{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:18:38Z","timestamp":1793071118434,"version":"4.5.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The use of DNA-encoded libraries has emerged as a powerful hit generation technology. Combining the power of combinatorial chemistry to enumerate large compound collections with the efficiency of affinity selection in pools, the methodology makes it possible to interrogate vast chemical space against biological targets of pharmaceutical relevance. Thus, the chemical transformations employed for the synthesis of encoded libraries play a crucial role in the identification of diverse and drug-like starting points. Currently established transformations have mostly been limited to water-compatible reactions to accommodate the growing oligonucleotide tag. Herein, we describe the development of a practical catch-and-release methodology utilizing a cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate the usefulness of our APTAC (amphiphilic polymer-facilitated transformations under anhydrous conditions) approach by performing several challenging transformations on DNA-conjugated small molecules in pure organic solvents: the addition of a carbanion equivalent to a DNA-conjugated ketone in tetrahydrofuran, the synthesis of saturated heterocycles using the tin (Sn) amine protocol (SnAP) in dichloromethane, and the dual-catalytic (Ir\/Ni) metallaphotoredox decarboxylative cross-coupling of carboxylic acids to DNA-conjugated aryl halides in DMSO. In addition, we demonstrate the feasibility of the latter in multititer-plate format.<\/jats:p>","DOI":"10.1021\/acscombsci.9b00164","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T17:45:00Z","timestamp":1581356700000},"page":"120-128","source":"Crossref","is-referenced-by-count":62,"title":["An Amphiphilic Polymer-Supported Strategy Enables\nChemical Transformations under Anhydrous Conditions for DNA-Encoded\nLibrary Synthesis"],"prefix":"10.1021","volume":"22","author":[{"given":"Yves","family":"Ruff","sequence":"first","affiliation":[{"name":"Novartis Pharma AG , , Novartis Campus , , ,","place":["Basel, Switzerland, CH-4002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Martinez","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG , , Novartis Campus , , ,","place":["Basel, Switzerland, CH-4002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Pelle\u0301","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG , , Novartis Campus , , ,","place":["Basel, Switzerland, CH-4002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Nimsgern","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG , , Novartis Campus , , ,","place":["Basel, Switzerland, CH-4002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Fille","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG , , Novartis Campus , , ,","place":["Basel, Switzerland, CH-4002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Ratnikov","sequence":"additional","affiliation":[{"name":"Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive , , ,","place":["San Diego, California, United States, 92121"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6673-3915","authenticated-orcid":true,"given":"Fre\u0301de\u0301ric","family":"Berst","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG , , Novartis Campus , , ,","place":["Basel, Switzerland, CH-4002"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"issue":"12","key":"2026090214340564400_cit1","doi-asserted-by":"publisher","first-page":"5381","DOI":"10.1073\/pnas.89.12.5381","article-title":"Encoded combinatorial chemistry","volume":"89","author":"Brenner","year":"1992","journal-title":"Proc. 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Drug Discovery"},{"issue":"11","key":"2026090214340564400_cit4","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1016\/j.drudis.2016.07.013","article-title":"DNA-encoded chemical\nlibraries: foundations and applications in lead\ndiscovery","volume":"21","author":"Zimmermann","year":"2016","journal-title":"Drug Discovery Today"},{"issue":"2","key":"2026090214340564400_cit5","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1021\/acschembio.5b00981","article-title":"Chemical Biology Probes from Advanced DNA-encoded Libraries","volume":"11","author":"Salamon","year":"2016","journal-title":"ACS Chem. 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Lett."},{"issue":"10","key":"2026090214340564400_cit43","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1021\/acscombsci.9b00113","article-title":"A Solution Phase\nPlatform to Characterize Chemical Reaction Compatibility with DNA-Encoded\nChemical Library Synthesis","volume":"21","author":"Ratnayake","year":"2019","journal-title":"ACS Comb. Sci."},{"issue":"7","key":"2026090214340564400_cit44","doi-asserted-by":"publisher","first-page":"5322","DOI":"10.1021\/cr300503r","article-title":"Visible Light Photoredox Catalysis\nwith Transition Metal Complexes: Applications in Organic Synthesis","volume":"113","author":"Prier","year":"2013","journal-title":"Chem. Rev."},{"key":"2026090214340564400_cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-017-0052","article-title":"The\nmerger of transition metal and photocatalysis","volume":"1","author":"Twilton","year":"2017","journal-title":"Nature Reviews Chemistry"},{"issue":"6195","key":"2026090214340564400_cit46","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1126\/science.1255525","article-title":"Merging photoredox with nickel catalysis: Coupling\nof \u03b1-carboxyl \u03b1-carboxyl sp3-carbons with aryl halides","volume":"345","author":"Zuo","year":"2014","journal-title":"Science"},{"issue":"7616","key":"2026090214340564400_cit47","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/nature19056","article-title":"Metallaphotoredox-catalysed\nsp3\u2013sp3 cross-coupling of carboxylic acids with alkyl halides","volume":"536","author":"Johnston","year":"2016","journal-title":"Nature"},{"issue":"3","key":"2026090214340564400_cit48","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1039\/c2md20347b","article-title":"Escape from\nFlatland 2: complexity and promiscuity","volume":"4","author":"Lovering","year":"2013","journal-title":"MedChemComm"},{"issue":"21","key":"2026090214340564400_cit49","doi-asserted-by":"publisher","first-page":"6752","DOI":"10.1021\/jm901241e","article-title":"Escape from\nFlatland: Increasing\nSaturation as an Approach to Improving Clinical Success","volume":"52","author":"Lovering","year":"2009","journal-title":"J. Med. Chem."},{"issue":"8","key":"2026090214340564400_cit50","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1021\/jacs.9b00669","article-title":"Open-Air Alkylation\nReactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis","volume":"141","author":"Phelan","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"2026090214340564400_cit51","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.3762\/bjoc.9.234","volume":"9","author":"Hu","year":"2013","journal-title":"Beilstein\nJ. Org. 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