{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:08:22Z","timestamp":1781248102119,"version":"3.54.1"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI126755"],"award-info":[{"award-number":["R21AI126755"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2019,7,19]]},"DOI":"10.1021\/acschembio.9b00293","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T16:27:44Z","timestamp":1560270464000},"page":"1528-1535","source":"Crossref","is-referenced-by-count":13,"title":["Small-Molecule Inhibition of the <i>C. difficile<\/i> FAS-II Enzyme, FabK, Results in Selective Activity"],"prefix":"10.1021","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8006-5661","authenticated-orcid":true,"given":"Jesse A.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5650-4644","authenticated-orcid":true,"given":"Allan M.","family":"Prior","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii, 96720, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-406X","authenticated-orcid":true,"given":"Ravi K. R.","family":"Marreddy","sequence":"additional","affiliation":[{"name":"Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas 77030, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca D.","family":"Wahrmund","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2214-8105","authenticated-orcid":true,"given":"Julian G.","family":"Hurdle","sequence":"additional","affiliation":[{"name":"Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas 77030, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7330-1742","authenticated-orcid":true,"given":"Dianqing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii, 96720, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-3625","authenticated-orcid":true,"given":"Kirk E.","family":"Hevener","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2017-0203"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis335"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis319"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00845-13"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp110371"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.2174\/1568026613666131113154753"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02291-12"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2008.08.012"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00885-17"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01543"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910812"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis495"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.11.142"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1085"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00096"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12102"},{"key":"ref17\/cit17","first-page":"146","volume":"5","author":"Heath R. J.","year":"2004","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00400-09"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02307-12"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1179\/1973947815Y.0000000075"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005611200"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021699"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708171200"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-9-r102"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.8b00205"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/35018162"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X18000262"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1110\/ps.073288808"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.08.050"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/jm0705354"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.06.040"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00270-06"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309106017039"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.74.082803.133524"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(02)00164-3"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nature07772"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/nature08667"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/nature08668"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2011.07.029"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2013.02.002"},{"key":"ref41\/cit41","first-page":"297","volume-title":"Handbook on Clostridia","author":"Goldfine H.","year":"2004"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.06.011"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nature09944"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078922"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00647-16"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22581"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01957-12"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00648-18"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1055\/s-1990-27109"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2012.05.002"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2012.03.013"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.9b00293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T15:52:41Z","timestamp":1682610761000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.9b00293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7,19]]}},"alternative-id":["10.1021\/acschembio.9b00293"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.9b00293","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,11]]}}}