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Here, we report the design and use of conditional epitopes for time-controlled T-cell activation in vivo. We show that trans-cyclooctene-protected SIINFEKL (with the lysine amine masked) is unable to elicit the T-cell response characteristic for the free SIINFEKL epitope. Epitope uncaging by means of an inverse-electron demand Diels\u2013Alder (IEDDA) event restored T-cell activation and provided temporal control of T-cell proliferation in vivo.<\/jats:p>","DOI":"10.1021\/acschembio.8b00155","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T11:07:07Z","timestamp":1525691227000},"page":"1569-1576","source":"Crossref","is-referenced-by-count":46,"title":["Chemical Control over T-Cell Activation\n                    <i>in Vivo<\/i>\n                    Using Deprotection of\n                    <i>trans<\/i>\n                    -Cyclooctene-Modified\nEpitopes"],"prefix":"10.1021","volume":"13","author":[{"given":"Anouk M. 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