{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:49:26Z","timestamp":1789058966828,"version":"build-2803163510"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI085051"],"award-info":[{"award-number":["R01 AI085051"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2020,2,21]]},"DOI":"10.1021\/acschembio.9b00675","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T11:58:34Z","timestamp":1577102314000},"page":"342-352","source":"Crossref","is-referenced-by-count":22,"title":["Molecular and Structural Mechanism of Pan-Genotypic HCV NS3\/4A Protease Inhibition by Glecaprevir"],"prefix":"10.1021","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9750-3293","authenticated-orcid":true,"given":"Jennifer","family":"Timm","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klajdi","family":"Kosovrasti","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Henes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Leidner","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3491-791X","authenticated-orcid":true,"given":"Akbar","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5036-676X","authenticated-orcid":true,"given":"Nese","family":"Kurt Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2270-6613","authenticated-orcid":true,"given":"Celia A.","family":"Schiffer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"ref1\/cit1","unstructured":"World Health Organization (WHO). Hepatitis C, Fact Sheet (Updated July 2018). http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-c. (accessed Nov 30, 2018)."},{"key":"ref2\/cit2","unstructured":"World Health Organization (WHO).\n                      Global Hepatitis Report, 2017\n                      : http:\/\/www.who.int\/hepatitis\/publications\/global-hepatitis-report2017\/en\/. (accessed Nov 30, 2018)."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27259"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.027"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26744"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2575"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.10.024"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"ref9\/cit9","unstructured":"Hepatitis C Guidance: AASLD-IDSA. Recommendations for testing, managing,\nand treating hepatitis C. http:\/\/www.hcvguidelines.org. (accessed Nov 30, 2018)."},{"key":"ref10\/cit10","unstructured":"World Health Organization (WHO).\n                      Guidelines for the care and treatment of\npersons diagnosed with chronic hepatitis C virus infection\n                      (July 2018): http:\/\/www.who.int\/hepatitis\/publications\/hepatitis-c-guidelines-2018\/en\/. (accessed Nov 30, 2018)."},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b06454"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512610"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613512"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.01.050"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702417"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.09.027"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01249-18"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.003"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2018.01.004"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-018-1188-3"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.07.015"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/cb400100g"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002832"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00324-12"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805267115"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01620-17"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3202"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.10.031"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002832"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.163"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki370"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq399"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw408"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906696"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104425"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168002"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00308-12"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/cb5006118"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/cb400100g"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01953-15"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2018.07.004"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2019.1568962"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.03.037"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30647"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006370107"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm076"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku316"},{"key":"ref48\/cit48","unstructured":"Wittekind, M., Weinheirner, S., Zhang, Y., and Goldfarb, V. Modified forms of hepatitis C NS3 protease for facilitating inhibitor screening and structural studies of protease-inhibitor complexes. U.S. Patent 6333186, Aug 8, 2002."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21786"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(97)76066-X"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909052925"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444994003112"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm216"},{"key":"ref56\/cit56","unstructured":"PyMOL: The PyMOL Molecular Graphics System\n                      ,\n                      Version 1.8; Schr\u00f6dinger, LLC."},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.6b01262"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02531-09"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1998.3014"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschembio.9b00675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T21:13:02Z","timestamp":1682111582000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.9b00675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,23]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,21]]}},"alternative-id":["10.1021\/acschembio.9b00675"],"URL":"https:\/\/doi.org\/10.1021\/acschembio.9b00675","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/692392","asserted-by":"object"}]},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,23]]}}}