{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:19:49Z","timestamp":1773472789173,"version":"3.50.1"},"reference-count":17,"publisher":"American Chemical Society (ACS)","issue":"10","funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["S10RR024664"],"award-info":[{"award-number":["S10RR024664"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["5U54HG005031"],"award-info":[{"award-number":["5U54HG005031"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["PO50-GM069663"],"award-info":[{"award-number":["PO50-GM069663"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Comb. Sci."],"published-print":{"date-parts":[[2015,10,12]]},"DOI":"10.1021\/acscombsci.5b00101","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T13:39:38Z","timestamp":1441201178000},"page":"641-652","source":"Crossref","is-referenced-by-count":27,"title":["High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors"],"prefix":"10.1021","volume":"17","author":[{"given":"Shanshan","family":"He","sequence":"first","affiliation":[{"name":"Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashi","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billy","family":"Lin","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ferrer","sequence":"additional","affiliation":[{"name":"NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongyi","family":"Hu","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Southall","sequence":"additional","affiliation":[{"name":"NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Hu","sequence":"additional","affiliation":[{"name":"NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Neuenswander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul-Hee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa A.","family":"Worlikar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Aub\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C.","family":"Larock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J.","family":"Schoenen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Marugan","sequence":"additional","affiliation":[{"name":"NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Jake","family":"Liang","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Frankowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2015,9,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.09.002"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26141"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3183"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1213651"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nature04080"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1403619"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02094-13"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/cc800120y"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1331765"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(97)01414-7"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/tx9601622"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-381290-2.00001-X"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/ja962466g"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010286"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00690-07"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"6705","DOI":"10.1128\/jvi.69.11.6705-6711.1995","volume":"69","author":"He J.","year":"1995","journal-title":"J. Virol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/S0090-9556(24)14938-0","volume":"27","author":"Obach R. S.","year":"1999","journal-title":"Drug Metab. Dispos."}],"container-title":["ACS Combinatorial Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acscombsci.5b00101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T10:53:25Z","timestamp":1748602405000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acscombsci.5b00101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,17]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10,12]]}},"alternative-id":["10.1021\/acscombsci.5b00101"],"URL":"https:\/\/doi.org\/10.1021\/acscombsci.5b00101","relation":{},"ISSN":["2156-8952","2156-8944"],"issn-type":[{"value":"2156-8952","type":"print"},{"value":"2156-8944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,17]]}}}