{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:30:48Z","timestamp":1788618648327,"version":"build-2803163510"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"UAMS College of Medicine"},{"name":"Arkansas Breast Cancer Program"},{"name":"Little Rock Envoys Seeds of Science Award"},{"name":"Barton Endowment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2019,6,21]]},"DOI":"10.1021\/acschembio.9b00304","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T18:11:20Z","timestamp":1557771080000},"page":"1337-1351","source":"Crossref","is-referenced-by-count":21,"title":["Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms"],"prefix":"10.1021","volume":"14","author":[{"given":"Amit","family":"Ketkar","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Maddukuri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narsimha R.","family":"Penthala","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan R.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroof K.","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Crooks","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4776-8925","authenticated-orcid":true,"given":"Robert L.","family":"Eoff","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.7b00157"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2017.1291576"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1101\/gad.14.13.1589","volume":"14","author":"Ohashi E.","year":"2000","journal-title":"Genes Dev."},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222377899"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2016.11.001"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602246200"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501562200"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.9.3527-3540.2006"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1186\/s41021-016-0067-3"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/em.21961"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2009.09.003"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20509"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/em.21721"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.11.016"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr889"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41426"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.148"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.4161\/cc.26976"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nop074"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1884"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5b00452"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/nature10491"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.11.007"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.2001.00478.x"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2012.09.004"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.457"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1158\/0008-5472.325.65.1","volume":"65","author":"Bavoux C.","year":"2005","journal-title":"Cancer Res."},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201702006"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/cb400305r"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp641"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/cb100382m"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/cb4007562"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.01.064"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3390\/md7040624"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045032"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.07.026"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.01.022"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/jm5010495"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1455"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b01144"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/tx300392m"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b01176"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.01.051"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092444"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2012.03.004"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-2464"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3916"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.18632\/oncotarget.124","volume":"1","author":"Higgins G. S.","year":"2010","journal-title":"Oncotarget"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1095"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/nature03482"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011412107"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1421365112"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2015.1043482"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1328"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2007.12.012"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-05-0118"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2004.05.011"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.003905"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.551820"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/nature09196"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202681109"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.01.018"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw204"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.9b00304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T08:25:34Z","timestamp":1682497534000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.9b00304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,13]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6,21]]}},"alternative-id":["10.1021\/acschembio.9b00304"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.9b00304","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,13]]}}}