":"Sterol Metabolism Controls T(H)17 Differentiation by Generating Endogenous ROR\u03b3 Agonists","volume":"11","author":"Hu","year":"2015","journal-title":"Nat. Chem. Biol."},{"issue":"8","key":"2026101511062016100_cit30","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.bbalip.2010.02.012","article-title":"A Second Class of Nuclear Receptors for Oxysterols: Regulation of ROR\u03b1 and ROR\u03b3 Activity by 24S-Hydroxycholesterol (Cerebrosterol)","volume":"1801","author":"Wang","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"2026101511062016100_cit31","doi-asserted-by":"publisher","first-page":"4621","DOI":"10.1038\/s41467-019-12529-3","article-title":"ROR\u03b3 Is a Targetable Master Regulator of Cholesterol Biosynthesis in a Cancer Subtype","volume":"10","author":"Cai","year":"2019","journal-title":"Nat. Commun."},{"issue":"4","key":"2026101511062016100_cit32","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41388-023-02903-3","article-title":"The ROR\u0263\/SREBP2 Pathway Is a Master Regulator of Cholesterol Metabolism and Serves as Potential Therapeutic Target in t(4;11) Leukemia","volume":"43","author":"Erkner","year":"2023","journal-title":"Oncogene"},{"issue":"9","key":"2026101511062016100_cit33","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/s0166-2236(99)01399-5","article-title":"Neuroactive Steroids: Mechanisms of Action and Neuropsychopharmacological Perspectives","volume":"22","author":"Rupprecht","year":"1999","journal-title":"Trends Neurosci."},{"issue":"6","key":"2026101511062016100_cit34","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/0197-0186(85)90143-3","article-title":"Neuro-Steroids: 3\u03b2-Hydroxy-\u03945-Derivatives in the Rodent Brain","volume":"7","author":"Robel","year":"1985","journal-title":"Neurochem. Int."},{"issue":"1\u20133","key":"2026101511062016100_cit35","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0960-0760(91)90169-6","article-title":"Neurosteroids: Biosynthesis, Metabolism and Function of Pregnenolone and Dehydroepiandrosterone in the Brain","volume":"40","author":"Akwa","year":"1991","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"10","key":"2026101511062016100_cit36","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1021\/acschemneuro.3c00131","article-title":"Effects of Pregnanolone Glutamate and Its Metabolites on GABAA and NMDA Receptors and Zebrafish Behavior","volume":"14","author":"Abramova","year":"2023","journal-title":"ACS Chem. Neurosci."},{"issue":"10","key":"2026101511062016100_cit37","doi-asserted-by":"publisher","first-page":"4553","DOI":"10.1073\/pnas.88.10.4553","article-title":"Stress-Induced Elevations of \u03b3-Aminobutyric Acid Type a Receptor-Active Steroids in the Rat Brain","volume":"88","author":"Purdy","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"2026101511062016100_cit38","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1016\/s0022-2275(20)32188-x","article-title":"Cholesterol Homeostasis in Human Brain: Turnover of 24S- Hydroxycholesterol and Evidence for a Cerebral Origin of Most of This Oxysterol in the Circulation","volume":"39","author":"Bj\u00f6rkhem","year":"1998","journal-title":"J. Lipid Res."},{"key":"2026101511062016100_cit39","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1196\/annals.1286.007","article-title":"Neurosteroid Biosynthesis in the Human Brain and Its Clinical Implications","volume":"1007","author":"Stoffel-Wagner","year":"2003","journal-title":"New York Acad. Sci."},{"issue":"4","key":"2026101511062016100_cit40","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1021\/cb200496y","article-title":"Identification of SR2211: A Potent Synthetic ROR\u03b3-Selective Modulator","volume":"7","author":"Kumar","year":"2012","journal-title":"ACS Chem. Biol."},{"issue":"6","key":"2026101511062016100_cit41","doi-asserted-by":"publisher","first-page":"2564","DOI":"10.4049\/jimmunol.1302190","article-title":"Pharmacologic Inhibition of ROR\u03b3t Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation in Vivo","volume":"192","author":"Skepner","year":"2014","journal-title":"J. Immunol."},{"issue":"2","key":"2026101511062016100_cit42","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1124\/mol.109.060905","article-title":"The Benzenesulfoamide T0901317 [N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2- Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenyl]-Benzenesulfonamide] Is a Novel Retinoic Acid Receptor-Related Orphan Receptor-\u03b1\/\u03b3 Inverse Agonist","volume":"77","author":"Kumar","year":"2010","journal-title":"Mol. Pharmacol."},{"issue":"41","key":"2026101511062016100_cit43","doi-asserted-by":"publisher","first-page":"12757","DOI":"10.1523\/JNEUROSCI.3340-09.2009","article-title":"Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function","volume":"29","author":"Belelli","year":"2009","journal-title":"J. Neurosci."},{"issue":"Pt 3","key":"2026101511062016100_cit44","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1113\/jphysiol.2007.142794","article-title":"Neurosteroid Migration to Intracellular Compartments Reduces Steroid Concentration in the Membrane and Diminishes GABA-A Receptor Potentiation","volume":"584","author":"Li","year":"2007","journal-title":"J. Physiol."