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The scope and limitations of this reaction were investigated by performing &amp;gt;70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design.<\/jats:p>","DOI":"10.1021\/acscombsci.7b00033","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T11:14:42Z","timestamp":1488194082000},"page":"343-350","source":"Crossref","is-referenced-by-count":27,"title":["Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis\nby Ugi Reaction"],"prefix":"10.1021","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0903-8174","authenticated-orcid":true,"given":"Pravin","family":"Patil","sequence":"first","affiliation":[{"name":"University of Groningen , , Antonius Deusinglaan 1 , ,","place":["Groningen, The Netherlands, 9713 AV"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kurpiewska","sequence":"additional","affiliation":[{"name":"Jagiellonian University , , Ingardena 3 , ,","place":["Krako\u0301w, Poland, 30-060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Kalinowska-T\u0142us\u0301cik","sequence":"additional","affiliation":[{"name":"Jagiellonian University , , Ingardena 3 , ,","place":["Krako\u0301w, Poland, 30-060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-8873","authenticated-orcid":true,"given":"Alexander","family":"Do\u0308mling","sequence":"additional","affiliation":[{"name":"University of Groningen , , Antonius Deusinglaan 1 , ,","place":["Groningen, The Netherlands, 9713 AV"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"2026090214332016600_cit1","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.1021\/cr200398y","article-title":"2,5-Diketopiperazines:\nSynthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products","volume":"112","author":"Borthwick","year":"2012","journal-title":"Chem. 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