{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:47:02Z","timestamp":1792057622890,"version":"4.4.0"},"reference-count":70,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2024\/54\/E\/NZ5\/00234"],"award-info":[{"award-number":["2024\/54\/E\/NZ5\/00234"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>G-quadruplex (G4) DNA structures are key regulatory elements in genome stability and gene expression, with a pronounced role in cancer biology due to their selective formation in oncogenic genomic regions and abundance in tumor cells. Their structural uniqueness makes them compelling targets for therapeutic intervention. Thus, targeting G4s with small molecule ligands offers a promising approach for modulating gene expression and inducing replication stress, particularly in DNA damage response-deficient malignancies such as ovarian and breast cancers. However, the structural diversity of G4s has hindered the development of ligands capable of broad-spectrum, topology-independent stabilization. Here, we introduce a novel dimeric N-methylbenzo[c]acridinium derivative, engineered as a visible-light-absorbing cationic G4 ligand. Compared to previously reported diazonia derivatives, this compound demonstrates red-shifted optical properties, superior luminescence quantum efficiency, and outstanding G4-stabilizing activity. It exhibits high preferential binding for G4s over dsDNA, induces conformational transitions between hybrid and antiparallel G4s, stalls DNA replication, and disrupts DNA duplex formation. Notably, its broad, topology-independent recognition enables stabilization of a range of G4 targets. Crucially, it surpasses benchmark G4 ligands, including PhenDC3 and CX-5461, in both selectivity and\/or efficacy. These results support the dimeric benzo[c]acridinium scaffold as a versatile platform for the development of G4-targeted therapeutic strategies.<\/jats:p>","DOI":"10.1021\/acschembio.6c00586","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:01:15Z","timestamp":1792054875000},"source":"Crossref","is-referenced-by-count":0,"title":["Benzo[\n                    <i>c<\/i>\n                    ]acridine Dimer Cyclization as a Route toward a Small Bicationic Heteroaromatic Compound with Unprecedented G-Quadruplex Stabilization Properties"],"prefix":"10.1021","author":[{"given":"Stefanie Sandra","family":"Sandberg","sequence":"first","affiliation":[{"name":"Ume\u00e5 University , , ,","place":["Ume\u00e5, Sweden, 901 87"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Pitrat","sequence":"additional","affiliation":[{"name":"CNRS, ENS de Lyon, LCH UMR 5182 , ,","place":["Lyon, France, 69007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Labro","sequence":"additional","affiliation":[{"name":"ENS de Lyon, CNRS, LCH UMR 5182 , ,","place":["Lyon, France, 69007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh Farmand","family":"Azadeh","sequence":"additional","affiliation":[{"name":"Ume\u00e5 University , , ,","place":["Ume\u00e5, Sweden, 901 87"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7815-4494","authenticated-orcid":true,"given":"Marco","family":"Deiana","sequence":"additional","affiliation":[{"name":"Wroc\u0142aw University of Science and Technology , , Wyb. Wyspia\u0144skiego 27 , ,","place":["Wroc\u0142aw, Poland, 50-370"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-081X","authenticated-orcid":true,"given":"Tangui","family":"Le Bahers","sequence":"additional","affiliation":[{"name":"ENS de Lyon, CNRS, LCH UMR 5182 , ,","place":["Lyon, France, 69007"]},{"name":"Institut Universitaire de France , 5 rue Descartes , ,","place":["Paris, France, 75005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Denis-Quanquin","sequence":"additional","affiliation":[{"name":"CNRS, ENS de Lyon, LCH UMR 5182 , ,","place":["Lyon, France, 69007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-2416","authenticated-orcid":true,"given":"Cyrille","family":"Monnereau","sequence":"additional","affiliation":[{"name":"ENS de Lyon, CNRS, LCH UMR 5182 , ,","place":["Lyon, France, 69007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7657-6861","authenticated-orcid":true,"given":"Natacha","family":"Gillet","sequence":"additional","affiliation":[{"name":"CNRS, ENS de Lyon, LCH UMR 5182 , ,","place":["Lyon, France, 69007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4541-7702","authenticated-orcid":true,"given":"Nasim","family":"Sabouri","sequence":"additional","affiliation":[{"name":"Ume\u00e5 University , , ,","place":["Ume\u00e5, Sweden, 901 87"]},{"name":"Ume\u00e5 University , , ,","place":["Ume\u00e5, Sweden, 901 87"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-7213","authenticated-orcid":true,"given":"Laure","family":"Guy","sequence":"additional","affiliation":[{"name":"ENS de Lyon, CNRS, LCH UMR 5182 , ,","place":["Lyon, France, 69007"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"2026101505011218200_cit1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202500429","article-title":"\u03c0-Expanded Nitrogen-Cation (N+)-Doped Polycyclic Aromatic Hydrocarbons: A Review of Intramolecular Cyclization Routes to Benzo[c]Quinolizinium, Triazinium, Pyridoquinazolinium, and Pyridoquinoxalinium Frameworks","volume":"29","author":"Labro","year":"2026","journal-title":"Eur. 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