},{"issue":"10","key":"2026101511062016100_cit45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224081","article-title":"Rapid and Structure-Specific Cellular Uptake of Selected Steroids","volume":"14","author":"McManus","year":"2019","journal-title":"PLoS One"},{"issue":"6","key":"2026101511062016100_cit46","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/gtc.12494","article-title":"Ternary Complex of Human ROR\u03b3 Ligand-Binding Domain, Inverse Agonist and SMRT Peptide Shows a Unique Mechanism of Corepressor Recruitment","volume":"22","author":"Noguchi","year":"2017","journal-title":"Genes Cells"},{"issue":"13","key":"2026101511062016100_cit47","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1002\/cmdc.201700278","article-title":"Structural States of ROR\u03b3t: X-Ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds","volume":"12","author":"Kallen","year":"2017","journal-title":"ChemMedChem"},{"issue":"10","key":"2026101511062016100_cit48","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.3390\/cells9102323","article-title":"Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis","volume":"9","author":"Witzig","year":"2020","journal-title":"Cells"},{"issue":"1","key":"2026101511062016100_cit49","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/s41420-024-01960-1","article-title":"Circadian Rhythm Regulates the Function of Immune Cells and Participates in the Development of Tumors","volume":"10","author":"Zeng","year":"2024","journal-title":"Cell Death Discov."},{"issue":"4\u20136","key":"2026101511062016100_cit50","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/0022-4731(87)90133-6","article-title":"Neuro-Steroids: 3\u03b2-Hydroxy-\u03945-Derivatives in Rat and Monkey Brain","volume":"27","author":"Robel","year":"1987","journal-title":"J. Steroid Biochem."},{"issue":"23","key":"2026101511062016100_cit51","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1016\/s0024-3205(99)00516-0","article-title":"Neuroactive Steroids Alter the Circadian System of the Syrian Hamster in a Phase-Dependent Manner","volume":"65","author":"De Tezanos Pinto","year":"1999","journal-title":"Life Sci."},{"issue":"5","key":"2026101511062016100_cit52","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708724","article-title":"Identification of Circadian Clock Modulators from Existing Drugs","volume":"10","author":"Tamai","year":"2018","journal-title":"EMBO Mol. Med."},{"issue":"3","key":"2026101511062016100_cit53","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.cmet.2016.07.024","article-title":"The Pentose Phosphate Pathway Regulates the Circadian Clock","volume":"24","author":"Rey","year":"2016","journal-title":"Cell Metab."},{"issue":"5","key":"2026101511062016100_cit54","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1177\/0748730410379711","article-title":"JTK_CYCLE: An Efficient Non-Parametric Algorithm for Detecting Rhythmic Components in Genome-Scale Datasets","volume":"25","author":"Hughes","year":"2010","journal-title":"J. Biol. Rhythms"},{"issue":"1","key":"2026101511062016100_cit55","doi-asserted-by":"publisher","first-page":"4698","DOI":"10.1038\/s41467-019-12680-x","article-title":"NFAT Primes the Human RORC Locus for ROR\u03b3t Expression in CD4+ T Cells","volume":"10","author":"Yahia-Cherbal","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"2026101511062016100_cit56","doi-asserted-by":"publisher","first-page":"4515","DOI":"10.1038\/s41467-018-06924-5","article-title":"SUMOylation of ROR-\u0393t Inhibits IL-17 Expression and Inflammation via HDAC2","volume":"9","author":"Singh","year":"2018","journal-title":"Nat. Commun."},{"key":"2026101511062016100_cit57","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s42004-025-01427-z","article-title":"Chemogenomics for Steroid Hormone Receptors (NR3)","volume":"8","author":"Schallmayer","year":"2025","journal-title":"Commun. Chem."},{"issue":"4","key":"2026101511062016100_cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114725","article-title":"ROR\u03b3 Is a Context-Specific Master Regulator of Cholesterol Biosynthesis and an Emerging Therapeutic Target in Cancer and Autoimmune Diseases","volume":"196","author":"Zou","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"6315","key":"2026101511062016100_cit59","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1126\/science.aah4968","article-title":"Mechanisms Linking Circadian Clocks, Sleep, and Neurodegeneration","volume":"354","author":"Panda","year":"2016","journal-title":"Science"},{"issue":"12","key":"2026101511062016100_cit60","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1101\/gad.302323.117","article-title":"The Hepatic Circadian Clock Fine-Tunes the Lipogenic Response to Feeding through ROR\u03b1\/\u03b3","volume":"31","author":"Zhang","year":"2017","journal-title":"Genes Dev."},{"issue":"1","key":"2026101511062016100_cit61","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1080\/19768354.2024.2347503","article-title":"Circadian Coordination: Understanding Interplay between Circadian Clock and Mitochondria","volume":"28","author":"Kim","year":"2024","journal-title":"Animal Cells Syst. (Seoul)."},{"issue":"11","key":"2026101511062016100_cit62","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28114432","article-title":"Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria","volume":"28","author":"Xu","year":"2023","journal-title":"Molecules"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.6c00373","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acbcct\/article-pdf\/21\/9\/2216\/66522175\/cb-2026-00373w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acbcct\/article-pdf\/21\/9\/2216\/66522175\/cb-2026-00373w.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:30:43Z","timestamp":1792078243000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acbcct\/article\/21\/9\/2216\/5254108\/Neurosteroids-Inhibit-ROR-and-Induce-Major"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":62,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,8,13]]},"published-print":{"date-parts":[[2026,9,18]]}},"URL":"https:\/\/doi.org\/10.1021\/acschembio.6c00373","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}