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Evaluating cytotoxicity, genotoxicity, metabolic disturbance, oxidative stress, and quorum sensing via a new Toxic Index (TI) and Dynamic Time Warping (DTW) kinetic alignment, the panel unmasked complex cellular stress gradients. Although ICP-OES revealed localized mercury spikes (119 \u03bcg\/L), metals contributed minimally to overall toxicity. Instead, upstream freshwater exhibited severe, multi-pathway stress (Total Toxicity Index, TTI \u223c 2.48) statistically associated with trace bioactive organic fractions isolated via solid-phase extraction. In complex urban matrices, DTW effectively exposed non-monotonic toxicity masking. Conversely, the downstream estuarine TTI peak (3.06) was identified as an isolated, non-chemical osmotic shock response driven by extreme salinity (18,710 ppm total dissolved solids). This integrated framework demonstrates that relying on bulk chemical quantification inherently underestimates latent ecotoxicological hazards, proving the necessity of mechanistic biological diagnostics to accurately evaluate and protect complex aquatic ecosystems.<\/jats:p>","DOI":"10.1021\/acsestwater.6c00629","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:01:55Z","timestamp":1789549315000},"page":"6445-6459","source":"Crossref","is-referenced-by-count":0,"title":["Effect-Directed\nToxicity Assessment of the Surface\nWater of Chao Phraya River by Integrating a Panel of Bioluminescent\n                    <i>E. coli<\/i>\n                    with ICP-OES and HPLC-DAD"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0008-8052","authenticated-orcid":true,"given":"Calin","family":"Trif","sequence":"first","affiliation":[{"name":"Thammasat University , , ,","place":["Pathum Thani, Thailand, 12120"]},{"name":"Thammasat University , , ,","place":["Pathum Thani, Thailand, 12120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witthawat","family":"Piampowdee","sequence":"additional","affiliation":[{"name":"Thammasat University , , ,","place":["Pathum Thani, Thailand, 12120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiravoot","family":"Pechyen","sequence":"additional","affiliation":[{"name":"Thammasat University , , ,","place":["Pathum Thani, Thailand, 12120"]},{"name":"Thammasat University , , ,","place":["Pathum Thani, Thailand, 12120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9697-3805","authenticated-orcid":true,"given":"Robert S.","family":"Marks","sequence":"additional","affiliation":[{"name":"Ben-Gurion University of the Negev , , ,","place":["Beer-Sheva, Israel, 84105"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yardnapar","family":"Parcharoen","sequence":"additional","affiliation":[{"name":"Thammasat University , , ,","place":["Pathum Thani, Thailand, 12120"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"1","key":"2026100910095106900_cit1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/brv.12332","article-title":"A suite of essential biodiversity\nvariables for detecting critical biodiversity change","volume":"93","author":"Schmeller","year":"2018","journal-title":"Biol. 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