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Genetic elements that can spread by drive include gametic and zygotic killers, meiotic drivers, homing endonuclease genes, B chromosomes, and transposable elements. The fact that gene drive can lead to the spread of fitness-reducing traits (including lethality and sterility) makes it an attractive process to consider exploiting to control disease vectors and other pests. There are a number of efforts to develop synthetic gene drive systems, particularly focused on the mosquito-borne diseases that continue to plague us.<\/jats:p>","DOI":"10.1021\/acschembio.7b01031","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T13:56:02Z","timestamp":1517838962000},"page":"343-346","source":"Crossref","is-referenced-by-count":98,"title":["Gene Drive: Evolved and Synthetic"],"prefix":"10.1021","volume":"13","author":[{"given":"Austin","family":"Burt","sequence":"first","affiliation":[{"name":"Life Sciences, Imperial College , Silwood Park , , ,","place":["Ascot, United Kingdom, SL5 7PY"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Crisanti","sequence":"additional","affiliation":[{"name":"Life Sciences, Imperial College , South Kensington , , ,","place":["London, United Kingdom, SW7 2AZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"2026090316320077600_cit1","doi-asserted-by":"crossref","DOI":"10.4159\/9780674029118","volume-title":"Genes\nin Conflict: the Biology of Selfish Genetic Elements","author":"Burt","year":"2006"},{"key":"2026090316320077600_cit2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0169-5347(88)90105-X","article-title":"Selfish\ngenetic elements","volume":"3","author":"Werren","year":"1988","journal-title":"Trends\nEcol. 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